Southampton and Bristol City will fight for a place in the League Cup fourth round as they go head to head at St Mary's Stadium on Tuesday.
City sprung one of the major surprises of the previous round as they defeated Premier League opponents Crystal Palace 2-1 at Ashton Gate to set up another tie with top-flight opposition.
That win was in stark contrast to their league form this season, with Sean O'Driscoll's side seemingly unable to shake off the disappointment of last year's relegation from the Championship.
City, for whom semi-finals appearances in 1971 and 1989 remain their strongest League Cup showing, have struggled to arrest the slide so far this term and they currently occupy one of League One's relegation spots, with just four points from their opening eight games.
The cup competitions have proved a welcome distraction for O'Driscoll's side, who have beaten Gillingham and Palace in the League Cup, while they also beat local rivals Bristol Rivers 2-1 in the Football League Trophy.
The club's league form remains a concern though, and O'Driscoll has pleaded for patience from the fans during what is a period of transition.
"This is going to be a difficult season - I've said it time and time again," he said.
"We're not anywhere near where we should be because we are still starting on this journey."
Midfielder Stephen Pearson will not make the trip to Southampton, after it was announced he will miss the next six months with an ankle injury, but O'Driscoll revealed that Jordan Wynter and Neil Kilkenny are both back in training after recovering from knocks.
Southampton, defeated League Cup finalists in 1979, reached the third round with a 5-1 thumping of Barnsley last month.
They will enter the match fresh off a superb 1-0 Premier League win at Liverpool thanks to Dejan Lovren's second-half header.
Southampton have found goals tougher to score in the top-flight though, netting three in five encounters.
The two sides last met in the competition in October 2003, when goals from James Beattie, Brett Ormerod and Greame Le Saux helped them to a 3-0 win in the third round.
And a similar result looks likely given the respective form of the two sides heading into the encounter.
|26||J. Hooiveld||13' 83'|
|Coach: M. Pochettino|
for T. Lee 73'
for Guly 73'
for S. Davis 87'
|Kiessling calls for Leverkusen response|
|Matuidi: Cavani on par with Ibrahimovic|
|Yeboah set to join Borussia Monchengladbach|
|Rooney a ´chance´ to face West Ham|
|FIFA Club World Cup Preview: Bayern Munich v Raja Casablanca|
|Benzarti praises ´extremely talented´ Raja Casablanca|
|Ranieri unsure over Falcao return|
|Coupe de La Ligue Wrap: Cavani leads PSG to dramatic win|
|Copa del Rey Wrap: Real Madrid through as Sevilla crash out|
|Tottenham job appeals to Sherwood|
|Sherwood gutted after defeat|
|Hughes: United worthy winners|
|Moyes pleased to see United weather storm|
|Allardyce hails West Ham fight|
|Coppa Italia: Juventus 3 Avellino 0|
|Manchester clubs kept apart in League Cup semi draw|
|League Cup: Tottenham 1 West Ham 2|
|League Cup: Stoke City 0 Manchester United 2|
|FIFA Club World Cup: Raja Casablanca 3 Atletico Mineiro 1|
|Sheffield Wednesday, Wigan abandoned due to heavy rain|
|United face anxious Rooney wait over injury|
|Messi making good progress|
|Ramos ban overturned|
|Osvaldo charged by FA|
|In-demand Ince offered new Blackpool deal|
|Molde confirm Solskjaer approaches|
|Kramer keen to continue home record|
|Rodgers: Henderson has potential to get even better|
|Ruiz on Anderlecht´s radar|
|Swansea, Hull fined by FA over player behaviour|
|Leeds keen on re-signing Gradel|
|Leverkusen announce Ryu deal|
|Ribery named Bundesliga Player of the Year|
|Moyes: No Zaha interest|
|Barcelona, Real Madrid in European Commission investigation|
|Basel: No Tottenham approach for Yakin|
|Chelsea set for Guarin bid, agent claims|
|Lewandowski has Dortmund goal concerns|
|Pogba, Pirlo will not sign before Christmas, says Marotta|
|Guardiola convinced to join Bayern after ´meat´ and greet|
|Martinez: Everton seen as a ´perfect´ loan destination|
|Anderlecht ´perfect´ for Defour, says Van Holsbeeck|
|Watford appoint Sannino|
|Sakho feels ´lucky´ to play with Suarez|
|Lippi: Too many teams competing in Club World Cup|
|Moyes ´told Welbeck to learn from Rooney´|
|I would kill myself over match-fixing, says Gattuso|
|Hughes dismisses calls for Januzaj protection|
|Aguero ´could miss up to two months´|
|Guardiola lauds Ballon d´Or nominee Ribery|
|Liverpool open Suarez contract talks|
|Copa del Rey Wrap: Barcelona, Levante cruise through|
|A-League Preview: Derby date beckons for winless Heart|
|Pearson upbeat despite Leicester defeat|
|Poyet urges Sunderland to build on Chelsea win|
|Mourinho rues missed chances|
|Pellegrini proud of professional Manchester City|
|Bayern on another level, says Beckenbauer|
|League Cup: Sunderland 2 Chelsea 1 (aet)|
|League Cup: Leicester City 1 Manchester City 3|
|FIFA Club World Cup: Guangzhou Evergrande 0 Bayern Munich 3|
|Zenit and Olympiacos punished with partial stadium closures|
|Sherwood wants positive reaction|
|Ancelotti expected La Liga title fight|
|Moffat charged over betting allegations|
|Wilson appointed at Barnsley|
|Wilshere charged by FA|
|Gattuso determined to clear his name|
|Moyes slams sacking culture|
|Mackay refuses to resign despite owner criticism|
|Redknapp reluctant to take Taarabt back|
|Amat pleased with development|
|Hughes optimistic of League Cup progression|
|Perez: No bids for Di Maria|
|FIFPro demand transfer system overhaul|
|Edwards sacked by Perth Glory|
|Allardyce not fearing the sack|
|Howson commits to Norwich|
|Tevez resigned to Argentina snub|
|SFA uphold Butcher´s one-match ban|
|Zapata rules out United switch|
|European Ombudsman calls for action on Spanish tax complaint|
|Albrighton eyes new Villa deal|
|Bale to miss Copa del Rey clash with ´small injury´|
|Pardew will bide his time in January|
|Kreuzer confident of Hamburg improvement|
|Van der Sar: Moyes can turn United around|
|Maradona backs Ronaldo for Ballon d´Or|
|Tottenham warned off Klinsmann|
|Costa Rica Primera Division: Alajuelense 0 Herediano 0|
|Lyon wary of Chornomorets Odesa|
|Guardiola talks up Lippi, Evergrande|
|Chile Primera Division Wrap: Chile, Deportes Iquique reach final|
|Garcia laments defensive mistakes|
|La Liga: Real Valladolid 3 Celta Vigo 0|