Barcelona will be looking to retain their 100 per cent start in Gerardo Martino's first season in charge when they head to Rayo Vallecano.
The champions travel to Madrid on Saturday with 12 points from their four La Liga matches this season - plus a 4-0 win over Ajax in their UEFA Champions League opener - and will face a side that has conceded 12 goals in their previous three games.
Barcelona have scored a dozen goals in their last two visits to the Estadio de Vallecas Teresa Rivero - winning 5-0 last term and 7-0 in 2011-12 - and have not lost to Paco Jemez's men since December 2002.
Real Madrid go into their fixture at home to Getafe on Sunday two points adrift of their rivals after being held to an entertaining 2-2 draw at Villarreal last time out.
However, they will be high on confidence after following that result up with a resounding 6-1 win at Galatasaray in the Champions League on Tuesday.
Cristiano Ronaldo scored four goals over the course of those two matches, while Gareth Bale got his Real career off to a flying start by scoring on his debut at El Madrigal.
Getafe may have beaten their more illustrious city neighbours at home in August last year, but they have conceded four times in each of their last three visits to the Bernabeu.
The only other side who can match Barcelona's perfect start thus far is Diego Simeone's Atletico Madrid.
Wins against Sevilla, Rayo, Real Sociedad and Almeria have seen them take maximum points from their four games, while they also got their European campaign off to a flyer by beating Zenit St Petersburg 3-1 in the Champions League on Wednesday.
Striker Diego Costa has netted four goals in his last four outings, and Atletico will head to Real Valladolid on Saturday confident of another victory having won the last four meetings between the sides.
Elsewhere, newly promoted Villarreal travel to Celta Vigo in joint second place with Real Madrid with 10 points from their opening fixtures, while Valencia host Sevilla in a match where both sides have points to prove.
Valencia have managed only one win thus far and were comfortably beaten by Sevilla's city rivals Real Betis last time out, while their visitors are still looking for a first victory of the season.
Three other sides are also still searching for a victory to kick start their campaigns. Osasuna host fellow strugglers Elche, while Almeria welcome Levante to Estadio de los Juegos Mediterraneos.
Real Sociedad will be back in domestic action after a Champions League reality check in which they were defeated 2-0 at home by Shakhtar Donetsk. Their latest visitors will be Malaga, who thrashed Rayo 5-0 last time out.
Meanwhile, Andalucian duo Betis and Granada face each other at the Estadio Benito Villamarin, and Monday's game sees Athletic Bilbao travel to Espanyol.
|10||Roberto Trashorras||23' 36'|
|Coach: Paco Jémez|
for Tito 46'
for Alberto Perea 48'
for Jonathan Viera 58'
|Jovetic ready to lead City line - Pellegrini|
|Lewandowski impresses Ribery, Alaba|
|Colombian Primera A Review: Three clubs remain perfect, Atletico Nacional get off the mark|
|Rodgers: ´We can score goals´ without Suarez|
|Chilean Primera Division Review: Canales brace powers Universidad Chile|
|Atletico Madrid need penalties to edge past Earthquakes|
|Liga MX Review: Monterrey, America stay perfect|
|Paraguayan Primera Division Review: Capiata set pace|
|Brazilian Serie A Review: Cruzeiro win again, Kaka scores|
|Sterling goal sees Liverpool past Olympiacos|
|Peruvian Primera Division Review: Los Caimanes notch maiden win, Inti Gas claim top spot|
|CAF Champions League Review: Zamalek held, Vita Club leave it late|
|Jovetic at the double as Manchester City thrash Milan|
|Monk thrilled by Sigurdsson contribution|
|Lovren signs for Liverpool|
|Mourinho pleased with Olimpija test|
|Vertonghen eager to remain at Spurs|
|Sigurdsson marks Swansea return with a brace|
|Lewandowski, Rode help Bayern retain Telekom Cup|
|Immobile scores and suffers injury in Dortmund win|
|Costa scores on Chelsea debut|
|CAF Confederation Cup Review: Leopards de Dolisie 1 Real Bamako 2|
|Thai Premier League Review: Buriram pull clear, Police edge away from danger|
|Falcao nears Monaco return|
|CSL Review: Harbin Yiteng produce another upset, Evergrande stretch lead|
|Britton and Emnes to miss season-opener|
|Taylor-Fletcher strike sinks Everton|
|J.League Review: Chasing pack close on Urawa Reds, Tokushima Vortis secure rare win|
|Ancelotti expects fresh Bale to be even better|
|Simeone keen on Griezmann|
|Mazzarri refuses to set Inter targets|
|Lazio director targeted by fans|
|Dyche rules out Deeney move|
|Rummenigge: Bayern will never sack Guardiola|
|BREAKING NEWS: Arsenal to bring in Ospina|
|Pochettino quiet on Schneiderlin link|
|Vidic settling into Inter life|
|Van Gaal hints at Zaha United future|
|Di Maria will report for training - Ancelotti|
|Wilshere vows to answer critics|
|Rodgers expecting titles|
|Deila demands Celtic cutting edge|
|Rodgers: We won´t rush Lallana|
|Wenger: We have to be better against top-level teams|
|FIGC presidential candidate uses racist slur|
|MLS Review: Columbus claim second straight win, Toronto falter|
|Villa battle past Dynamo in Houston|
|United more efficient, says Garcia|
|Pedestrian Tottenham edge past Chicago Fire|
|Van Gaal bemoans display|
|CS Sfaxien 1 ES Tunis 0: Troussier era opens with a win|
|Icardi stars from the spot as Inter overcome Real Madrid|
|Arsenal upstaged by Red Bulls|
|Pre-Season Friendly Review: Rooney stars for United, Bayern reach Telekom final|
|In-form Rooney inspires Manchester United win|
|CAF Confederation Cup Review: Cotonsport on verge of progress|
|Ribery helps Bayern to penalty victory on return|
|Balzaretti suffers another injury blow|
|Puel confirms Ospina departure|
|Beckham backs Rodriguez to be Real hit|
|Bojan fails to inspire Stoke|
|Long on target as Hull held by Barnsley|
|Cardiff issue Medel warning|
|Ferreyra sorry for late Shakhtar return|
|Payet rules out Swansea move|
|Gilchrist nets winner as Burnley edge Accrington|
|Cazorla optimistic for new season|
|Celtic suffer St Pauli defeat|
|QPR lose on Ferdinand debut|
|Mashaba handed Bafana Bafana role|
|Van Aanholt eager to prove himself|
|Areola completes Bastia loan switch|
|Ospina imminent, but Szczesny gets Wenger´s backing|
|Reus happy with progress|
|Alleged spot-fixers released|
|Giuly: Mathieu can be the next Abidal|
|Allardyce hoping to keep hold of Morrison|
|Monk hails quality of Swansea additions|
|Van Gaal orders United players to speak English|
|Allardyce: We must improve|
|Campbell thrilled by Palace switch|
|Bojan drawn by Stoke style|
|Palace were wasteful, says Pulis|
|Van Gaal suits me - Cleverley|
|Newcastle stay perfect in NZ|
|Van Gaal prepared to wait for Strootman|
|West Brom overcome Sacramento|
|Colorado Rapids 3 Chivas USA 0: Hosts rise to third in the West|
|Gameiro brace adds to West Ham woes|
|Villas-Boas: Rodriguez best suited to no.10 role|
|Cazorla: I´m happy at Arsenal|
|Reina respects Liverpool contract|
|Lampard could move to Melbourne on loan|
|Galliani: Balotelli ´99.9 per cent´ staying|
|Own goal helps Palace win in Philadelphia|
|Mourinho: Shaw deal would have ´killed´ Chelsea|
|Al Ahli Benghazi 0 ES Setif 2: Visitors on verge of semi-final spot|
|Julio Cesar returns to QPR|
|Rooney wants to lead United|