A Wayne Rooney brace saw Manchester United romp to a 4-2 win over Bayer Leverkusen in David Moyes' UEFA Champions League group stage debut.
The England international became only the fourth man in United's history to score 200 goals, after notching either side of half-time.
Rooney opened the scoring in the first half with a guided volley, but Simon Rolfes equalised against the run of play shortly after the break.
Robin van Persie put United back ahead shortly afterwards, before Rooney pounced on a lapse in the Leverkusen defence to make it 3-1 and Antonio Valencia scored a counter-attacking goal.
Omer Toprak pulled one back for Leverkusen with three minutes left, but it was scant consolation.
Marouane Fellaini made his first start for United since his deadline-day move from Everton, while Shinji Kagawa was included in the starting XI for the first time this season.
Leverkusen boss Sami Hyypia brought in Giulio Donati, Toprak and Emre Can to bolster the side that defeated Wolfsburg 3-1 on Saturday.
United controlled the tempo in the early exchanges and Chris Smalling almost broke the deadlock in the 22nd minute when he looped a header narrowly over the crossbar.
But just two minutes later the home fans were celebrating a goal their team's play deserved.
Patrice Evra gathered the ball on the left and played a pin-point cross to Rooney, who hit a first-time volley that hit the floor and bounced into the roof of the net – although television replays suggested that Valencia may have blocked goalkeeper Bernd Leno in an offside position.
Moyes' side nearly grabbed a second before half-time when Rooney's 25-yard free-kick from the left bounced narrowly wide of Leno's near post before Rooney pounced on a Toprak slip just after the restart but rounded the goalkeeper only to fire wide.
United were immediately punished when Leverkusen made it 1-1 in the 54th minute.
Heung-Min Son held the ball up well in the box before laying back to Rolfes, who hit a first-time bending effort from 20 yards that deflected off Michael Carrick beyond David De Gea.
They were not level for long and Van Persie restored United's lead in the 59th minute as Valencia surged down the right and centred for the Netherland's international to stretch and guide his volley into the back of the net.
And with 20 minutes remaining the result was put beyond doubt when De Gea's long punt down field caused confusion in the Leverkusen defence, and Rooney collected on the left before calmly slotting home at the near post.
Moyes' night got even better when with just 10 minutes left United broke from their own half before Rooney played an accurate ball into the path of Valencia who rifled home.
With three minutes left Toprak grabbed a consolation when he tapped home a rebounded effort after Stefan Reinartz headed against the crossbar from a corner.
|20||R. van Persie||39' 59'|
|10||W. Rooney||22' 70'|
|Coach: D. Moyes|
for S. Kagawa 71'
for M. Fellaini 80'
for W. Rooney 84'
|Argentina forward Lavezzi suffers hamstring scare|
|Koeman talks ´very positive´, say Southampton|
|Rami replaces injured Varane in France´s Euro 2016 squad|
|Matthaus applauds Gotze for rejecting ´easy solution´ of Liverpool|
|Suarez silenced his doubters - De Boer|
|AFC Champions League Review: Jeonbuk, Shanghai SIPG progress|
|Klopp can take Liverpool right to the top, says McAllister|
|Lindelof happy at Benfica amid Real Madrid, Barcelona links|
|Zidane is perfect on and off the pitch - Lippi|
|Bale: Zidane has brought the best out of Real Madrid|
|Favre takes over as Puel and Nice part ways|
|Liverpool complete Karius deal|
|Van Gaal was treated poorly by United, but Mourinho will be a success - De Boer|
|Dani Alves: I have won more titles than Pele|
|I know who I´m taking - Conte sure on Euro 2016 selection|
|Xavi backs Guardiola to ´change the face of English football´|
|Lucescu appointed Zenit boss|
|Manchester United and Liverpool hit with €40,000 fines|
|Weinzierl: I have nothing to lose at Schalke|
|Rangers complete Barton signing|
|Italy better placed as underdogs ahead of Euro´s - Motta|
|Cantona: I love Mourinho, but he is not Manchester United|
|Ben Arfa wants Lyon move - Aulas|
|David Silva praises Iniesta´s Copa del Rey heroics|
|´It was a little scare´ - Ronaldo plays down injury fears|
|Eder the real deal for Lille|
|Van Gaal treated unfairly during Manchester United spell - Daley Blind|
|Ginola doing ´very well´ after heart surgery|
|Depay rules out Manchester United exit following Van Gaal departure|
|Hojbjerg confirms desire to leave Bayern|
|Ronaldo leaves Madrid training early after knock|
|Abbiati unimpressed with Milan players´ attitude|
|Pepe calls on Madrid to continue making history|
|Ayestaran signs two-year deal with Valencia|
|Montolivo, Antonelli sign new AC Milan contracts|
|Ronaldo ready for UCL final after being rested from practice match|
|Hummels, Sanches deals will not stop Bayern spending - Rummenigge|
|Oblak´s penalty heroics, Griezmann´s Barcelona brace - Atletico Madrid´s route to the Champions Leag|
|Salvio all but confirms Gaitan will join Atletico Madrid|
|Motta warns PSG over Ronaldo, Neymar interest|
|Europa League Mourinho´s best hope for United trophy - Sheringham|
|Injustice if Iniesta never wins a Ballon d´Or - Del Bosque|
|Van Gaal didn´t deserve United sacking - Blind|
|I´ll be happy if we make Euro 2016 semi-finals - Del Bosque|
|Koke: Why would I want to leave Atletico?|
|Fofana could retire aged 25 - Lyon president|
|Sandro set to leave Barcelona|
|Silva plays down injury worries ahead of Euro 2016|
|United would be brave to appoint Mourinho, says Schmeichel|
|Neymar adamant he is happy at Barcelona|
|Wilshere: Arsenal play me out of position|
|Ryan backs former coach Neville|
|Keane talks up Galaxy move for Ronaldo|
|´Free agent´ Diarra wants Mourinho reunion|
|Eintracht Frankfurt beat Nuremberg to secure Bundesliga status|
|Manchester United to turn to Mourinho, the man who most resembles Ferguson|
|Manchester United kids are Van Gaal´s legacy - Ferdinand|
|´Sex-masochism´, ´fat man´ and ´Mr Mike Smalling´ - Van Gaal´s best quotes as Manchester United mana|
|I have fulfilled a long-held ambition - ´Very disappointed´ Van Gaal´s statement in full|
|Van Gaal should call time on career after Manchester United sacking|
|Better than Busby? - The stats behind Van Gaal´s United exit|
|Van Gaal sacked by Manchester United|
|Suarez expected to miss Copa America group stage|
|Herrera wants more trophies with Manchester United|
|FIFA sacks deputy secretary general Kattner|
|Asensio wants to fight for his chance at Real Madrid|
|SFA to investigate Rangers-Hibernian disorder|
|Van der Wiel takes aim at Blanc after PSG exit|
|Halilovic: Missing Euro 2016 would not be a tragedy|
|Van Gaal leaves United training ground as Mourinho speculation goes on|
|Zanetti rules out Inter move for Simeone|
|Rodgers adamant Celtic is not a step down|
|Sanches chose Bayern Munich over Manchester United|
|Rosicky was the perfect player for Arsenal - Wenger|
|Tonelli becomes Napoli´s first close-season signing|
|Thigh injury rules Steffen out of Euro 2016|
|Gotze is a perfect fit for Liverpool - Hitzfeld|
|Hummels completes Bayern move after passing medical|
|Guardiola era has been sensational - Neuer|
|Bayern will never sign a Messi or Ronaldo - Hitzfeld|
|Wilkins backs Mourinho appointment|
|Suarez´s Copa America hopes alive despite hamstring injury|
|Delneri exits Verona following relegation|
|Ireland´s Wilson ruled out of Euro 2016|
|Gotze looking forward to new season with Bayern|
|Pirlo, Giovinco out of Italy Euro 2016 squad|
|Coleman signs new Wales contract|
|Gotze talk intensifies as Bayern Munich forward leaves agent|
|Rami called up by France following Varane injury|
|United States v Ecuador: Klinsmann pins hopes on Yedlin as Copa preparations continue|
|Gabriel, Lucas Lima unsure on Santos futures|
|AC Milan to terminate Mihajlovic deal in June|
|Emery confirms Banega will leave Sevilla|
|Neville still unsure over Valencia future|
|Van Gaal arrives at United training ground amid Mourinho talk|
|Messi: We suffered but we won together|
|Evra confirms two-year Juventus deal|
|Son unfazed by Tottenham exit rumours|
|Argentine footballer dead after being struck in head|
|Arnautovic refuses to commit to Stoke|
|Sirigu: PSG wanted me out|
|MLS Review: Galaxy held by Earthquakes, Timbers end skid|
|Alba: Messi deserves credit for my goal|
|Pique: Barca deserved Copa del Rey title|
|Smalling admits relief after Lingard winner|
|Suarez, Barca unsure on extent of injury|
|Luis Enrique revels in Barca´s spectacular end to season|
|Emery proud in Copa del Rey defeat|
|Rooney hopes FA Cup lifts United - with or without Van Gaal|
|Iniesta: Copa del Rey win caps magnificent season|
|Barcelona 2 Sevilla 0 (AET): Alba and Neymar decide heated Copa del Rey final|