Chelsea's bid to win a third major European trophy in successive seasons begins when they host Basel in the UEFA Champions League.
The Premier League side won the UEFA Europa League last season, while they lifted the Champions League in the 2011-12 campaign, and they will be determined to claim the main prize again.
Wednesday's Group E clash at Stamford Bridge will be vital for the London club, with returning manager Jose Mourinho sure to demand a fast start from his men.
Chelsea and Basel are well acquainted, having met in the semi-finals of the Europa League last term, with Chelsea winning 5-2 on aggregate.
That success came under interim manager Rafael Benitez, though, with Mourinho in charge now as he looks to win the title for the third time.
Mourinho has won the Champions League at both Porto and Inter, but is yet to win it at Chelsea, coming closest in 2004-05 and 2006-07, when they reached the semi-finals.
Chelsea have not made an ideal start to the season, winning just two of their first four Premier League matches, while they lost to Bayern Munich in the Super Cup final on penalties last month.
As a result, they lie sixth in the Premier League table, with Saturday's 1-0 defeat at Everton fresh in the memory.
Cameroon international Samuel Eto'o made his debut in that fixture, but the 32-year-old striker was guilty of missing several chances.
Mourinho will expect more from the former Inter player, and Spaniard Fernando Torres may start as a result of his sub-standard performance.
Chelsea's array of young stars could all play big roles in the Champions League this season, with Oscar, Eden Hazard and Andre Schurrle all impressing in the early stages of the campaign.
Basel have their own stars to boast and among those is veteran forward Marco Streller, who has already racked up four goals in just five games in the Swiss Super League.
Their league form has been good, losing just one of their seven matches this season, and they sit third on the table as a result.
The Swiss side have form for giant-killing – they essentially knocked Manchester United out of the group stages in the 2011-12 Champions League by beating them on the last matchday of the group stages – and Murat Yakin's side have had to work hard for their spot in this year's competition.
They beat Maccabi Tel Aviv 4-3 on aggregate before toppling Ludogorets 6-2 in the play-off round.
|16||M. van Ginkel||42'|
|Coach: José Mourinho|
for Willian 67'
for F. Lampard 76'
for M. van Ginkel 76'
|Levante 2 Eibar 1: Comeback pulls hosts out of bottom three|
|Stuttgart 0 Hertha Berlin 0: Strugglers share the spoils|
|Toulouse 1 Marseille 6: Six of the best for Bielsa´s men|
|Fulham 1 Bournemouth 5: Howe´s men reclaim top spot in style|
|Willem II 2 Twente 2: Visitors come from behind to draw|
|Hanson expects fired-up Reading in quarter-final|
|Five Kano Pillars players wounded by gunmen|
|Kane and Austin could play together for England - Pochettino|
|Giggs refutes claims of Van Gaal spat|
|Barcelona v Rayo Vallecano: Jemez piles pressure on hosts|
|Gomez sidelined for two weeks|
|Evans to discover fate on Saturday after denying FA charge|
|Lens fixture will be good for Ibra, says Blanc|
|Knee surgery leaves Kessler´s World Cup hopes in jeopardy|
|Souleymane S rejects Chelsea offer to visit Stamford Bridge|
|Atletico Madrid v Valencia: In-form visitors out to overtake champions|
|Guardiola wants further improvement in attack|
|Basile: Messi does not need World Cup win|
|Liverpool v Blackburn Rovers: Rodgers calls for calm amid Henderson hype|
|Rodgers: Scrap Wembley semi-finals|
|Inzaghi rubbishes Tassotti talk|
|Adebayor not training with youth team, says Pochettino|
|Ancelotti plays down Danilo rumours|
|Wenger hits back at Scholes´ Ozil criticism|
|Aulas: Lacazette departure simply impossible|
|Qatar have sympathy for Euro clubs over World Cup switch|
|Blatter calls for more women on FIFA ExCo|
|Napoli v Inter: Benitez hails team spirit|
|Walters: Spit at me and you´ll eat through a straw|
|Pulis unperturbed by Sherwood comments|
|Abdennour extends Monaco contract|
|Parma reach agreement with stewards ahead of Atalanta game|
|Forecast good for Bradford´s Liddle|
|´Ibrahimovic only interested in winning´ - Raiola brushes off Cavani rumours|
|Rodgers helping Balotelli grow - Raiola|
|Newcastle Jets 0 Sydney 1: Janko´s red-hot run goes on|
|Ramsey not out to prove a point against Tottenham|
|Inter must win Europa League - Felipe|
|Gabriel sidelined by hamstring injury|
|I was overwhelmed by price tag - Ideye|
|Kaka excited about MLS debut|
|Ramsey appointment ´important´ for black issues in football - Rose|
|´Unbelievable´ Henderson at another level - Lallana|
|Copa Libertadores Review: Universidad Chile open account, Juan Aurich win|
|Herediano 2 Olimpia 0 (agg 3-1): Hosts through to semis|
|Kane no guarantee for England squad - Hodgson|
|Hart: Kompany will come back better than ever|
|Salah ´on fire´ - Montella|
|Fiorentina deserved to win - Allegri|
|Dunga: Neymar likes a challenge|
|Central Coast Mariners sack Moss|
|Tottenham heading to Sydney in May|
|Gomis collapse ´very difficult´ on Muamba|
|Sporting KC confirm interest in Van der Vaart|
|Coupe de France Review: Guingamp leave it late, Auxerre win on penalties|
|Juventus 1 Fiorentina 2: Salah double hands visitors advantage|
|New Cardiff badge to ditch Welsh dragon for ´oriental dragon´|
|Reid contract a ´real statement´ from West Ham, says Nelsen|
|BREAKING NEWS: Cisse accepts FA charge over spitting|
|Van Gaal fumes at suggestion of poor relationship with Giggs|
|Evans and Cisse charged over spitting|
|Cellino ban extended after settlement with Football League|
|Podolski could return to Arsenal, says agent|
|Van Gaal continues to stand by Evans|
|Sherwood wants blood and thunder FA Cup tie|
|QPR v Tottenham: Sandro targets early goals|
|Bradford City v Reading: Parkinson calls for best performance of the season|
|Aston Villa v West Brom: Sherwood expects repeat performance|
|Cisse apologises for spitting incident|
|Parkinson relishing Reading reunion|
|Suarez set for Anfield return|
|Toulouse deny Casanova replacement rumours|
|Reus remains a doubt for Hamburg clash|
|Evans denies spitting at Cisse|
|Robinho recalled to Brazil squad|
|Athletic Bilbao v Real Madrid: Ancelotti wants reaction|
|Milan v Verona: Hosts seek response|
|Hamburg v Borussia Dortmund: Resurgent visitors face bogey team|
|Lacazette: Lyon may sell for right price|
|Hannover v Bayern Munich: Champions prepared for battle|
|Paris Saint-Germain v Lens: David Luiz calls for focus|
|Cisse appointed Senegal coach|
|Bundesliga Preview: Immobile out to impress as Dortmund target top half|
|Ligue 1 Preview: Lyon aim to bounce back, PSG ready to pounce|
|La Liga Preview: Simeone looks to Torres, Real seek response|
|League Two Preview: Ainsworth keen to take pressure off, Burton seek return to winning ways|
|Busquets to miss Rayo clash|
|Championship Preview: Watford out for three wins in a week|
|League One Preview: Freeman issues rallying call to leaders|
|Gutierrez return lifted St James´ Park - Carver|
|Balotelli: ´Someone doesn´t like me´|
|Poyet charged by FA after Bruce spat|
|Sanchez resilience delights Wenger|
|Blanc brushes off PSG treble talk|
|Toure, Bony struggling with AFCON fatigue, claims Pellegrini|
|Gomis offers assurances over health|
|Emre can become world-class - Rodgers|
|Reid signs new West Ham deal|
|CONCACAF Champions League Review: America, Alajuelense advance|
|Magath open to Rangers role|
|Copa Libertadores Review: Corinthians preserve perfect record|
|MLS and players union reach agreement|
|Wenger hails Giroud´s mental strength|
|We didn´t give Espanyol a chance - Valverde|
|Benteke eyeing FA Cup glory|
|Serie A Preview: Inzaghi under pressure, Roma eye win|
|Sturridge: ´I am ready to play every game´|
|Luis Enrique coy on Busquets injury|
|Dyche realistic after Anfield loss|
|Matuidi sets sights on PSG quadruple|
|Championship Review: Wigan boost survival hopes, Blackpool´s misery continues|
|DFB-Pokal Review: Bayern through, Bremen upset|
|Hughes: Stoke evolution is ahead of schedule|
|Allardyce: Big calls went against West Ham|
|Van Gaal defends Evans amid spitting furore|
|Pearson calls for video technology after City snubs|
|Rodgers hails Henderson impact|
|Pochettino proud of Tottenham response|
|Kluivert appointed Curacao coach|
|´Devastated´ Carver slams referee for penalty gaffe|
|Hero Hazard thrills Mourinho|
|Benitez praises Napoli ´intensity´|
|Mourinho laughs off bizarre Matic injury|
|Gutierrez grateful for reception after beating cancer|
|Pellegrini explains Kompany omission|
|Guardiola underlines respect for beaten Braunschweig|
|Second-half display pleases Wenger as Arsenal maintain top-three place|
|Martinez wants united front at struggling Everton|