Atletico Madrid will seek a measure of revenge versus Zenit St Petersburg after being knocked out of Europe by a Russian side last season.
The Spanish club were beaten 2-1 on aggregate by Rubin Kazan in the last 32 of the UEFA Europa League last term and they kick off their Champions League campaign against Kazan's compatriots on Wednesday.
Diego Simeone's men secured their spot in the Champions League after finishing third in La Liga last term and they have started this season in fine form, with a 100 per cent record from four games.
They meet a Zenit side who have also enjoyed an excellent start to their domestic season, with Saturday's 2-0 victory over Terek Grozny lifting them to second in the Russian Premier League.
Despite losing Radamel Falcao to big-spending Monaco in the summer, Atletico still have a host of attacking talents to call upon.
Chief among them is former Barcelona attacker David Villa, who boasts a wealth of experience in European competition that could prove vital.
Another threat to Zenit will be Brazilian striker Diego Costa, who has enjoyed a fine start to the season.
The 24-year old admitted that he nearly joined English side Liverpool during the summer, but decided to stay loyal to Atletico and has been in great form ever since, finding the net four times in as many league outings.
Visitors Zenit did not travel well during last season's competition, losing four of their five away matches, but they also have a number of attacking options at their disposal.
Danny is among their key assets, with the Portuguese striker having scored six times in their last eight games. Coach Luciano Spalletti will also be hoping that Brazilian forward Hulk recovers from the hip injury that kept him out of action at the weekend.
Spalletti has been tipped as a possible replacement for Cesare Prandelli as Italy coach after the FIFA World Cup, but he insisted that he was enjoying the challenge in Russia.
"In St Petersburg I feel respected by an entire city, both as a sportsman and as a man," he said. "They helped me to work in the best possible circumstances, even during difficult moments, as the city, the fans and the club supported me.
"This is fundamental for me. I might be wrong, but I do everything with sentiment."
Zenit have not won in Spain in five previous attempts.
|Coach: D. Simeone|
for Adrián 79'
for A. Turan 86'
for Koke 89'
|Republic of Ireland 1-1 Netherlands: Boys in Green pegged back after Long goal|
|Hazard hints at Chelsea stay|
|Reinartz retires at 27 due to injuries|
|Bellerin not interested in rumours of Barcelona move|
|Zidane happy to fulfil Ancelotti´s prophecy|
|Ronaldo is 100 per cent fit for Champions League final - Zidane|
|Rummenigge: Bayern ready to welcome Hoeness back|
|Bordeaux name Gourvennec as new coach|
|Portugal v Norway: Quaresma challenges hosts to prove Euro 2016 ambition|
|Espanyol announce Galca exit|
|Spain v Bosnia-Herzegovina: Uncapped duo aim to impress|
|Middlesbrough confirm Fischer deal|
|Pearson targeting promotion after Derby appointment|
|England 2-1 Australia: Rashford and Rooney see off Socceroos|
|FIFA hits Croatia with stadium ban as part of widespread homophobia sanctions|
|Northern Ireland 3-0 Belarus: O'Neill's men cruise to victory|
|Italy v Scotland: Chiellini spots chance to prepare for Ireland challenge|
|Sane brushes off talk of Schalke exit|
|Yorke: Giggs should be Mourinho successor|
|Defence can lead Italy to Euro success - Chiellini|
|Scolari swoons over ´spectacular´ Ronaldo|
|Neuer to miss Germany friendly|
|Gabi looking forward, not back|
|Gerhardt agrees Wolfsburg switch|
|Champions League final is the game of my life - Torres|
|Simeone: Casemiro the key for Real|
|Mourinho urges United to ´forget the past three years´|
|Malaga appoint Ramos|
|Berlusconi ready to relinquish power at AC Milan|
|Busquets agrees new five-year Barcelona contract|
|Euro 2016 not under threat from strike action - Braillard|
|Real Madrid v Atletico Madrid: San Siro the stage for Champions League final re-run|
|Vela staying with Sociedad - agent|
|A poke in the eye & ´the f****** master´: Five of the best Mourinho v Guardiola battles|
|Red Devils enter Faustian pact as Manchester United hire Mourinho|
|Star striker top of Mourinho´s United shopping list|
|An attacking mastermind even more fearsome than Ferguson - Jose Mourinho in numbers|
|Manchester United appoint Mourinho as manager|
|Italy not among Euro 2016 favourites - Ancelotti|
|Win or lose in Milan, it is time for Perez to back Zidane|
|Ronaldo wants Morata back at Madrid|
|England v Australia preview: All eyes on Rashford debut|
|Weigl, Kimmich grateful to Tuchel and Guardiola|
|Benitez: I´m ready for Championship challenge|
|Colombia v Haiti: Bacca ready for responsibility|
|Karembeu hails Zidane ahead of Champions League final|
|Panama v Brazil: Lucas Lima ready to prove himself|
|Kaka replaces Douglas Costa in Brazil´s Copa America squad|
|Mascherano opens up on Juventus rumours|
|Allen unclear over Liverpool future|
|Hodgson praises scrapped cup replays|
|Deschamps to take legal action against Cantona|
|Kuyt signs new Feyenoord deal|
|Messi set for court appearance on June 2|
|Juninho tips Atletico for Champions League glory|
|Galatasaray 1 Fenerbahce 0: Podolski header settles Turkish Cup final|
|Skrtel set for Liverpool exit|
|Rashford set for England debut|
|Xavi: It is Atletico Madrid´s time to win the Champions League|
|Manchester United will be hard to beat with Mourinho - Courtois|
|Signing ´animal´ Ibrahimovic a no-brainer for Man Utd, says Henry|
|FA Cup quarter-final replays scrapped|
|Cantona suggests Deschamps dropped Ben Arfa and Benzema over race|
|Depay ´p***** off´ at lack of football|
|Ferdinand welcomes Mourinho to Manchester United|
|Delph placed on England standby list|
|Wales talisman Bale shrugs off Euro pressure|
|Ronaldo open to working under Mourinho again|
|Ronaldo values Champions League over Barcelona´s double|
|Switzerland v Belgium: Shaqiri eyes Euro glory|
|Willian: Manchester United stronger with Mourinho|
|Liverpool and Dortmund in for Guerreiro|
|Real Madrid will attack Atletico again, says Ancelotti|
|Ramirez set for Southampton exit|
|Bale calls for cool Madrid heads|
|´Mourinho can take United back to the top´ - Ibrahimovic hints at Old Trafford switch|
|Hull City v Sheffield Wednesday: Promotion windfall the prize on offer|
|Lahm eyes Champions League glory with Ancelotti|
|Juventus chief hints at Dani Alves deal|
|Gotze warned he will not be first choice under Ancelotti|
|Mexico v Paraguay Preview: Marquez ready to make the most of 'great opportunity'|
|Courtois: If nothing strange happens, I will continue at Chelsea|
|Vermaelen ´disappointed´ by Barca struggles|
|Higuain and Lamela dream of lifting the Copa America|
|Reborn Torres returns to Milan to complete Atletico´s greatest tale|
|Lukaku offers Everton ultimatum: I want to win trophies!|
|United States v Bolivia: Copa America hosts to fine-tune preparations|
|Zidane has united Real Madrid again - Ramos|
|Mexico v Paraguay: Marquez ready to make the most of ´great opportunity´|
|Republic of Ireland v Netherlands Preview: O'Neill wants confident display|
|Coyle leaves Houston Dynamo|
|McLaren could end Mercedes dominance - Alonso|
|Orlando City 2 Philadelphia Union 2: Tribbett rescues point in controversial contest|
|United States 1 Ecuador 0: Last-gasp Nagbe goal lifts hosts in Copa America warm-up|
|Djourou compares Xhaka to Pirlo|
|Gallas ´very proud´ of former boss Ranieri´s title glory|
|Copa America to use goal-line technology|
|Smith likens Postecoglou to Klopp|
|Hart backs Sterling to shine at Euro 2016|
|Giovinco happy in MLS despite Euro 2016 snub|
|Balotelli set for Liverpool return, confirms Berlusconi|
|Atletico must win Champions League - Cerezo|
|Arbeloa: Mourinho didn´t get enough recognition at Madrid|
|Mijatovic: Bale can save Madrid´s season in Champions League final|