Atletico Madrid will seek a measure of revenge versus Zenit St Petersburg after being knocked out of Europe by a Russian side last season.
The Spanish club were beaten 2-1 on aggregate by Rubin Kazan in the last 32 of the UEFA Europa League last term and they kick off their Champions League campaign against Kazan's compatriots on Wednesday.
Diego Simeone's men secured their spot in the Champions League after finishing third in La Liga last term and they have started this season in fine form, with a 100 per cent record from four games.
They meet a Zenit side who have also enjoyed an excellent start to their domestic season, with Saturday's 2-0 victory over Terek Grozny lifting them to second in the Russian Premier League.
Despite losing Radamel Falcao to big-spending Monaco in the summer, Atletico still have a host of attacking talents to call upon.
Chief among them is former Barcelona attacker David Villa, who boasts a wealth of experience in European competition that could prove vital.
Another threat to Zenit will be Brazilian striker Diego Costa, who has enjoyed a fine start to the season.
The 24-year old admitted that he nearly joined English side Liverpool during the summer, but decided to stay loyal to Atletico and has been in great form ever since, finding the net four times in as many league outings.
Visitors Zenit did not travel well during last season's competition, losing four of their five away matches, but they also have a number of attacking options at their disposal.
Danny is among their key assets, with the Portuguese striker having scored six times in their last eight games. Coach Luciano Spalletti will also be hoping that Brazilian forward Hulk recovers from the hip injury that kept him out of action at the weekend.
Spalletti has been tipped as a possible replacement for Cesare Prandelli as Italy coach after the FIFA World Cup, but he insisted that he was enjoying the challenge in Russia.
"In St Petersburg I feel respected by an entire city, both as a sportsman and as a man," he said. "They helped me to work in the best possible circumstances, even during difficult moments, as the city, the fans and the club supported me.
"This is fundamental for me. I might be wrong, but I do everything with sentiment."
Zenit have not won in Spain in five previous attempts.
|Coach: D. Simeone|
for Adrián 79'
for A. Turan 86'
for Koke 89'
|Santa Fe 1 Medellin 1 (agg 3-2): Hosts win Clausura title|
|Emelec 3 Barcelona 0 (4-1 agg): Bolanos brace seals title defence|
|Pioli: Lazio did not switch off|
|No Park in South Korea´s Asian Cup squad|
|Gignac: Marseille lead ´a huge boost´|
|Simeone applauds Griezmann´s hat-trick|
|Redknapp vows to keep QPR sharpshooter Austin|
|Santiago Wanderers 1 Palestino 6 (agg 2-9): 36-year drought ends for visitors|
|Juan Aurich 2 Sporting Cristal 3 (aet, agg 4-5): Chavez hands visitors Peruvian title|
|Liga del Futbol Profesional Boliviano Review: Bolivar win title|
|Mancini plays down Lennon transfer rumours|
|Ligue 1 Review: Marseille end 2014 top of the table, Lyon leapfrog PSG|
|Kovacic has mixed emotions after Inter draw|
|Serie A Review: Lazio go third despite Inter rally, Sampdoria held|
|La Liga Review: Griezmann the man for Atleti, Villarreal gain fifth straight win|
|Primeira Liga Review: Benfica win six straight|
|Athletic Bilbao 1 Atletico Madrid 4: Griezmann hat-trick seals comeback win|
|Inter 2 Lazio 2: Hosts rally to claim draw|
|McCoist makes Rangers exit|
|Sturridge on course for January return - Rodgers|
|Liverpool getting back on track, says Rodgers|
|Wenger bemoans failure to defend set-pieces|
|Bundesliga Review: Hoffenheim enjoy big win, Freiburg falter late on|
|Zorc: Dortmund to stick with Klopp|
|Liverpool 2 Arsenal 2: Bandaged Skrtel rescues a draw|
|I have no problem with Payet, insists Bielsa|
|Eredivisie Review: Ajax leave it late, Vitesse finally win|
|Pardew rues over-zealous Newcastle approach|
|Benitez hopeful ahead of Supercoppa|
|I nearly took Johnson off - Poyet|
|Johnson revels in derby late show|
|Juventus must maintain focus, warns Allegri|
|Newcastle United 0 Sunderland 1: Johnson settles derby|
|Carlos leaves Sivasspor post|
|Dundee United 2 Celtic 1: Ciftci inspires surprise win|
|Mourinho against use of independent panels|
|Hartlepool not interested in signing Evans|
|Reed delighted with first Southampton start|
|Bremen agree Oztunali loan|
|Irvine backs Ideye to end goal drought|
|Carrick backs Falcao to kick on|
|Dortmund will come back stronger, vows Klopp|
|Bojan senior slams Barcelona|
|Eredvisie title not won yet - Depay|
|Sterling eager to catch Arsenal cold|
|Monk: Ki will be sorely missed|
|Bruce looking to recall Hull duo from loan spells|
|Allardyce: Pearson deserves time|
|Sydney 0 Wellington Phoenix 2: Burns at the double|
|Real Madrid 2 San Lorenzo 0: Spanish giants complete triumphant 2014|
|McCoist: Departures sucking life out of Rangers|
|Hargreaves urges Sterling to stay put|
|Herediano 1 Deportivo Saprissa 1 (agg 3-5): Draw hands visitors consecutive titles|
|Tribulietx basks in Auckland City´s heroics|
|San Lorenzo´s Bauza applauds Ancelotti|
|Wenger: Sanchez a Footballer of the Year candidate|
|Chelsea like United´s treble-winning team - Hargreaves|
|Ancelotti: Copa del Rey victory inspired Real´s stunning run|
|La Liga Review: Catalan clubs triumph|
|Milan on right track - Inzaghi|
|Estoril 1 Vitoria Guimaraes 0: Kleber checks visitors´ momentum|
|Eredivisie Review: PSV in Eagles demolition, AZ downed at home|
|Garcia fumes at missed handball|
|Serie A Review: 10-man Milan frustrate Roma, Cesena rescue point|
|Roma 0 Milan 0: Hosts denied despite Armero red|
|Ligue 1 Review: PSG held at home, Monaco claim fourth win in a row|
|Bundesliga Review: Bremen off bottom with Dortmund win, Augsburg beat Gladbach|
|Blanc frustrated after drab stalemate|
|League Two Review: Moore´s Hartlepool tenure begins with draw|
|Championship Review: Blackpool hit for six, Middlesbrough slip up|
|Luis Enrique enjoying Pedro´s resurgence|
|Scottish Premiership Review: Aberdeen move to second, St Mirren misery continues|
|Koeman delighted with clinical Southampton|
|Pochettino tips in-form Kane for England call-up|
|Dortmund are ´idiots´ - Klopp|
|Allardyce hails ´outstanding´ Downing|
|Young admitted fault after Agbonlahor dismissal, says Lambert|
|Pearson not concerned with speculation|
|Bruce: Hull simply not good enough|
|Everton must improve - Martinez|
|Irvine rues sloppy defending|
|Cruz Azul 1 Auckland City 1 (2-4 on pens): Plucky New Zealanders claim third|
|Austin an example for young strikers - Redknapp|
|Dyche takes pride in White Hart Lane defeat|
|Arabian Gulf League Review: Al Shabab strike late to sink Al Dhafra, top two win|
|Swansea win vindicated changes, says Monk|
|Van Gaal frustrated by dropped points at Villa|
|Paris Saint-Germain 0 Montpellier 0: Champions frustrated by Courbis´ men|
|League One Review: Wilson gains landmark win as Bristol City and Swindon falter|
|Hull City 0 Swansea City 1: Monk´s men celebrate rare away win|
|Southampton 3 Everton 0: Koeman´s side back to winning ways|
|Aston Villa 1 Manchester United 1: Visitors held despite Agbonlahor dismissal|
|QPR 3 West Brom 2: Austin treble lifts hosts out of drop zone|
|Barcelona 5 Cordoba 0: Suarez opens Liga account in emphatic win|
|Tottenham 2 Burnley 1: Lamela stunner wins it for Spurs|
|West Ham 2 Leicester City 0: Carroll, Downing seal the points|
|Werder Bremen 2 Borussia Dortmund 1: Hosts off the bottom by adding to Klopp´s woes|
|Kerala Blasters 0 Atletico de Kolkata 1: Last-gasp Rafique seals inaugural title|
|Warnock fumes over disallowed goal|
|Pellegrini hails Silva quality|
|Betis announce Mel return|
|Huntelaar signs Schalke extension|
|Juventus v Napoli: Allegri backs Tevez to make difference|
|Stoke City v Chelsea: Mourinho calls for adaptability|
|Manchester City 3 Crystal Palace 0: Silva strikes twice as champions go joint-top|
|A-League Review: City snatch Melbourne derby honours, Glory pull further clear|
|Mancini: Inter can finish third|
|Sterling revels in Golden Boy award|
|Pellegrini: You never win a title in December|
|Rodgers bemoans Sanchez snub|
|Ayew confident Marseille can beat title rivals|
|Mercier: San Lorenzo won´t roll over to Real Madrid|
|Lukaku: I´m still 21|
|Mainz bemoan ´tragic´ loss to Bayern|
|Rojo ruled out for Villa trip|
|Lopetegui thrilled with Porto response|