Jose Mourinho suffered his first Premier League defeat since returning to Chelsea following a 1-0 loss against Everton at Goodison Park.
Mourinho's men were guilty of missing a host of chances and were made to pay for their wastefulness when Steven Naismith grabbed the winner on the stroke of half-time to hand Roberto Martinez his first Premier League victory as Everton manager.
Debutant Samuel Eto'o and Andre Schurrle were particularly guilty of missing good opportunities for Chelsea in the first half.
And Naismith pounced from Nikica Jelavic's header back across goal in first-half injury time.
Substitute Oscar felt he should have been awarded a penalty in the second half but referee Howard Webb waved away the protests.
Mourinho handed a first competitive start to transfer window signing Eto'o, with Fernando Torres dropping to the bench.
Everton gave a debut to Gareth Barry but fellow new boy James McCarthy had to settle for a place among the substitutes.
In a lively opening, Eto'o almost opened his Premier League account as early as the fourth minute.
Ramires found space on the right and his pin-point cross was met by the Cameroonian but he could only head over the bar from eight yards.
At the other end, Jelavic was equally as wasteful. Ross Barkley won possession in midfield and he supplied Naismith, whose excellent cross was met by the Croatian but he headed tamely at Petr Cech.
Tim Howard was given a huge reprieve in the 29th minute after a small lull in clear-cut openings.
Howard's attempted pass out of defence was intercepted by Eden Hazard. He centred to Eto'o, who looked destined to tap into the empty goal only to be denied by a wonderful sliding interception from Barry.
Chelsea continued to press and Mourinho was visibly frustrated as two good opportunities were not converted. First, Ramires flicked a ball in the air and volleyed at goal only to be denied by Howard.
The Brazilian then broke free again and prodded into the path of Schurrle, but the German blasted well over when one-on-one with the goalkeeper.
And Chelsea were made to pay for their profligacy in front of goal when Naismith notched the opener on the stroke of half-time.
Barkley crossed to Jelavic at the back post and he headed back across goal to the Scot, who could not miss when heading home on the goal line.
The second half started in similar fashion with Chelsea creating but unable to break down Everton's resistance.
Schurrle broke free but chipped over Howard into the side netting, before Howard parried a Hazard effort into the path of Eto'o but he failed to connect as the ball went harmlessly wide.
Oscar replaced Juan Mata, and the Brazilian thought he should have had a penalty in the 58th minute.
He ran across Sylvain Distin and was felled in the box but Webb was unmoved. Replays suggested Oscar may have had legitimate claims for a spot-kick as he appeared to touch the ball before the Frenchman.
With 20 minutes remaining, the lively Ramires stretched for a Branislav Ivanovic cross but he could only fire into the side netting.
Everton looked threatening on the counter attack as Chelsea searched for the equaliser and had a series of corners before Kevin Mirallas had an effort beaten away well by Cech.
The home fans thought their team had a late penalty when Seamus Coleman was brought down by Hazard, but the incident occurred just outside the box.
And they came desperately close to a second in the 88th minute when Leighton Baines saw his free-kick rebound off the crossbar.
|Coach: Roberto Martínez|
for N. Jelavić 66'
for S. Naismith 89'
for K. Mirallas 90+2'
|Pioli not concerned by Simeone´s Inter comments|
|Poyet: It would be a pleasure to sign Tevez|
|Celtic charged by UEFA over crowd disturbances|
|Not extending Man United stay my only regret - Larsson|
|Aubameyang´s mum: He always spoke about Madrid, never Barcelona|
|AC Milan sale delayed until March|
|Police horse burger thrower fined|
|Nolito comfortable with Guardiola´s rotation policy|
|Ajax expect in-demand Bazoer to exit|
|Not even the Golden Boot would get me an England recall, says Defoe|
|MLS MVP Villa has no interest in Premier League move|
|Vidal: I never had a problem with Luis Enrique|
|Ancelotti not keen on Madrid Champions League reunion|
|Zabaleta: Guardiola needs Iheanacho more than ever|
|Ranieri not fearful of Foxes chop|
|Celtic fan arrested for throwing burger at police horse|
|Dad-to-be Lewandowski reveals baby news with goal celebration|
|Klopp´s Liverpool watched Barca at Camp Nou|
|Wenger braced for tough last-16 draw|
|Roberts buoyed by Guardiola acclaim|
|Gladbach´s Alvaro Dominguez retires at 27|
|Simeone satisfied with aggressive Atletico|
|Emery aims to bounce back after European disappointment|
|Madrid demand ´maximum respect´ for Ronaldo|
|No pressure on Iheanacho to fill Aguero´s boots - Guardiola|
|Cocu praises PSV effort despite European exit|
|Ancelotti hoping for confidence boost|
|Gunes takes blame for Besiktas thrashing|
|Vitoria upbeat despite Napoli defeat|
|Arda Barca future brighter after hat-trick|
|Le Tissier makes ´naked massage´ claims|
|´He has a smell for the goal´ - Wenger hails hat-trick hero Lucas|
|Guardiola to assess Roberts situation at end of season|
|Napoli have no fear - Reina|
|Iheanacho shines but Guardiola concerns lie deeper|
|Barcelona pass masters set new Champions League benchmark|
|Dybala ready to return for Juventus|
|PSV 0 Rostov 0: Russians seal Europa League spot with stalemate|
|Paris Saint-Germain 2 Ludogorets 2: Di Maria rescues draw but PSG miss out on top spot|
|Benfica 1 Napoli 2: Super-sub Mertens seals top spot|
|Dynamo Kiev 6 Besiktas 0: Nine-man visitors crash out|
|Messi fails to match Ronaldo´s Champions League record|
|Basel 1 Arsenal 4: Lucas hat-trick helps Gunners clinch top spot|
|Manchester City 1 Celtic 1: Roberts scores against parent club|
|Bayern Munich 1 Atletico Madrid 0: Lewandowski free-kick the difference in Bavaria|
|Barcelona 4 Borussia Monchengladbach 0: Arda hat-trick lights up Barca procession|
|Zidane ´more sympathetic´ than other Madrid coaches, says Ramos|
|Bartra eager to square up against old rivals Madrid|
|Pardew´s job is ´totally safe´ - Palace chairman|
|Shelvey and Dummett red card appeals successful|
|Lopes doubtful for Sevilla clash due to lack of sleep|
|Real Madrid test will bring the best out of Aubameyang - Tuchel|
|Slutsky to leave CSKA Moscow|
|Genesio hails Valbuena character|
|Spurs hungry for Europa League football - Vertonghen|
|Deschamps claims Pogba is unlikely to ever win Ballon d´Or|
|Xavi: Barca have not lost their essence|
|Strootman banned for sparking Rome derby brawl|
|Mkhitaryan accepts blame for slow start at United|
|New York City star Villa named MLS MVP|
|Ramos distances himself from tax avoidance scandal|
|Witsel casts doubt on January Juventus switch|
|Schmidt has faith in misfiring Hernandez|
|Gabriel not happy at Inter, says agent|
|PSG just another game for returning Balotelli|
|Dortmund eye top spot and a goalscoring record - Champions League in Opta numbers|
|Southgate bids farewell to England assistant Lee|
|Europa League can help Spurs end Wembley hoodoo - Pochettino|
|Watmore´s season ended by injury|
|Zidane: Dortmund clash is a final|
|Gotze to miss Madrid test|
|Lacazette to ponder Lyon future|
|Griezmann lauds ´world class´ Aubameyang|
|Sporting´s in-demand Gelson going nowhere, claims agent|
|FA appoints new lead QC as scope of child sexual abuse review is outlined|
|Hodgson: England players failed to grasp my instructions|
|Xhaka pleads for time to settle in at Arsenal|
|Kluivert urges PSG to learn from Montpellier humbling|
|Augenthaler tips Bayern captain Lahm to play on|
|Rodgers: Celtic growing in confidence in Europe|
|Brazil-Colombia friendly proposed to raise money for Chapecoense|
|If you don´t play, you can´t shine - Hummels urges Mourinho to believe in Mkhitaryan|
|Ronaldinho ready to help Chapecoense|
|United can still finish top four - Guardiola|
|Bale´s ankle ´feeling better every day´|
|Sarri: Napoli in Lisbon to win|
|Watford and West Brom hit with FA charge|
|Karanka delighted with Boro´s game management|
|Middlesbrough 1 Hull City 0: Ramirez sinks sorry Tigers|
|Can Arsenal break the Basel curse? The Champions League in Opta Numbers|
|Everton confirm serious knee injury for Bolasie|
|Stam set for Old Trafford reunion in FA Cup third round|
|Sanchez, Ozil contract talks not just about money - Wenger|
|It is normal my son says I´ll coach Inter, I will - Simeone|
|Chapecoense confirmed as Copa Sudamericana champions|
|Sullivan backs Bilic to reverse Hammers´ fortunes|
|It was close...very close - Hummels reveals level of Man United interest|
|What You Might Have Missed: An FA Cup comeback of all comebacks and Monaco can´t stop scoring|
|Preston fans to be refunded from Beckford, Doyle fight fines|
|In-demand Lindelof ´happy to stay at Benfica´|
|FA charges City and Chelsea for late fracas|
|Darmstadt sack coach and sporting director after dismal run|
|Anyone who says they would not sign Messi is a liar! - Caballero|
|Roberto warns Madrid: Barcelona will cut the gap|
|Emery: Champions League top spot was always PSG´s priority|
|Guardiola brands Sanchez transfer rumours as lies|
|Boateng ruled out of Bayern´s clash with Atletico|
|FA confirms four-game ban for Aguero|
|Blatter FIFA ban remains after CAS dismisses appeal|
|Luis Enrique: I don´t give a damn about beating Gladbach|
|Emre hits out at Allardyce´s style... and slams his chewing gum|
|Bravo the world´s best goalkeeper, says Pellegrini|
|Ibrahimovic: I know how to kick someone and make him fall asleep|
|Barcelona and Real Madrid would not win 5-0 in Ligue 1 - Verratti|
|Seedorf out, Eriksson in at second-tier Chinese club|
|Tevez to China? Shanghai Shenhua claim ´breakthrough´ in talks|
|´English football is not more pure´ – Pochettino will not slam Alli for ´dive´|
|Gudjohnsen offers his services to Chapecoense|
|Savicevic: Champions League qualification paramount for Milan|
|Wenger: West Ham could take two years to settle|
|River Plate play in green as tribute to Chapecoense|
|Roberto Carlos open to coaching in A-League|
|Wenger confident there is more to come from Arsenal|
|Kane wants to see out career at Tottenham|
|Aguero challenge labelled ´crazy´ by disappointed Cahill|
|Mourinho ´has nothing to hide´ over tax affairs|