Gareth Bale could make his Real Madrid bow on Saturday as they travel to Villarreal, with both having made 100 per cent starts to the term.
Following his world-record transfer from Tottenham, the Wales international is expected to be involved for Carlo Ancelotti's side, having featured for his country against Serbia on Tuesday.
The 24-year-old could even line-up at full back after Marcelo and Fabio Coentrao both suffered injuries during the international break.
Bale has admitted he might not be fully fit, but insisted he would be happy to play any role his manager needs him to on Saturday.
"We have to wait until the match day to see whether I'm picked or not," he said. "But hopefully I can get my fitness up straight away and get a place in the team.
"I have spoken to the boss about where I'm best on the pitch but I will play anywhere I'm asked."
Both sides have started the season with three wins out of three, but with Madrid dominating their opponents in recent meetings, they will be favourites to maintain their winning start.
Real have won 17 of their 26 meetings, and have not lost any of their last six encounters.
Villarreal only lost seven games on the way to a second-place finish and automatic promotion from the Segunda Division last season and they have started the new campaign well.
The Estadio el Madrigal has been a tough place for teams to visit in the past 12 months with only three sides having left with all three points, and captain Bruno Soriano remains confident they can surprise Real.
"It's a chance to show that we can compete with anyone and that we can fight against a team like Madrid," he said.
"Last year, we were dreaming about playing these teams and now the opportunity has arrived and we want to put in a great performance.
"Personally I prefer it if an opponent is at full strength and that the best come so we can take them on.
"Although even if Madrid has some players out, I am sure they will have the same level of quality."
Xabi Alonso (foot) and Raphael Varane (knee) will definitely be missing for Madrid, however Cristiano Ronaldo and Isco are expected to be available having taken part in training on Thursday.
Bojan Jokic (hamstring) and Francisco Farinos (Achilles) are doubts for the hosts having already missed the opening matches of the season.
|9||G. dos Santos||70'|
for Jonathan Pereira 65'
for Trigueros 71'
for G. dos Santos 75'
|Putin: Blatter deserves a Nobel prize|
|Howe: Swansea a benchmark for Bournemouth|
|New Parma to play in Serie D|
|Mata vows to hit the goal trail at United|
|Drogba ´perfect fit´ for Montreal|
|Berahino ´not yet´ ready for Tottenham - Irvine|
|Romero lauds caring Van Gaal|
|Jese flying at Real under Rafa|
|Sampdoria unwilling to pay €10m for Balotelli|
|Mourinho talks up Arsenal title chances|
|Hull sign Ryan Taylor, Sam Clucas|
|Kane, Pochettino hail MLS All-Star test|
|Di Santo sorry for swift Werder departure|
|Mourinho tells Ronaldo: Team honours come first|
|Khedira returns to Juve training|
|Celtic v Qarabag: Champions League return of utmost importance, says Collins|
|Pellegrini: Jovetic had to go|
|Manquillo completes Marseille move|
|Schalke reject Juve´s Draxler bid|
|Blanc: Di Maria deal ´close´|
|Di Santo debut ends in stalemate|
|Fire sign Drogba, trade him to Montreal Impact|
|FIFA and UEFA welcome ruling on third-party ownership|
|Juve kick off title defence against Udinese|
|Stoke sign free agent Afellay|
|Benitez confident Ramos will stay|
|Fenerbahce issue warning to fans|
|UEFA Champions League Preview: De Boer confident Ajax are ready for Vienna test|
|Bility: I am the favourite for FIFA presidency|
|Pienaar to miss start of season|
|Vietnam 1 Manchester City 8: Sterling shines as tourists run riot|
|All-Star Keane relishing Spurs clash|
|Shaun Wright-Phillips joins brother Bradley at Red Bulls|
|Inter 0 Real Madrid 3: Rodriguez stunner caps comfortable win|
|Villa sign Ayew|
|Watford complete Berghuis transfer|
|Robben returns to Bayern training|
|Pulis anxious to make West Brom additions|
|David Luiz eager to welcome ´fantastic´ Di Maria|
|Fernando injury free ahead of new campaign|
|Hummels blames weight issues for poor season|
|Defoe hoping for early Sunderland goals|
|Depay hints at identity of ´surprise´ United striker|
|Tigres UANL v River Plate: Hosts look to bounce back and make history|
|Crespo set for Villa move|
|Terry: I would never join a Premier League rival|
|Van Gaal coy on United future|
|Romero to cover potential De Gea exit - Van Gaal|
|Uruguay win men´s football gold at Pan Am Games|
|Pirlo thanks New York City fans for ´beautiful´ welcome|
|Mexico capitalised on ´the mistakes we made´ - Schafer|
|Herrera delighted with Mexico display|
|MLS Review: Whitecaps build happy home, Pirlo debuts|
|Guardado wins Golden Ball at Gold Cup|
|NZF confirms Olympics disqualification appeal|
|Jamaica 1 Mexico 3: CONCACAF giants complete form turnaround|
|New York Red Bulls 2 Benfica 1: Another scalp for MLS side|
|Romero signs with United|
|Moghreb Tetouan 1 Al Hilal Omdurman 1: Visitors go top|
|Van Gaal rules out Ronaldo bid|
|Pique open to Barca captaincy|
|Pirlo makes MLS bow in thrilling NYC victory|
|Coutinho and Can return for Liverpool U21s|
|Walcott deal ´closer´, says Wenger|
|Arsenal 1 Wolfsburg 0: Walcott the match-winner in Emirates Cup finale|
|Di Santo links up with Schalke squad|
|Lukaku treble sinks Hearts|
|Benitez again refutes Ronaldo rift rumours|
|Pepe sure Ramos will stay at Real|
|City target De Bruyne named Germany´s Player of the Year|
|Montero spoils McCarthy´s Palace debut|
|Lyon 0 Villarreal 2: Soriano, Baptistao seal comfortable win in Emirates Cup|
|Wijnaldum on target as Newcastle are held|
|Mourinho: Rivals trying to buy the title|
|Jovetic set for Inter medical|
|RFS in ´denial´ over racism issue, claims Football Against Racism in Europe|
|Salah not staying at Chelsea - Mourinho|
|Mbemba closes in on Newcastle switch|
|Ibrahimovic: Di Maria will take PSG to another level|
|Delph: Don´t compare me to Pogba|
|Dundee United sign Sneijder|
|Morata relishing new-look Juve strikeforce|
|Strachan "not scared" of England after World Cup qualifying draw|
|Brazil claim football, basketball, handball gold in Toronto|
|Lampard´s debut delayed again, Pirlo ready to play|
|Mourinho open to Premier League matches in US|
|MLS Review: Texas unites to hurt Galaxy|
|Luis Enrique: United can emulate Barca revival|
|Van Gaal singles out Januzaj, hails United´s forwards|
|Blanc still hopeful PSG will sign Di Maria|
|Irish international Cunningham seeks Bristol City exit|
|Italy embracing Spain challenge in World Cup qualifying|
|Dos Santos brothers in doubt for Gold Cup final|
|PSG 1 Chelsea 1 (aet, 5-6 on penalties): Courtois clinches victory for Mourinho´s men|
|United States 1 Panama 1 (aet, 2-3 on penalties): Mejia denies hosts third|
|ES Setif 1 Al Merreikh 1: Sudanese deny title-holders at home|
|CONCACAF admit referee errors in Gold Cup semi-final|
|Dutch favourites in Group A - Deschamps|
|Barcelona 1 Manchester United 3: Rooney, Lingard and Januzaj maintain winning start|