The Football Association of Ireland have confirmed that Giovanni Trapattoni has left his post as Republic of Ireland manager.
Trapattoni's departure comes after consecutive defeats against Sweden and Austria left Ireland facing an uphill task to qualify for the 2014 FIFA World Cup.
Ireland can still qualify for the finals despite those losses, but would need a remarkable turnaround to have any chance of reaching the finals in Brazil.
They sit six points adrift of second-place Sweden with two games to go, and possess an inferior goal difference ahead of meetings with Group C leaders Germany and minnows Kazakhstan.
Trapattoni did lead Ireland to the UEFA European Championships in 2012, however he could not guide them past the group stage, suffering defeats to Croatia, Spain and Italy.
Ireland's prospective exit from World Cup qualifying will mean that they have not reached the finals of football's biggest tournament since 2002, when they made it to the round of 16 under the guidance of Mick McCarthy, who has been linked with a return to the post.
This newest failure has signalled the end for Trapattoni, with assistant Marco Tardelli also leaving his post.
"The Football Association of Ireland, Giovanni Trapattoni and Marco Tardelli today (Wednesday) announced that following an amicable meeting this morning, they have parted company by mutual consent," an FAI statement read.
However, despite his departure, Trapattoni was quick to express his admiration for the Irish fans.
"I want to thank everyone in Ireland who has given us their support during our time here which has always meant a lot to us," he said.
"We leave this country with emotion because we understand the Irish supporters who have a well-deserved international reputation and they have our utmost respect.
"I would also want to thank all FAI staff members, including the backroom team and the players who have been great to work with during the last three campaigns.
"I wish them well in the future and hope that the job we have done leaves everything in a good place for my successor to take over."
|Hill backs Ramsey for QPR job|
|Ancelotti confident of Real revival|
|Allegri rues late Llorente miss in Juve triumph|
|Juve sent a warning - Pirlo|
|Inverness Caledonian Thistle 2 Dundee United 1: Ofere and Williams keep European dream alive|
|Juventus 2 Real Madrid 1: Spot-on Tevez earns first-leg lead|
|Sturridge hip surgery a success|
|Coloccini calls for unity as Newcastle target survival|
|Doumbia cleared to make Milan trip|
|Harper calls for Hull unity|
|Guardiola not distracted by Barca homecoming|
|No defence can stop Barca star Messi - Guardiola|
|Neuer ready to face Barca strike trio|
|Napoli v Dnipro: Benitez seeks to make experience count|
|Jones ready for United return|
|Injury rules Oscar out of Brazil´s Copa squad|
|Mazinho proud ahead of Barca v Bayern contest|
|Sevilla v Fiorentina: Kolodziejczak confident ahead of semi-final test|
|Skipper Soriano set for Villarreal return|
|Martinez wary of Pienaar risk|
|AFC Champions League Review: Holders Western Sydney out due to last-gasp Seoul winner|
|Barca focused ahead of Pep return - Luis Enrique|
|Messi has ´no problem´ with Luis Enrique|
|Relegated Tranmere appoint Brabin|
|Ujah agrees Werder transfer|
|Magath backs Guardiola to remain at Bayern|
|Mathieu out of Bayern clash|
|Burnley appeal Duff dismissal|
|Setif drawn in Algeria-heavy Champions League group|
|Terry calls for new Drogba deal|
|Saul agrees bumper Atletico deal|
|Arsenal need to finish season strongly - Wenger|
|New Bilbao deal for Gurpegi|
|Pepe puts Morata friendship aside for Champions League match-up|
|Terry: Too long between titles|
|Hazard can be as good as Messi, Ronaldo - Fabregas|
|Carlisle ´deeply ashamed´ about suicide attempt|
|Tevez planning to win Champions League with Juve|
|Blatter ´knows absolutely nothing´ - Maradona|
|Allegri: Ancelotti a smart man|
|Sunderland academy coach to manage Oldham|
|Primeira Liga Review: Braga secure Europa League berth|
|Bruce backing Hull to respond against Burnley|
|Almeria 2 Celta Vigo 2: Bifouma, Zongo inspire hosts´ comeback|
|Arsenal can mount title bid - Wenger|
|Turkish Super Lig Review: Besiktas and Galatasaray remain locked at the top|
|Cagliari 4 Parma 0: Festa revival back in gear|
|Hull City 1 Arsenal 3: Sanchez at the double as visitors close on second|
|Blackpool - Huddersfield game will not be finished|
|Allegri vindicated by Juventus success|
|Russian Premier League Review: Krasnodar close the gap as Zenit slip up|
|Al Ahly dismiss Garrido|
|MLS Preview: Kinnear returns to Dynamo with Earthquakes|
|Ancelotti all out for victory against Juventus|
|Ramires recovering well after sickness|
|Prince Ali would back rival FIFA candidate to oust Blatter|
|Barcelona v Bayern Munich: Guardiola makes Camp Nou return|
|Kruse a target for Wolfsburg - Allofs|
|Fletcher backing Bournemouth to ´surprise a few´|
|Bremen agree deal with Fritz|
|Carver gets Newcastle backing|
|Blaszczykowski suffers groin tear|
|Boateng warns of Barca ´storm´|
|Brouwers agrees Gladbach extension|
|Benzema to miss Turin trip|
|England great Jimmy Greaves suffers stroke|
|Cabaye concerned by bit-part role at PSG|
|Parry: Anfield expansion a major boost|
|Ki targets Arsenal win and seventh spot|
|Pirlo eyes potential Champions League swansong|
|Mourinho rounds on critics after clinching title|
|Henderson: Liverpool can push on without Gerrard|
|Lack of goals a concern for Van Gaal|
|Hard to keep Benteke - Bacuna|
|MLS Review: Sporting KC end Chicago streak, Martins brace furthers NYC pain|
|Copa Libertadores Preview: River eye revenge in Superclasico|
|Garcia lauds ´impressive´ Roma|
|Pavon goal scores him a BMW for a month|
|Boca beat River in Superclasico|
|Inzaghi to blood youth after third straight Milan defeat|
|Blanc urges PSG to ´remain vigilant´|