Second meets third in League Two on Saturday as Burton Albion host Oxford United at the Pirelli Stadium.
Chris Wilder's men are level on points with Burton but sit in second thanks to their superior goal difference.
The two sides are unbeaten so far this term and a win for either could put them top, if leaders Chesterfield drop points against rock-bottom Accrington Stanley.
However, Paul Cook's men will be overwhelming favourites for the tie against his former employers, with the visitors having picked up just one point from their opening five fixtures.
Cook's side clinched top spot with a 2-0 win over Portsmouth last time out but he believes there are still improvements to be made.
"I never try and kid our fans and make out that everything’s great, we haven’t played well the last couple of games but we’ve got two fantastic results," he told the club's official website.
"We must work very hard in training, we must be bright with our passing, we must be more inventive and we must work harder to win games."
With just two points separating Oxford in second and Southend United in seventh, the four teams in the play-off spots will be aware of the importance of a win.
Fourth-place AFC Wimbledon travel to Bootham Crescent to face a York City side without a win since the opening day while, a place below, Exeter City travel to Dagenham and Redbridge.
Fleetwood Town will look to bounce back from their 2-0 defeat to Wimbledon when they welcome Torquay United as Southend seek to avoid three consecutive defeats against a buoyant Morecambe who have won their last two league matches.
Hartlepool United, fresh from their 5-0 Football League Trophy win over Bradford City on Tuesday, can pick up their first win of the season in the league against Wycombe Wanderers at Victoria Park.
Forward Andy Monkhouse believes his team-mates can bring their belief from the victory into the league, where they are yet to find the net this term.
"By the end (of the Bradford game) it could have even been more than five goals," he told the club's official website.
"Towards the end everyone wanted the ball, people were trying tricks, we were all running and tackling – I think the belief was there for all to see."
Northampton Town hover precariously above the drop zone, with just one win to their name this season, but Aidy Boothroyd's men can move clear of the bottom two when they host Scunthorpe United.
Cheltenham Town are in similar trouble at the bottom and will need to keep David Connolly quiet when they take on Portsmouth, with the 36-year-old having struck four times so far this season.
The two sides promoted from the Conference Premier last season, Newport County and Mansfield Town, meet for the first time in the league on Saturday, having made impressive starts to their domestic campaigns.
Both have lost just once in their five games and can move into the top seven with victory.
South west neighbours Plymouth Argyle and Bristol Rovers meet at Home Park while there is a Lancashire derby at Spotland as Rochdale host Bury.
|Coach: G. Rowett|
for M. Symes 37'
for R. Howe 76'
for L. Bell 76'
|Kiessling calls for Leverkusen response|
|Matuidi: Cavani on par with Ibrahimovic|
|Yeboah set to join Borussia Monchengladbach|
|Rooney a ´chance´ to face West Ham|
|FIFA Club World Cup Preview: Bayern Munich v Raja Casablanca|
|Benzarti praises ´extremely talented´ Raja Casablanca|
|Ranieri unsure over Falcao return|
|Coupe de La Ligue Wrap: Cavani leads PSG to dramatic win|
|Copa del Rey Wrap: Real Madrid through as Sevilla crash out|
|Tottenham job appeals to Sherwood|
|Sherwood gutted after defeat|
|Hughes: United worthy winners|
|Moyes pleased to see United weather storm|
|Allardyce hails West Ham fight|
|Coppa Italia: Juventus 3 Avellino 0|
|Manchester clubs kept apart in League Cup semi draw|
|League Cup: Tottenham 1 West Ham 2|
|League Cup: Stoke City 0 Manchester United 2|
|FIFA Club World Cup: Raja Casablanca 3 Atletico Mineiro 1|
|Sheffield Wednesday, Wigan abandoned due to heavy rain|
|United face anxious Rooney wait over injury|
|Messi making good progress|
|Ramos ban overturned|
|Osvaldo charged by FA|
|In-demand Ince offered new Blackpool deal|
|Molde confirm Solskjaer approaches|
|Kramer keen to continue home record|
|Rodgers: Henderson has potential to get even better|
|Ruiz on Anderlecht´s radar|
|Swansea, Hull fined by FA over player behaviour|
|Leeds keen on re-signing Gradel|
|Leverkusen announce Ryu deal|
|Ribery named Bundesliga Player of the Year|
|Moyes: No Zaha interest|
|Barcelona, Real Madrid in European Commission investigation|
|Basel: No Tottenham approach for Yakin|
|Chelsea set for Guarin bid, agent claims|
|Lewandowski has Dortmund goal concerns|
|Pogba, Pirlo will not sign before Christmas, says Marotta|
|Guardiola convinced to join Bayern after ´meat´ and greet|
|Martinez: Everton seen as a ´perfect´ loan destination|
|Anderlecht ´perfect´ for Defour, says Van Holsbeeck|
|Watford appoint Sannino|
|Sakho feels ´lucky´ to play with Suarez|
|Lippi: Too many teams competing in Club World Cup|
|Moyes ´told Welbeck to learn from Rooney´|
|I would kill myself over match-fixing, says Gattuso|
|Hughes dismisses calls for Januzaj protection|
|Aguero ´could miss up to two months´|
|Guardiola lauds Ballon d´Or nominee Ribery|
|Liverpool open Suarez contract talks|
|Copa del Rey Wrap: Barcelona, Levante cruise through|
|A-League Preview: Derby date beckons for winless Heart|
|Pearson upbeat despite Leicester defeat|
|Poyet urges Sunderland to build on Chelsea win|
|Mourinho rues missed chances|
|Pellegrini proud of professional Manchester City|
|Bayern on another level, says Beckenbauer|
|League Cup: Sunderland 2 Chelsea 1 (aet)|
|League Cup: Leicester City 1 Manchester City 3|
|FIFA Club World Cup: Guangzhou Evergrande 0 Bayern Munich 3|
|Zenit and Olympiacos punished with partial stadium closures|
|Sherwood wants positive reaction|
|Ancelotti expected La Liga title fight|
|Moffat charged over betting allegations|
|Wilson appointed at Barnsley|
|Wilshere charged by FA|
|Gattuso determined to clear his name|
|Moyes slams sacking culture|
|Mackay refuses to resign despite owner criticism|
|Redknapp reluctant to take Taarabt back|
|Amat pleased with development|
|Hughes optimistic of League Cup progression|
|Perez: No bids for Di Maria|
|FIFPro demand transfer system overhaul|
|Edwards sacked by Perth Glory|
|Allardyce not fearing the sack|
|Howson commits to Norwich|
|Tevez resigned to Argentina snub|
|SFA uphold Butcher´s one-match ban|
|Zapata rules out United switch|
|European Ombudsman calls for action on Spanish tax complaint|
|Albrighton eyes new Villa deal|
|Bale to miss Copa del Rey clash with ´small injury´|
|Pardew will bide his time in January|
|Kreuzer confident of Hamburg improvement|
|Van der Sar: Moyes can turn United around|
|Maradona backs Ronaldo for Ballon d´Or|
|Tottenham warned off Klinsmann|
|Costa Rica Primera Division: Alajuelense 0 Herediano 0|
|Lyon wary of Chornomorets Odesa|
|Guardiola talks up Lippi, Evergrande|
|Chile Primera Division Wrap: Chile, Deportes Iquique reach final|
|Garcia laments defensive mistakes|
|La Liga: Real Valladolid 3 Celta Vigo 0|