Mexico and Honduras meet at the Azteca Stadium on Friday in a match that will have huge implications for the CONCACAF qualifying group.
With the top three nations in the group guaranteed a place at the 2014 FIFA World Cup, Mexico are currently in pole position to secure third spot.
Honduras, who sit fourth, are a point behind Mexico but a win for Jose Manuel de la Torre's men would give them breathing space in their bid to qualify automatically for their sixth World Cup in a row.
Luis Fernando Suarez's side drew 2-2 with Mexico in the reverse fixture in March but Honduras goalkeeper Donis Escobar believes that his team-mates can go one better this time and leapfrog their opponents in the standings.
"There are a lot of experts who are going against us, but with a team fully focused, there are no obstacles," he told the official CONCACAF website.
"There is nothing impossible. It can be against the fans, the altitude, or that they are strong at home, there is nothing easy.
"The mindset that we have is that we come into this game mentally strong and we'll take to the field 100 per cent sure that things are going to go well.
"The mindset that we have is if we can achieve and earn four points (from the next two qualifiers), that would put us on the doorstep of qualifying."
Defeat for Mexico, who have drawn five of their six qualifiers so far, with four of those ending 0-0, would mean that Honduras jump above them, while also handing Panama the chance to move into fourth.
The fourth-placed team at the end of the group will meet Oceania winners New Zealand in a two-legged play-off, with the winners heading to Brazil.
Panama, who reached the final of the Gold Cup in July, are without a win in three qualifiers but will be favourites to pick up maximum points against bottom side Jamaica.
One of Jamaica's two points in the campaign came from their 1-1 draw with Julio Dely Valdes' side and Panama will need to improve on their recent form if they are to pick up the win, having failed to score in their last three qualifiers.
Friday's other clash sees first face second, as Gold Cup champions USA travel to Costa Rica looking to make it three wins in a row.
The US have dropped points just twice in the group so far but Costa Rica have been almost as impressive, going on a four-game unbeaten run since losing to Jurgen Klinsmann's side in March.
Klinsmann could be without Jozy Altidore, who missed club side Sunderland's Premier League fixture against Crystal Palace with a hamstring injury.
The 23-year-old has scored three of his country's last five goals in qualifying and will be assessed prior to the match.
|G. dos Santos|
|Coach: J. de la Torre|
for C. Giménez 56'
for Á. Reyna 66'
for G. Torrado 69'
|Reus blow for Dortmund|
|Mulvey leaves Roar post|
|Shakhtar Donetsk v Athletic Bilbao: Bernard eyes fast start|
|Forster urges Southampton to build|
|Sporting v Maribor: Montero out to continue hot streak|
|Schalke v Chelsea: Chance of revenge for Di Matteo|
|Manchester City v Bayern Munich: Pellegrini putting pressure on himself|
|Mourinho guards against Chelsea complacency|
|Rodriguez urges Real focus|
|Paris Saint-Germain v Ajax: Dutch outfit quietly confident|
|APOEL v Barcelona: Xavi seeks further improvement|
|Gotze basks in Bayern form|
|Tevez wants domestic form replicated in Europe|
|Mixed news on Naismith for Everton|
|Central Coast Mariners 0 Adelaide United 2: Sanchez nets brace for visitors|
|Can full of praise for Gerrard|
|BATE v Porto: Visitors eye top spot|
|CSKA Moscow v Roma: Italians eye qualification|
|Simeone lauds Atletico display|
|Messi the best ever - Luis Enrique|
|Eredivisie Review: Feyenoord make Peersman pay, Ajax beat Heerenveen|
|La Liga Review: Real Madrid, Barcelona win big|
|Allegri lauds Pogba performance|
|Messi pays homage after record-breaking day|
|Messi the record breaker|
|Serie A Review: Top two both victorious|
|Taylor hints that knee injury not as bad as first feared|
|Ligue 1 Review: Lyon stumble against Bastia|
|Van Gaal critical of United despite win|
|Lazio 0 Juventus 3: Pogba and Tevez star as champions dominate|
|Wenger frustrated by wasteful Arsenal defeat|
|Barcelona 5 Sevilla 1: Messi breaks La Liga record as Barca cruise|
|Garcia delighted with Ljajic display|
|League One Review: Swindon close the gap at the top, Yeovil off the bottom|
|Messi breaks La Liga goal record|
|Ancelotti: Isco a ´perfect´ Modric replacement|
|Bundesliga Review: Wolfsburg slip helps move Bayern well clear|
|Rooney revels in success of counter-attack ploy|
|Tiago: Malaga scalp proves we´re great|
|Arsenal 1 Manchester United 2: Rooney seals Van Gaal´s maiden away win|
|Reus injury angers Klopp|
|Schweinsteiger pays tribute to Bayern fans|
|Pellegrini salutes Toure´s attitude|
|Hughes laments Stoke´s slow start|
|Allardyce frustrated after Everton defeat|
|We deserved more - Redknapp|
|Irvine: Yacob can have no complaints|
|League Two Review: Luton run ended by Burton, Wycombe go top|
|Eibar 0 Real Madrid 4: Relentless Real win again|
|Poyet defends Cattermole over Cambiasso tackle|
|Dyche hails Burnley resolve|
|Martinez hails ´satisfying´ Everton triumph|
|Pearson sure of Leicester survival|
|Gomis earns Monk forgiveness for late miss|
|Pardew full of praise for Sissoko|
|Mourinho lauds ´beautiful´ Chelsea display|
|Scottish Premiership Review: Guidetti strikes again for Celtic, top four all win|
|Championship Review: Bamford denies Mackay´s Wigan, Derby extend lead|
|Aston Villa v Southampton: Koeman eyes international swagger|
|Newcastle United 1 QPR 0: Skipper Sissoko seals fifth straight win|
|Leicester City 0 Sunderland 0: Hosts´ goal drought continues|
|Stoke City 1 Burnley 2: Ings at the double as visitors hold on|
|Atletico Madrid 3 Malaga 1: Unconvincing champions halt in-form visitors|
|Everton 2 West Ham 1: Osman celebrates landmark with winner|
|Manchester City 2 Swansea 1: Toure seals comeback win for champions|
|Chelsea 2 West Brom 0: Yacob sees red as leaders march on|
|Paderborn 2 Borussia Dortmund 2: Reus injury leads to Dortmund capitulation|
|Bayern Munich 4 Hoffenheim 0: Champions move seven clear|
|Bielsa not concerned by Marseille investigation|
|Mancini buoyed by Inter preparations|
|Benitez rules out Liverpool return|
|Hertha prepared for Kalou absence|
|Montella confident despite Fiorentina pressures|
|Injured Alex out of Milan derby|
|Pochettino wants versatility from Dier|
|Van Gaal will not take risks with Falcao fitness|
|A-League Review: Sydney keep pressure on at top|
|K. League Review: Sangju Sangmu all but down, Gyeongnam remain in danger|
|J.League Review: Gamba deny title-chasing Urawa, Ventforet ensure safety|
|Rabiot thrilled with PSG return|
|Sterling wants long Liverpool stay|
|Poyet: I thought Cattermole would ´shoot´ me|
|Simeone: Cerci interest compliments Atletico|
|Blanc: ´I was confident´ of PSG win|
|Silva sidelined for crucial City-Bayern clash|
|Lambert would ´love´ to keep Vlaar, slams agent|
|Championship Review: Brentford up to fourth, Reading lose again|
|Athletic Bilbao 3 Espanyol 1: Aduriz back with a bang|
|Metz 2 Paris Saint-Germain 3: Lavezzi late show sends Blanc´s men top|
|Four clubs face UEFA investigation regarding overdue payables|
|Icardi can reach the top at Inter, says Milito|
|Klopp open to Premier League interest|
|Marseille sweat on fitness of Gignac and Alessandrini|
|Mansfield part company with Cox|
|Pochettino calls for Tottenham unity|
|Alaba targets January return|
|Milan v Inter: Mancini returns for derby showdown|
|Zidane ban overturned|
|Hughes optimistic on Bardsley and Pieters fitness|
|No room for error against Malaga - Simeone|
|Crystal Palace v Liverpool: Six-goal thriller still fresh in the memory|
|Koeman hopeful on Schneiderlin fitness|
|Khedira or Isco will replace Modric - Ancelotti|
|Costa fully fit after hamstring problems|
|Rodgers rules out early Origi arrival|
|Garcia unsure of Castan timeframe|
|Hull City v Tottenham: Dawson returns as Bruce´s men seek response|
|Luis Enrique: No talks over Messi future|
|Schweinsteiger in line for Bayern return|
|Kompany and Lampard fit for City|
|A-League Review: Zadkovich sees red after just 17 seconds in Glory win|
|FA to investigate Whelan comments|
|Mourinho relishing busy schedule|
|Allegri reveals Lazio talks|
|Caen president steps aside following arrest|
|Moyes sees Everton similarities at Sociedad|
|Whelan not racist - Bruce|
|Balotelli: The goals will come at Liverpool|
|Torres wants to be Milan top scorer|
|Milito backs Martino to lead Argentina to success|
|Gonalons signs new Lyon contract|
|Spurs need to give Pochettino time - Dawson|
|Walcott out of United clash, Welbeck a doubt|
|Poyet targeting cover for Van Aanholt|
|Messi happy at Barcelona - Bartomeu|
|Pardew plays down Perez-Shearer comparisons|
|Werder Bremen suffer Di Santo blow ahead of derby|
|Everton will not rush Stones - Martinez|
|Monk: Swansea will not recall Michu|
|Colombian Primera A Review: Santa Fe, Medellin still perfect in semis|
|Brazilian Serie A Review: Cruzeiro rally to beat Gremio|
|Lallana: ´I´ve got friends´ at Southampton|
|Boca Juniors 0 River Plate 0: Honours even in Superclasico|
|Costa Rican Primera Division Review: Alonso scores 10th goal in Alajuelense win|
|Guarani 3 Cerro Porteno 4: Late Ortigoza goal lifts Astrada´s men to summit|
|Defensa y Justicia 1 Newell´s Old Boys 0: Pellegrino saves late penalty|