Matt Taylor will miss West Ham's Premier League clash with Aston Villa but James Tomkins is likely to be fit.
Taylor sustained a calf injury in the 2-0 League Cup victory at Burnley on Tuesday night and boss Sam Allardyce has revealed the midfielder will play no part against Villa on Saturday.
Tomkins also picked up an injury at Turf Moor, but is expected to be in contention to face Paul Lambert's side.
"From Tuesday Matt Taylor's definitely out; James Tomkins should be ok. The rest of the injured players won't be available which leaves us short of first-team squad players." said Allardyce.
West Ham have not won at home in the Premier League since recording a 2-0 triumph over Cardiff on the opening day of the season.
However, their recent results on the road have been encouraging, particularly a 3-0 win at Tottenham, and Allardyce believes the tide will soon turn.
He added: "We have to continue playing as we've been playing - (against) Swansea (where they drew 0-0), Tottenham away and even the home games when the results haven't gone our way.
"Goals have been hard to come by but we've got to be as resilient as we are away, come off with none conceded and I'm sure we would score a goal at home.
"Lots of teams are finding it tougher to secure points at home and it shows that tactically teams are going away and being strong.
"All that matters is winning football matches and getting points on the board in this league. Everybody said we've got to improve our away form. We've done that but now we've got to get our home form back to where it was last season.
"The players are bound to feel that little more anxious at home now but they've got to remember the good performances from before.
"We've got the worst chance conversion rate of anyone in the Premier League and that's the thing we've got to change."
|Coach: S. Allardyce|
|Tottenham job appeals to Sherwood|
|Sherwood gutted after defeat|
|Hughes: United worthy winners|
|Moyes pleased to see United weather storm|
|Allardyce hails West Ham fight|
|Coppa Italia: Juventus 3 Avellino 0|
|Manchester clubs kept apart in League Cup semi draw|
|League Cup: Tottenham 1 West Ham 2|
|League Cup: Stoke City 0 Manchester United 2|
|FIFA Club World Cup: Raja Casablanca 3 Atletico Mineiro 1|
|Sheffield Wednesday, Wigan abandoned due to heavy rain|
|United face anxious Rooney wait over injury|
|Messi making good progress|
|Ramos ban overturned|
|Osvaldo charged by FA|
|In-demand Ince offered new Blackpool deal|
|Molde confirm Solskjaer approaches|
|Kramer keen to continue home record|
|Rodgers: Henderson has potential to get even better|
|Ruiz on Anderlecht´s radar|
|Swansea, Hull fined by FA over player behaviour|
|Leeds keen on re-signing Gradel|
|Leverkusen announce Ryu deal|
|Ribery named Bundesliga Player of the Year|
|Moyes: No Zaha interest|
|Barcelona, Real Madrid in European Commission investigation|
|Basel: No Tottenham approach for Yakin|
|Chelsea set for Guarin bid, agent claims|
|Lewandowski has Dortmund goal concerns|
|Pogba, Pirlo will not sign before Christmas, says Marotta|
|Guardiola convinced to join Bayern after ´meat´ and greet|
|Martinez: Everton seen as a ´perfect´ loan destination|
|Anderlecht ´perfect´ for Defour, says Van Holsbeeck|
|Watford appoint Sannino|
|Sakho feels ´lucky´ to play with Suarez|
|Lippi: Too many teams competing in Club World Cup|
|Moyes ´told Welbeck to learn from Rooney´|
|I would kill myself over match-fixing, says Gattuso|
|Hughes dismisses calls for Januzaj protection|
|Aguero ´could miss up to two months´|
|Guardiola lauds Ballon d´Or nominee Ribery|
|Liverpool open Suarez contract talks|
|Copa del Rey Wrap: Barcelona, Levante cruise through|
|A-League Preview: Derby date beckons for winless Heart|
|Pearson upbeat despite Leicester defeat|
|Poyet urges Sunderland to build on Chelsea win|
|Mourinho rues missed chances|
|Pellegrini proud of professional Manchester City|
|Bayern on another level, says Beckenbauer|
|League Cup: Sunderland 2 Chelsea 1 (aet)|
|League Cup: Leicester City 1 Manchester City 3|
|FIFA Club World Cup: Guangzhou Evergrande 0 Bayern Munich 3|
|Zenit and Olympiacos punished with partial stadium closures|
|Sherwood wants positive reaction|
|Ancelotti expected La Liga title fight|
|Moffat charged over betting allegations|
|Wilson appointed at Barnsley|
|Wilshere charged by FA|
|Gattuso determined to clear his name|
|Moyes slams sacking culture|
|Mackay refuses to resign despite owner criticism|
|Redknapp reluctant to take Taarabt back|
|Amat pleased with development|
|Hughes optimistic of League Cup progression|
|Perez: No bids for Di Maria|
|FIFPro demand transfer system overhaul|
|Edwards sacked by Perth Glory|
|Allardyce not fearing the sack|
|Howson commits to Norwich|
|Tevez resigned to Argentina snub|
|SFA uphold Butcher´s one-match ban|
|Zapata rules out United switch|
|European Ombudsman calls for action on Spanish tax complaint|
|Albrighton eyes new Villa deal|
|Bale to miss Copa del Rey clash with ´small injury´|
|Pardew will bide his time in January|
|Kreuzer confident of Hamburg improvement|
|Van der Sar: Moyes can turn United around|
|Maradona backs Ronaldo for Ballon d´Or|
|Tottenham warned off Klinsmann|
|Costa Rica Primera Division: Alajuelense 0 Herediano 0|
|Lyon wary of Chornomorets Odesa|
|Guardiola talks up Lippi, Evergrande|
|Chile Primera Division Wrap: Chile, Deportes Iquique reach final|
|Garcia laments defensive mistakes|
|La Liga: Real Valladolid 3 Celta Vigo 0|