Auxerre caused the upset of the round as Sebastien Haller netted an extra-time winner to dump Ligue 1 Lille out of the Coupe de la Ligue.
The second-tier club had forced the game to an extra 30 minutes with a resolute defensive display away from home, but snatched a spot in the fourth round as Haller slipped the ball under goalkeeper Steeve Elana in the 23rd minute of extra time to seal a 1-0 victory.
It is the first time Lille, who missed out on last year's final after losing on penalties to St Etienne in the last four, have failed to make it beyond the third round since the 2008-09 season.
In another upset of sorts, top-flight basement club Valenciennes saw their miserable season continue as they lost 3-1 at home to Ligue 2 Troyes.
Yoann Court and Ghislain Gimbert gave the visitors a 2-0 lead at the break, and any hope provided by a Mathieu Dossevi strike after the break was soon dampened by a second for Gimbert.
At Stade de la Beaujoire, high-flying Nantes needed two second-half goals to see of Lorient.
Alejandro Bedoya put the hosts ahead in the 73rd minute, before Georges-Kevin N'Koudou added a second at the death to make sure of a fourth-round berth.
Bastia came away with a 1-0 victory from an all-Ligue 1 clash with Ajaccio in the early kick-off at Stade-Armand Cesari - Ilan scoring the only goal of the encounter in the seventh minute.
Rennes and Toulouse both picked up victories over lower-league opposition, as the former overcame Nancy 2-1 after extra time and the latter cruised to a 3-1 away victory over Creteil.
Elsewhere, the last remaining third-tier club in the competition - Amiens - fell to a 3-1 defeat at the hands of Ligue 2 second-placed club Tours, who now join Auxerre as the only non-top-flight sides still in the tournament.
The third round continues on Wednesday as Guingamp take on Evian, Montpellier head to Sochaux and Reims welcome Monaco.
|9||Túlio de Melo|
|Coach: R. Girard|
for D. Origi 73'
for J. Delaplace 88'
for Túlio de Melo 89'
|Stanislas brace leads Bournemouth past Yeovil|
|Watford slip to friendly defeat at Cardiff|
|Lukaku injury sours Everton win at Dundee|
|UEFA Champions League Review: Fenerbahce draw blank as Monaco impress|
|West Brom earn friendly win over Walsall|
|Vardy at the double as Leicester beat Burton|
|Atletico impress in win over Oviedo|
|Herrera sacked by Mexico after ´punch´|
|Gerrard, Keane and Bradley pull out of MLS All-Star squad|
|Marseille reach Diaby agreement|
|Sammer thrilled with Vidal´s winning mentality|
|Platini expected to launch FIFA presidency bid|
|Romanov sacked me over Barca snub - Korobochka|
|Villa complete Crespo capture|
|Wolfsberger v Borussia Dortmund: Bender praises ´fun but exhausting´ training|
|Okaka swaps Sampdoria for Anderlecht|
|Southampton v Vitesse: Fonte excited for ´dream´ sojourn into Europe|
|Bournemouth agree King compensation|
|West Ham v Astra: Kouyate confident West Ham can progress|
|Vidal completes Bayern switch, signs four-year deal|
|Fabregas calls for Champions League improvement|
|BREAKING NEWS: Filipe Luis completes Atletico return|
|Bayern to present Vidal|
|Wenger unfazed by Mourinho´s spending jibe|
|Pellegrini: Sterling will justify price tag|
|Cavani hit with two-match Uruguay ban|
|Bonucci to remain at Juve until 2020|
|No bids for Berahino - West Brom|
|Putin: Blatter deserves a Nobel prize|
|Howe: Swansea a benchmark for Bournemouth|
|New Parma to play in Serie D|
|Mata vows to hit the goal trail at United|
|Drogba ´perfect fit´ for Montreal|
|Berahino ´not yet´ ready for Tottenham - Irvine|
|Romero lauds caring Van Gaal|
|Jese flying at Real under Rafa|
|Sampdoria unwilling to pay €10m for Balotelli|
|Mourinho talks up Arsenal title chances|
|Hull sign Ryan Taylor, Sam Clucas|
|Kane, Pochettino hail MLS All-Star test|
|Di Santo sorry for swift Werder departure|
|Mourinho tells Ronaldo: Team honours come first|
|Khedira returns to Juve training|
|Celtic v Qarabag: Champions League return of utmost importance, says Collins|
|Pellegrini: Jovetic had to go|
|Manquillo completes Marseille move|
|Schalke reject Juve´s Draxler bid|
|Blanc: Di Maria deal ´close´|
|Di Santo debut ends in stalemate|
|Fire sign Drogba, trade him to Montreal Impact|
|FIFA and UEFA welcome ruling on third-party ownership|
|Juve kick off title defence against Udinese|
|Stoke sign free agent Afellay|
|Benitez confident Ramos will stay|
|Fenerbahce issue warning to fans|
|UEFA Champions League Preview: De Boer confident Ajax are ready for Vienna test|
|Bility: I am the favourite for FIFA presidency|
|Pienaar to miss start of season|
|Vietnam 1 Manchester City 8: Sterling shines as tourists run riot|
|All-Star Keane relishing Spurs clash|
|Shaun Wright-Phillips joins brother Bradley at Red Bulls|
|Inter 0 Real Madrid 3: Rodriguez stunner caps comfortable win|
|Villa sign Ayew|
|Watford complete Berghuis transfer|
|Robben returns to Bayern training|
|Pulis anxious to make West Brom additions|
|David Luiz eager to welcome ´fantastic´ Di Maria|
|Fernando injury free ahead of new campaign|
|Hummels blames weight issues for poor season|
|Defoe hoping for early Sunderland goals|
|Depay hints at identity of ´surprise´ United striker|
|Tigres UANL v River Plate: Hosts look to bounce back and make history|
|Crespo set for Villa move|
|Terry: I would never join a Premier League rival|
|Van Gaal coy on United future|
|Romero to cover potential De Gea exit - Van Gaal|
|Uruguay win men´s football gold at Pan Am Games|
|Pirlo thanks New York City fans for ´beautiful´ welcome|
|Mexico capitalised on ´the mistakes we made´ - Schafer|
|Herrera delighted with Mexico display|
|MLS Review: Whitecaps build happy home, Pirlo debuts|
|Guardado wins Golden Ball at Gold Cup|
|NZF confirms Olympics disqualification appeal|
|Jamaica 1 Mexico 3: CONCACAF giants complete form turnaround|
|New York Red Bulls 2 Benfica 1: Another scalp for MLS side|
|Romero signs with United|
|Moghreb Tetouan 1 Al Hilal Omdurman 1: Visitors go top|
|Van Gaal rules out Ronaldo bid|