Newcastle United and Manchester City head into their League Cup tie both in need of a quick response to disappointing results.
Alan Pardew's side slumped to a 2-1 defeat in their Premier League derby against Sunderland at the Stadium of Light on Sunday, a result that gave their fierce rivals their first league win of the season.
Mathieu Debuchy thought he had rescued a point for Newcastle when he cancelled out Steven Fletcher's early opener, but a superb late strike from substitute Fabio Borini handed Sunderland all three points in new manager Gus Poyet's first home game.
The defeat is typical of Newcastle's inconsistent start to the campaign, which has seen them win five and lose four of their 11 fixtures in all competitions.
One of those reverses came at City on the opening weekend of the Premier League season, when Manuel Pellegrini's men ran riot with a 4-0 victory.
Pardew has no fresh injury worries ahead of Wednesday's clash at St James' Park. Ryan Taylor (knee) remains a long-term absentee, while Fabricio Coloccini is unlikely to be risked as he continues his recovery from a groin injury.
Pellegrini, meanwhile, will also look to get his charges back on track after they fell to their third Premier League defeat of the season in a 2-1 defeat to fellow title hopefuls Chelsea on Sunday.
Sergio Aguero looked to have earned City a draw when he equalised Andre Schurrle's first-half opener, but a mix-up between Joe Hart and Matija Nastasic allowed Fernando Torres to tap home an injury-time winner.
The result leaves City in seventh place with 16 points from nine games, and Pellegrini will demand a response from his squad who have looked vulnerable defensively this season.
The Etihad Stadium outfit have scored more goals than anyone else in the top flight with 21 goals so far, but have also shipped 11.
Captain Vincent Kompany will be unavailable for the fixture as he continues his comeback from a thigh injury.
City hammered Wigan Athletic 5-0 in the round three of the League Cup, while Newcastle have defeated Morecambe and Leeds United to make it to this stage.
|Coach: A. Pardew|
for M. Haïdara 46'
for Shola Ameobi 67'
for P. Dummett 81'
|Ibrahimovic: United fans are waiting for me|
|Deulofeu shines for Everton, Cook opens Bournemouth account|
|Higuain out to emulate Del Piero|
|Kante does his talking on the pitch - Conte|
|Mourinho explains Fosu-Mensah snub|
|Klopp: No more unwanted players at Liverpool|
|Inter want more than €60m for Icardi - Thohir|
|Leicester can replace Kante - Ranieri|
|Lazio complete Wallace signing|
|Gueye set to join Everton, confirms Di Matteo|
|Tuchel: Transfer market has gone cash crazy|
|Leicester hand King new four-year deal|
|No deal done for Pogba, says Raiola|
|Rooney: Mourinho impact already huge|
|Lafferty hit with FA betting charge|
|Top-four finish never enough for Arsenal, insists Wenger|
|Partey hoping to make his mark on Atletico squad|
|Ibrahimovic in, Schweinsteiger out as United head for Galatasaray friendly|
|Vietto set for Sevilla after completing medical|
|I rejected Besiktas to fight for Barcelona spot, reveals Mathieu|
|De Laurentiis fumes at Higuain´s ´lack of respect´|
|Promising Janssen boosts Tottenham´s title hopes|
|Besiktas sign Adriano on three-year contract|
|Tottenham 0 Atletico Madrid 1: Godin grabs the winner|
|Gomis completes Marseille loan move|
|Iniesta surprised at Casillas-Del Bosque spat|
|New Juve signings do not guarantee success - Allegri|
|New Juve signings do not guarantee success - Allegri|
|Middlesbrough snap up goalkeeper Guzan|
|Guardiola still loves Ribery despite jibes|
|West Ham worry over Tore injury|
|Serie A could be another one-horse race, says Eriksson|
|Schweinsteiger retires from Germany duty|
|Iniesta welcomes Barca´s midfield competition|
|Drogba: No luck in Arsenal scoring record|
|Wenger seeks ´experienced´ striker to bolster Arsenal attack|
|Eriksson and Shanghai SIPG still fighting|
|MLS All-Stars 1 Arsenal 2: Premier League giants win late as Xhaka makes debut|
|Conte: I want aggression and intensity|
|Wimmer backs physical Janssen for Tottenham success|
|Klopp: I wouldn´t spend £100m on one player|
|Sampaoli: Taking Argentina job would be irresponsible|
|Payet absence no excuse - Noble|
|Gabriel Jesus expects Palmeiras exit amid Manchester City rumours|
|Domzale 2 West Ham 1: Crnic double stuns Bilic´s side|
|Juventus target Gabriel Barbosa says Santos exit is close|
|Leicester duo ready for ´once in a lifetime´ Champions League journey|
|Fabregas apologises for Klavan lunge|
|Reschke: Guardiola wanted Tuchel to be his successor|
|Pochettino expecting further Tottenham signings|
|Given retires from international football|
|Abdi and Pudil swap Watford for Wednesday|
|Leicester sign Chilwell to new five-year deal|
|Klopp pre-season ´most intense ever´ for Sturridge|
|Simeone backs Griezmann for Ballon d´Or final three|
|Puskas Award winner quits football - to become a gamer|
|Simeone: Champions League final felt like a death|
|Higuain: I have to prove my worth to Juventus|
|Guardiola confirms interest in Sane and Stones|
|Moreno set for Manchester City switch and Deportivo loan, claims agent|
|De Laurentiis pushed me into Juventus move - Higuain|
|Savic seeking to put injury woe behind him|
|Borussia Dortmund 1 Manchester City 1 (5-6 pens): Gunn´s shootout saves earn Guardiola first win|
|Oblak: Atleti need consistency and luck|
|Warburton rubbishes Van Persie rumours|
|Hospitalised Grujic ´can´t remember anything´, says Klopp|
|Premier League, Serie A appeal to Simeone|
|Copa Libertadores success ´a dream´ for Borja|
|Pochettino honoured by Simeone comparisons|
|Argentina have not asked for Sampaoli - Monchi|
|Ancelotti: Fitness the key for Bayern|
|Bayern win ´a small foundation´ for Montella´s Milan|
|Icardi missing due to injury - Mancini|
|Emery satisfied with warm-up win over Madrid|
|Conte quiet on Tevez, apologises for Fabregas red|
|´It was far from a friendly´ - Klopp on Chelsea defeat|
|Madrid off the pace, concedes Zidane|
|Chelsea 1 Liverpool 0: Cahill´s header seals win|
|Grujic says Chelsea´s Matic told him to sign for Liverpool|
|Bolasie wants to see Berahino and Benteke at Crystal Palace|
|Rodgers hails ´outstanding result´ as Celtic draw|
|Walcott claims level of MLS is close to Premier League|
|Bayern Munich 3 AC Milan 3 (3-5 on penalties): Bonaventura seals win|
|Atletico Nacional 1 Independiente del Valle 0 (2-1 agg): Borja secures Copa Libertadores crown|
|Icardi absent again as Inter held by Estudiantes|
|Real Madrid 1 Paris Saint-Germain 3: Zidane oversees poor pre-season start|
|Hazard vows to rediscover best Chelsea form|
|Klopp reveals why he sent Sakho back to Liverpool|
|Tevez: Conte wanted me at Chelsea|
|Sunderland hopeful Defoe will be fit for Man City opener|
|Sundowns overcome Zamalek to book semi-final spot|