Atletico Madrid aim to maintain their near-faultless start against Granada on Thursday hoping to capitalise on any slip-ups from Barcelona.
Diego Simeone's side are one point behind leaders Barca in the league table after the opening 10 matches and will be confident of keeping the pressure on at the top when they meet Granada, a team they have never lost to.
Celta Vigo – managed by former Barcelona player and coach Luis Enrique – come into their clash with the champions 48 hours before Atletico are in action brimming with confidence after a 5-0 victory over Malaga on Saturday.
It was only Celta's second win of the campaign and lifted them out of the bottom three, but they face the daunting task of trying to end Barcelona's unbeaten start to the season in all competitions.
Gerardo Martino's side notched their ninth league win of the campaign with a 2-1 Clasico victory over Real Madrid at the weekend and have not lost in Galicia on their last three visits.
Real will look to return to winning ways following the defeat at Camp Nou when they host Sevilla on Wednesday.
An upset looks unlikely as Real have only lost once at home in the league in 36 matches and Sevilla have not won at Santiago Bernabeu in the league since 2008.
However, Unai Emery's side travel to Madrid seven games unbeaten in all competitions, a run that was extended with a 2-1 success over Osasuna on Sunday.
Things are not as settled as Valencia after a second consecutive defeat in the league to Villarreal left Miroslav Djukic's men sit in mid-table. Djukic, though, will be confident of returning to winning ways when they face bottom club Almeria.
Almeria are yet to win in 2013-13 and are on a run of five defeats that sees them four points adrift at the foot of the table. To make matters worse, Almeria have not beaten Valencia in Liga action since January 2008.
Two sides that have started the season well – Villarreal and Getafe – meet at El Madrigal on Thursday with the hosts in buoyant mood following their 4-1 win over Valencia.
There will be a first meeting between Athletic Bilbao and Elche, while Espanyol and Malaga will look to put heavy weekend defeats behind them when they meet at Estadi Cornella-El Prat.
Strugglers Real Betis will hope to ease the pressure on head coach Pepe Mel with a first win in four matches when they face Levante.
Elsewhere, Real Valladolid and Real Sociedad meet on Wednesday after both sides recorded 3-0 victories at the weekend, while Osasuna take on Rayo Vallecano.
|Coach: Lucas Alcaraz|
for Y. Brahimi 61'
for Recio 67'
for M. Pereira 78'
|Portugal will be better than France - Santos|
|Kruse: I am 100 per cent fit|
|Mexico 3 Trinidad and Tobago 3: Herrera the hero for Ferretti´s men|
|FFA expect Tajikistan match to go ahead despite Dushanbe violence|
|Panama 0 Uruguay 1: Stuani´s late header clinches win|
|CONCACAF World Cup Qualifying Review: Jamaica stunned, Canada win|
|Argentina 7 Bolivia 0: Aguero, Messi star in rout|
|Canada 3 Belize 0: Hosts dominate in Toronto|
|Chelsea ´warehousing´ players - PFA chief|
|United States 2 Peru 1: Altidore inspires hosts´ comeback|
|Argentina 7-0 Bolivia: Aguero, Messi & Lavezzi net doubles in rout|
|Del Bosque unmoved by calls for two strikers|
|Deschamps praise for beautiful France|
|Fekir ruptures knee ligaments|
|Italy v Bulgaria: Conte warns against complacency|
|Euro 2016 Qualifiers Review: Germany top Group D, Northern Ireland edge closer|
|Low: Three points most important|
|Northern Ireland on the verge of a ´magnificent achievement´ - O´Neill|
|Scotland need something against Germany - Strachan|
|Portugal 0 France 1: Late Valbuena set-piece clinches deserved win|
|Faroe Islands 1 Northern Ireland 3: O´Neill´s men edge closer|
|Germany 3 Poland 1: Gotze sends world champions top|
|Gibraltar 0 Republic of Ireland 4: Irish hopes reignited|
|Djibouti 0 Togo 2: Saintfiet´s side make it two wins from two|
|Cyprus v Belgium: Benteke boost for Wilmots´ men|
|Roma youngster faces lengthy lay-off|
|United hit back at Perez barb over De Gea saga|
|Georgia 1 Scotland 0: Strachan´s men succumb to Tbilisi hoodoo|
|Hodgson prepared to blood new players|
|Porto invite Euro elite to help raise millions for migrants|
|Dortmund legend Dede backs Tuchel to succeed|
|Robben out for four weeks|
|Turkey v Netherlands: Terim expecting hostile atmosphere for crunch clash|
|Portugal 0-1 France: Valbuena strikes late to sink Ronaldo & Co|
|Wales v Israel: Euro 2016 beckons for Coleman´s history boys|
|Gala: No extra payment for Grosskreutz|
|Increase Bundesliga´s TV rights or be left behind - Rummenigge|
|Kane: I´m no flash in the pan|
|Perez: United showed inexperience in De Gea saga|
|Milligan: Socceroos wary of Tajikistan|
|Conte wants more players like Pelle|
|OFC World Cup Qualifying Review: Samoa to meet Tahiti in next round|
|Krychowiak stayed at Sevilla because of Emery|
|I never considered Bayern exit - Gotze|
|Balotelli ´not in good condition´, Milan must improve - Mihajlovic|
|Robben slams ´stupid´ Martins Indi|
|Robben laments injury blow|
|Euro 2016 Qualifiers Review: Bale edges Wales closer, Iceland dent Netherlands´ qualification hopes|
|De Bruyne relieved to ´boss´ Bosnia-Herzegovina|
|Blind furious after nightmare debut|
|Coleman sees shades of Charles in Bale winner|
|Conte only concerned about Italy winning|
|Mauritania v South Africa: SAFA to investigate Masilela no-show|
|AFC World Cup Qualifying Review: Qatar hit 15 in Bhutan rout|
|Belgium 3 Bosnia-Herzegovina 1: De Bruyne shines in straightforward victory|
|Cyprus 0 Wales 1: Bale winner takes Wales one step closer|
|Netherlands 0 Iceland 1: Sigurdsson winner caps difficult first game for Blind|
|Italy 1 Malta 0: Pelle spares wasteful Azzurri|
|Balotelli stars in Milan friendly win|
|Bhutan thrashed 15-0 by Qatar in qualifier|
|Rwanda v Ghana: Gyan doubt gives hosts hope|
|Tanzania v Nigeria: Enyeama out of AFCON qualifier|
|Valdes and Berahino included in Premier League squads|
|Costa Rica v Brazil: Dunga´s men return after Copa disappointment|
|Spain v Slovakia: Azpilicueta eyeing important revenge|
|Adebayor left out of Tottenham squad list for league and Europe|
|San Marino v England: Place in history books beckons for Rooney|
|Germany can cope with Reus absence - Low|
|Bayern offer aid to refugees in ´training camp´|
|BREAKING NEWS: Welbeck ruled out for months after knee surgery|
|South Korea 8 Laos 0: Son leads the way in rout|
|Australia 5 Bangladesh 0: Socceroos surge to emphatic win|
|Japan 3 Cambodia 0: Hosts pick up first qualifying win|
|Rudiger aiming to nail down Euros spot after Roma move|
|Melo happy to join Inter at last|
|Hernandez thanks Ferguson after United departure|
|Chung: AFC has compromised FIFA election|
|Wales the new best of British|
|Reus out of Germany qualifiers|
|Chile v Paraguay: Vidal missing for Copa champions|
|Ghedin: Anything is possible for Malta|
|Pogba will be worth €100m - Marotta|
|England can win Euro 2016 - Hodgson tells players|
|Conte unsure over Balotelli future|
|Argentina - Bolivia Preview: Mascherano backs 'very special' Messi|
|Portugal - France Preview: Deschamps aiming to correct mistakes|