Mikel Arteta scored a penalty before being controversially sent off as Arsenal heaped more misery on Crystal Palace with a 2-0 win.
The game marked Palace's first without Ian Holloway, who parted company with the club following Monday's 4-1 win defeat to Fulham.
Keith Millen took temporary charge for the encounter, and he will have been pleased with his side's showing as they competed well with the Premier League leaders.
However, it was Arsene Wenger's men who would claim the spoils when midfielder Arteta converted from the penalty spot after Adlene Guedioura's clumsy challenge on Serge Gnabry early in the second half.
Palace looked to have been handed a lifeline when the Spaniard was dismissed in the second half, adjudged to have denied Marouane Chamakh a clear goalscoring opportunity after hauling him down near the halfway line.
Goalkeeper Wojciech Szczesny preserved Arsenal's advantage in the dying stages with some fine saves, before Olivier Giroud headed home Aaron Ramsey's left-wing cross at the end of a quick counter-attack to finish things off.
Millen made six changes to the side beaten by Fulham, with Jerome Thomas, Barry Bannan and Chamakh among those to come into the side, while Mathieu Flamini and Santi Cazorla returned to Arsenal’s line-up in place of Jack Wilshere and Tomas Rosicky.
Arsenal created their first chance after just three minutes when Giroud headed Bacary Sagna's right-wing cross just over the crossbar.
The visitors were forced to change things inside the first 10 minutes, though, Flamini replaced by Gnabry after he limped off with an apparent groin injury.
Palace competed well for large periods of the first half, and had opportunities to take the lead themselves, Bannan heading over before Chamakh tested Szczesny with a long-range effort.
Both sides continued to trade chances in an open game, although Arsenal were aggrieved not to have been awarded a penalty as Chris Foy ruled that Damien Delaney's foul on Gnabry had been outside of the box.
But Foy did point to the spot when Gnabry was brought down by Guedioura less than two minutes into the second half, enabling Arteta to step up and fire home confidently from 12 yards.
Wenger's men began to dictate proceedings following the opener and should have doubled their advantage shortly after, Giroud missing the target from point-blank range after good work down the right from Sagna.
However, the game was completely changed after 65 minutes when goalscorer Arteta was shown a straight red card for pulling down Chamakh as the Moroccan attempted to break through on goal.
Palace immediately began to take charge following Arteta's dismissal, Szczesny performing heroics to tip Joel Ward's fierce effort onto the crossbar before producing another flying save to keep out Mile Jedinak's volley.
But Giroud wrapped things up three minutes from time to end the hosts' hopes of a late leveller.
for J. Thomas 57'
for A. Guédioura 71'
for B. Bannan 77'
|BREAKING NEWS: Fonte completes £8million West Ham switch|
|Morocco 3 Togo 1: Renard´s men back on track with comeback victory|
|BREAKING NEWS: Stoke complete £12million Berahino signing|
|Egypt v Uganda: Pressure on Pharaohs to kickstart campaign|
|Aspas responds to alleged Ramos spit|
|Stoke agree Berahino deal with West Brom|
|AC Milan complete Deulofeu loan signing|
|Gerrard returns to Liverpool as academy coach|
|Ivory Coast 2 DR Congo 2: Serey Die rescues point but holders still in trouble|
|Di Maria committed to PSG amid reported CSL interest|
|Sanchez a role model - Xhaka|
|Tuchel trusts Schurrle to fill Aubameyang void|
|Ghana v Mali: Rahman injury poses a problem for Grant|
|Depay not holding Manchester United grudge|
|I love watching them - Guardiola a huge fan of Pochettino and Tottenham|
|Klopp: I could kick Mane in the... lower back|
|Conte: Ake is ready to help Chelsea´s title bid|
|Allardyce provides Evra, Van Aanholt and Jenknson updates|
|Guardiola looks beyond beleaguered Bravo for City woes|
|Begovic could leave Chelsea - Conte|
|PSG still on the hunt for striker, says Emery|
|Mourinho: Valencia the best right-back in football|
|Mourinho on Young to China talk: He hasn´t told me anything!|
|Costa wants to stay at Chelsea, reveals Conte|
|´I played worse sometimes´ - Zidane defends Ronaldo from critics|
|Injured Iniesta to miss Eibar clash|
|Mourinho open to Depay return|
|Lyon confirm Depay arrival|
|Germany to bid for Euro 2024|
|Sydney FC 2 Adelaide United 0: Two goals in three minutes extend lead|
|Depay could face Marseille as Lyon boss Genesio hails winger´s ´big motivation´|
|Hull loan Elabdellaoui from Olympiacos|
|AC Milan make final offer for Deulofeu|
|Hughes ´wouldn´t encourage´ Bojan bids|
|Worker dies at World Cup stadium in Qatar|
|West Brom sign Livermore|
|Lyon president Aulas: Depay deal imminent|
|Aubameyang: I could leave Dortmund, but I´d never join Bayern|
|´Equating Messi with anyone else is like comparing a policeman with Batman´ - Sampaoli|
|It will take years to build football culture, Wenger warns CSL|
|´Worried´ Rakitic wants Barca renewal|
|Inter not signing Messi - Moratti|
|Luis Enrique hails Barca defence after ending Anoeta curse|
|´He is made of different stuff´ - Spalletti hails Nainggolan after wondergoal|
|Tottenham´s Janssen turned down Galatasaray move, agent claims|
|Did Carroll´s wondergoal give the West Ham striker whiplash?|
|Iniesta suffers calf injury|
|Swansea situation not ´hopeless´, says Clement|
|Real Sociedad 0 Barcelona 1: Neymar ends Anoeta curse|
|´Immeasurable bulls**t´ - Ligue 1 coach destroys Van Basten´s offside plan|
|Simeone praises Atletico´s precision in Copa Del Rey win|
|Fonte situation difficult for Southampton - Puel|
|´Some of the best football in the UK´ - Watford´s Mazzarri hails Bournemouth|
|Senegal 2 Zimbabwe 0: Cisse´s men charge into quarter-finals|
|Rivaldo backs Luis Enrique to deliver more Barca success|
|Atletico Madrid 3 Eibar 0: Routine win earns quarter-final lead|
|Jesus will make Premier League history - Rivaldo|
|Adebayor: Arsenal are just Ozil and Sanchez|
|Algeria 1 Tunisia 2: Favourites on brink of elimination|
|Bayern keen to seal Coman deal as Rummenigge cools Gnabry interest|
|Pochettino has done his homework on Jesus as Spurs look to march on|
|Scrap offside? Premier League managers give Van Basten´s plans a cool reception|
|Coman ready for Bayern comeback, confirms Ancelotti|
|Pochettino upbeat despite six weeks out for Vertonghen, Lamela still a mystery|
|Cerezo defiant over Griezmann amid talk of Manchester United agreement|
|Robinho named in Brazil squad for Chapecoense fundraiser|
|Davies and Lookman aren´t the big men of Everton, warns Koeman|
|Ivory Coast v DR Congo: Dussyer demands champions show true strength|
|Replacing Robben and Ribery not easy - Hitzfeld|
|Yeray back in Athletic training after successful cancer surgery|
|Karanka targeting more Boro deals after Bamford swoop|
|Cavani: I am the ultimate finisher|
|Morocco v Togo: El Ahmadi hungry for success|
|Ancelotti denies Verratti approach|
|A-League Review: Cahill double sees Melbourne City sink Mariners|
|Manchester United very happy with Shaw, insists agent|
|Mertesacker extends Arsenal deal|
|Boost for Arsenal as key quartet returns to training|
|Will Jesus save Manchester City´s title bid? Guardiola´s new striker in Opta numbers|
|Tevez mobbed after touching down in Shanghai|
|Payet exit not inevitable - Bilic|
|Wenger: Arsenal don´t need Payet|
|Jesus wants Manchester City titles|
|Orsolini arrives for Juventus medical|
|Rivaldo backs Coutinho to join Neymar at Barcelona|
|No danger of Messi leaving Barcelona, says father|
|Augusto: I convinced Oscar to come to China|
|Madrid-bound Maradona visits Napoli training|
|Sevilla in no rush over Sampaoli talks despite Barcelona links|
|Cafu: Resurgent Brazil can challenge world´s best|
|Klopp thrilled with Coutinho|
|Manchester United replace Real Madrid as world´s richest club|
|Madrid squad annoyed by defeats - Zidane wants more energy after latest loss|
|Casemiro rues more misery for Madrid against Celta|
|´Job done, let´s go home´ - Klopp happy to avoid extra time with narrow Plymouth win|
|FA Cup Review: Southampton leave it late to beat Norwich|
|Real Madrid 1 Celta Vigo 2: Aspas and Jonny extend Madrid winless run|
|Plymouth Argyle 0 Liverpool 1: Rare Lucas goal sees Klopp´s men through|
|Manchester City in La La Land as Schalke toil underground|
|Cameroon 2 Guinea-Bissau 1: Ngadeu-Ngadjui completes comeback to send Broos´ men top|
|Monaco confirm signing of Ajax teenager Antonucci|
|Manchester United´s interest in Griezmann is unsurprising - Simeone|
|Bamford ends spell in Chelsea wilderness with Boro return|
|Louis the great - Luis Enrique explains his and Barca´s debt to Van Gaal|
|Gabon 1 Burkina Faso 1: Spot-on Aubameyang makes his point|
|PSG send Ikone on loan to Montpellier|
|Senegal v Zimbabwe: Cisse wants to live up to favourites tag|
|Ghana´s Rahman leaves AFCON with knee injury|
|Algeria v Tunisia: Mahrez demands improvement in crucial Group B clash|
|Dortmund forward Dembele hits out at Bundesliga refereeing|
|Robben hopes Alonso stays at Bayern amid retirement rumours|
|Asian champions Jeonbuk banned from 2017 Champions League|
|Rakitic still an important player for Barcelona - Luis Enrique|
|Jesus will develop quicker at City - Emerson|
|Always take the weather with you - Spanish snow blights CSKA´s training camp|
|Messi never gave Coach interview, claims father|
|Gotze questions critics but admits to falling short of expecations|
|´Conte can have our title´ - Ranieri wants Chelsea to win the Premier League|
|Tottenham reject Premier League, Bundesliga offers for Wimmer|
|Liverpool sell Ilori to Reading|
|Potential victims in football abuse probe surpasses 500|
|Bonaventura signs new AC Milan contract|
|Messi: Ronaldo has achieved great things|
|Koscielny: Wenger has built men at Arsenal|
|Messi vows to stay at Barcelona ´for as long as they want me´|
|Cafu adamant Neymar will become world´s best|
|I´m just taking a sabbatical - Van Gaal denies he´s retired|
|Not even Gerrard won Premier League - Buttner says he´s not a United flop|
|Samper ignored Wenger as Barca midfielder rejected Arsenal|
|Pleased Pioli wants more from Inter|
|Evergrande boss Scolari dismisses Turan links|
|Klopp seeks legal advice over Matip|
|Marseille complete Sanson move|