Juventus face a tough ask in their bid to win their first UEFA Champions League match of the season when they travel to Real Madrid on Wednesday.
In a meeting of two of the true giants of European football, Juventus will be desperate for a win that would keep them in second position in Group B.
Juve have been held to 1-1 and 2-2 draws against FC Copenhagen and Galatasaray respectively and will enter the fixture off the back of a disappointing 4-2 loss at Fiorentina on Sunday.
First-half goals from Carlos Tevez and Paul Pogba looked to have Antonio Conte's side cruising, but Fiorentina – who were inspired by a hat-trick from Giuseppe Rossi – scored four times in the last 25 minutes to inflict Juve's first defeat of the season.
Conte hopes his side can respond quickly and denied claims that they were focusing on Real Madrid in the build-up to their trip to Florence.
"We lost a game that we dominated for 70 minutes. We were home and dry and had more than one opportunity to score the third goal," Conte said after the defeat.
"I don't think our focus was already on Real Madrid, otherwise we would have got our overall approach wrong."
Defender Stephan Lichtsteiner (thigh) and midfielder Simone Pepe (thigh) have been ruled out of the fixture.
And Juventus' injury worries do not stop there, with strikers Mirko Vucinic and Fabio Quagliarella (both thigh) also set to miss out.
Nine-time winners Real Madrid have won both of their Champions League fixtures this season, thrashing Galatasaray 6-1 before easing past FC Copenhagen 4-0.
Cristiano Ronaldo has scored five goals in those two matches, making him the competition's leading scorer.
The Portuguese star – who was top scorer last season with 12 goals – has now scored 24 goals in his last 20 Champions League appearances.
Ronaldo's 56 career strikes in the competition also see him fourth in the all-time scorers list.
World-record signing Gareth Bale has made just four appearances for Real since joining from Tottenham but returned from a thigh injury in the club's 2-0 win over Malaga on Saturday.
He is expected to feature against Juventus, while midfielder Xabi Alonso has returned to training following a broken foot.
The match will come too soon for Alonso but the news of his return will be a significant boost for Real, who can move a step closer to qualification for the Round of 16 with another victory.
|22||Á. di María|
|7||Cristiano Ronaldo||4' 29'|
|Coach: C. Ancelotti|
for K. Benzema 67'
for Illarramendi 72'
for Á. di María 79'
|Payet cleans up West Ham awards|
|´We don´t need superstars´ - Ranieri|
|Vidal: Bayern are still the best in the world|
|Guardiola: I have given my life to Bayern|
|Simeone: Atletico have eliminated two of the world´s three best teams|
|Leicester owner reveals Vardy signing doubts|
|Bayern feel cheated, says Rummenigge|
|Boateng: Bayern solely to blame for Champions League exit|
|Zabaleta confirms calf injury|
|´It was a siege´ - Torres proud of Atletico after holding off Bayern|
|Liverpool v Villarreal: Klopp demands improvement in Anfield return|
|Bayern Munich 2 Atletico Madrid 1 (2-2 agg): Griezmann clinches final berth with away goal|
|AFC Champions League Review: Victory, Al Hilal and Al Ain qualify with wins|
|Courtois ´100 per cent´ committed to Chelsea, denies PSG contact|
|Pellegrini: Madrid are more than Ronaldo|
|Trabzonspor handed four-game stadium ban|
|Morata muscle tear ruled out|
|Sevilla v Shakhtar Donetsk: Vitolo fired up to seal historic Europa League final spot|
|UEFA has opened Pandora´s box with Kosovo decision - Serbian FA president|
|Infantino claims positive response to FIFA funds plan|
|Aubameyang reiterates Real Madrid desire|
|Huth and Fellaini charged by FA|
|Cahill hopes for FA understanding after fiery Tottenham clash|
|Kehl slams Dortmund fans over Hummels boos|
|Mourinho congratulates Ranieri for winning ´my title´ with Leicester|
|Confusion reigns as City confirm Toure travels to Madrid|
|Mata: United can finish fourth and win FA Cup|
|Missing Champions League final would be a failure - Zidane|
|City without Toure for Real Madrid semi-final|
|Infantino hails Leicester title as ´the magic of football´|
|Redknapp talks up ´South Coast Mariners´ role|
|Real Madrid can cope without Benzema - Navas|
|Ronaldo returns for Madrid, but Benzema will miss Bernabeu clash|
|Ranieri wants happy players for title defence|
|Kosovo win vote to become UEFA member nation|
|Drinkwater: Leicester title is mad, bonkers|
|Morgan predicts tear-stained Premier League trophy|
|Transfer market travails and the empire striking back: What next for Leicester City?|
|Toure trains ahead of Real Madrid clash|
|Guardiola´s rotation policy a potential own goal - Magath|
|Ballack backs Atletico to prove too strong for Bayern|
|Messi agreed with Olympics snub - Martino|
|Benzema misses Real Madrid open training|
|Ranieri: We want to improve|
|Ronaldo: Like it or not, I´ll go down in history|
|Strootman delighted with return to Roma starting XI|
|Laporte dismisses Manchester City rumours|
|Ranieri has silenced critics, says Kisnorbo|
|Van Gaal: I am one of the best managers in the world|
|Santa Cruz: Guardiola will bring better football to City|
|Guardiola always a bit anxious - Kahn|
|Kisnorbo: No one will forget Leicester´s fairytale run to Premier League glory|
|Rodgers backs Klopp´s handling of Sturridge|
|Wright: No one would have touched Kante and Co.|
|Smalling: Captaining United an honour|
|No surprises in Mexico´s 40-man Copa squad|
|Juanfran: We are a team of details|
|Stepanenko: My friendship with Yarmolenko is over|
|Leicester fan Martinez: I am glad it did not happen in Germany|
|Schwarzer has shown age is just a number - Kisnorbo|
|Mangala: City want to make history in Champions League|
|Lineker struggling to believe Leicester success|
|Carrick: Top four not gone yet|
|De Gea named United´s player of the year|
|Dundee 2 Dundee United 1: Visitors relegated|
|King delighted to crown Leicester rise with title|
|Ranieri: I knew I would win a title eventually!|
|Soccer world reacts to Leicester´s remarkable Premier League title|
|Serie A Review: Strootman starts as Roma fight back again|
|Leicester success a ´good omen´ for Selby|
|Kane: Chelsea celebrated like they won title|
|Thumping Man City, edging Tottenham and five matches that won Leicester the Premier League|
|Vardy marvels at Leicester´s finest hour|
|Ranieri called me to say thanks, reveals Hiddink|
|Leicester did the impossible - Morgan|
|Terry: Leicester title triumph gives hope to smaller sides|
|Pochettino proud as Spurs fall short|
|Savage: Leicester title a key moment in Premier League history|
|Football world reacts to Leicester´s remarkable Premier League title|
|Leicester deserve Premier League title - Hazard|
|Leicester players celebrate Premier League title triumph in style|
|From Tinkerman to champion: Ranieri writes the greatest story ever told|
|Champions Leicester worthy of a film - Heskey|
|The greatest upset: Champions Leicester break new ground for sporting underdogs|
|Chelsea 2 Tottenham 2: Leicester champions as Spurs collapse at Stamford Bridge|
|Leicester crowned Premier League champions|
|Werder Bremen 6 Stuttgart 2: Crushing win lights up survival fight|
|Malaga 3 Levante 1: Late collapse all but relegates Rubi´s men|
|Neuer cites home crowd as advantage for Atleti clash|
|Icardi surprised by Argentina selection|
|Ribery fit to face Atletico in Champions League semi-final|
|FIFA extends Sakho ban worldwide|
|Torres and Atletico ready for war at Bayern|
|Football League Review: Burnley earn promotion back to the Premier League|
|Simeone pledges to chase victory at Allianz Arena|
|´Nothing in life is certain´ - Handanovic on Inter future|
|CAS order FIFA to reconsider Gibraltar membership|
|Trapattoni: I love Simeone and Atletico´s style|
|Balotelli is a changed man, says Galliani|
|Real Madrid job is about politics - Pellegrini|
|De Laurentiis wants Sarri at Napoli long term|
|Yarmolenko will not go to Everton or Stoke - Dynamo president|
|Suarez a difference maker - Stoichkov|
|Drinkwater to face no further action from FA|
|Albrighton: Leicester players will watch Chelsea v Tottenham together|
|More to Manchester City than Aguero - Casemiro|
|Boban: Maldini can save Milan|
|Real Madrid v Manchester City: Pellegrini eyes away goal as Zidane hopes for Ronaldo|
|Pellegrini doubts longevity of Leicester´s credentials|
|Portugal unconcerned by Ronaldo fitness|
|Ribery tells Guardiola to play him against Atletico|
|Vardy wins FWA Player of the Year award|
|Hiddink: Title pressure could get to Tottenham|
|Messi never cheats, insists Xavi|
|Dortmund tell Bayern Hummels fee is non-negotiable|
|Welbeck a different animal again - Wenger|
|Xavi: Real Madrid played like a small team in Clasico|
|Bayern can win Champions League - Santa Cruz|
|Reina backs Atletico to win the double|
|Perth Glory lure Herd to A-League|
|England can´t afford Australia loss - Kewell|
|Stankovic: Simeone will coach Inter, but not now|
|I had to rotate squad - Pellegrini|
|Candreva backs Inzaghi for Lazio job|
|I can make fans forget my bad season – Hazard|
|MLS Review: Cole sees red in Galaxy stalemate, Valeri stunner lifts Timbers|
|Pochettino: Deal announcement can convince Tottenham stars to stay|
|Hiddink: Chelsea can´t replace Terry|
|Pulisic, Morris picked by Klinsmann in initial Copa squad|
|Wenger anticipated worse from protests|
|Kante set to have stand named after him|