Manchester United aim to avoid back-to-back home defeats in the Premier League for the first time since 2002 when they welcome Southampton.
On that occasion United suffered 1-0 defeats to Middlesbrough and Arsenal respectively, as they relinquished their Premier League crown to Arsene Wenger's charges.
David Moyes' men were defeated 2-1 by West Bromwich Albion in their last home fixture on September 28, as strikes from Morgan Amalfitano and Saido Berahino sandwiched Wayne Rooney's equaliser.
But history is with United as Southampton have only taken one point from 14 Premier League visits to Old Trafford.
A 2-1 victory away to Sunderland before the international break got United back on track after consecutive top-flight losses to Manchester City and Albion.
That result leaves the champions in ninth spot with 10 points from seven games, and veteran midfielder Ryan Giggs - who has also taken on coaching responsibilities this season - insists there is plenty of time to recover from their slow start.
Speaking to The Manchester Evening News, the former Wales international said: "I am enjoying working with the new manager.
"Personally, I would prefer better results but we are only seven or eight games into the season."
Moyes will hope to have Rio Ferdinand (groin) available against Mauricio Pochettino's side, while Tom Cleverley remains a fitness worry after he withdrew from England duty due to a calf problem.
Adnan Januzaj will be hopeful of retaining his starting berth after a brace against Sunderland on his first Premier League start for the club.
Despite their poor record at Old Trafford, Pochettino will be buoyed by Southampton's excellent defensive record.
They have conceded just two goals in the Premier League so far in an impressive start to the campaign, and their defence has not been breached since a 1-0 setback away to Norwich in August.
The St Mary's outfit are on a three-game winning streak having seen off Liverpool at Anfield before home successes against Crystal Palace and Swansea City.
Southampton now have the chance to record back-to-back away victories in the top flight for the first time since September 2001.
Goalkeeper Artur Boruc missed Poland's 2-0 defeat against England at Wembley on Tuesday night with a hamstring injury but should be fit to feature, while Luke Shaw - who missed the Swansea game through illness - is also available for selection.
|20||R. van Persie||26'|
|Coach: D. Moyes|
for Nani 69'
for M. Fellaini 76'
for W. Rooney 87'
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