Spain qualified for the World Cup after beating Georgia 2-0 at Carlos Belmonte to finish top of Group I.
The world champions went into the match needing only a point to finish ahead of France, but they never looked like dropping points on their way to a comfortable win.
Georgia were under pressure for almost all of the match and substitute Juan Mata secured the win for Spain just after the hour mark, extending Del Bosque's unbeaten run in competitive home matches to 13.
The Spain coach made six changes from the narrow 2-1 win over Belarus on Friday, including returns for Iker Casillas and Andres Iniesta, while Alberto Moreno made his debut at left-back.
And the hosts dominated proceedings early on, with Negredo going close on two occasions in the first 25 minutes as he shot straight at the goalkeeper from close range and then saw his overhead kick tipped over the crossbar.
Negredo's persistence paid off eventually, however. Iniesta, playing in his home town of Albacete, got to the byline and played a low pass into the danger area which Negredo clipped home.
Georgia should have equalised a few minutes later as Casillas parried Tornike Okriashvili's shot into the path of Nikoloz Gelashvili, but the forward fired over the open goal.
Luck was on Georgia's side just before half-time when Negredo hit the post from close range, and Guram Kashia was there to clear his resulting header off the line.
Unsurprisingly, Spain's superiority continued into the second half, but they found the Georgia defence tougher to break down before eventually doubling their lead.
Aleksander Amisulashvili attempted to clear a cross from the left, but he headed the ball straight at Gerard Pique and Mata lashed the ball into the bottom corner, three minutes after coming on.
With 22 minutes to play, Iniesta would still have been hopeful of getting a goal of his own and he produced a good effort with his left foot that was deflected over.
Mata was also finding space and he nearly set Navas up in the 72nd minute with a low cross to the back post, but the Manchester City forward was crucially tackled at the vital moment.
And although the hosts pressed for more goals, ultimately they settled for a two-goal win as they booked their passage to the finals in Brazil next year.
|Coach: Del Bosque|
for Pedro 58'
for Xavi 66'
for Iniesta 82'
|Blanc could sign PSG renewal by end of week|
|PSG drawn against familiar foes Saint-Etienne in Coupe de France|
|Neville confident Valencia fans will be back|
|Guardiola praises beaten Bochum|
|Coupe de France Review: Ibrahimovic sends PSG through, Nantes win thriller|
|I love penalties - West Brom´s shootout hero Foster|
|Ross County 0 Hearts 3: Dauda dazzles in valuable victory|
|Bayern Munich avoid Borussia Dortmund in DFB-Pokal semi-finals|
|FC Heidenheim 2 Hertha Berlin 3: Ibisevic at the double in DFB-Pokal|
|Hart: We will fight for Pellegrini all the way|
|Peterborough United 1 West Brom 1 (aet, 3-4 on pens): Foster spares Premier League team´s blushes|
|Paris Saint-Germain 3 Lyon 0: Ibrahimovic fires holders into last eight|
|Valencia 1 Barcelona 1 (1-8 agg): Kaptoum breaks record with late leveller|
|Bochum 0 Bayern Munich 3: Lewandowski double helps book semi-final spot|
|Colour clash forces Stoke to produce new kit|
|Hernandez to miss Darmstadt match with muscle injury|
|Stoichkov backs ´smart guy´ Neymar to stay at Barcelona|
|FSG´s letter of apology to Liverpool fans in full|
|Huracan bus overturns following Copa Libertadores clash|
|Liverpool scrap ticket price increases following fan backlash|
|Oviedo hopeful of new Everton contract|
|Zoff: Juventus-Napoli a Scudetto match|
|Bolton chairman Phil Gartside dies aged 63|
|Palermo turn to Bosi after Barros Schelotto exit|
|Ben Arfa considered retirement from football during exile|
|Bilic: We paid the price for cup progress|
|Griezmann happy to stay at Atletico|
|Wales to face Sweden in final Euro 2016 warm-up|
|Varela hopeful of long United career|
|Ki: I had ice on my face for two days|
|Niasse settling in well, could face West Brom - Martinez|
|Stevens leaves Hoffenheim on health grounds and retires|
|Diaby nearing return after near 18-month lay-off|
|Nasri would love to finish career at Manchester City|
|Captain Howedes extends Schalke stay|
|M´Vila keen to stay if Sunderland survive|
|Johnson admits child sex and grooming charges|
|Amazing Mahrez is one of Premier League´s best - Ulloa|
|Ronaldo, Messi rivalry good for football - Zidane|
|Barros Schelotto leaves Palermo|
|Age is just a number - Ilori defends Klopp´s team selection|
|Messi, Suarez and Neymar rested for Copa second leg|
|Madrid can dream of trophies under Zidane - Raul|
|Ancelotti: Italy job is a decade away|
|Reus will become a monster, says Dortmund boss Tuchel|
|Young Tottenham stars don´t know their limits - Lloris|
|Niang happy at Milan despite Leicester interest|
|Ticket price rise means more tourist fans, warns football supporters chairman|
|Ogbonna revels in first West Ham goal|
|Copa Libertadores Review: Huracan, River Plate advance to group stages|
|Klopp backs Benteke to rediscover goalscoring form|
|Turan will not leave Barca for China - agent|
|Beating Chelsea more difficult without Mourinho - Motta|
|Tuchel praises Dortmund for ´perfect game´|
|Klopp rues Liverpool wastefulness in FA Cup loss|
|Allegri: Chelsea rumours unfounded|
|Bilic feels weight of history after Liverpool win|
|Coupe de France Review: Second tier Sochaux stun Ligue 1 Monaco|
|West Ham 2 Liverpool 1 (aet): Ogbonna sinks Klopp´s men in cup thriller|
|Football League Review: Rhodes rescues a point to send Boro top|
|Stuttgart 1 Borussia Dortmund 3: Aubameyang helps Tuchel´s men into last four|
|Kyle Allen blames chaotic Texas A&M culture on Johnny Manziel era|
|Dortmund fans stage protest against ticket prices for Stuttgart game|
|Bayer Leverkusen 1 Werder Bremen 3: 10-man hosts dumped out|
|Ferdinand fears title wilderness for United|
|Carvalho lands new Sporting deal with €45m buy-out clause|
|Ben Arfa out for at least four weeks with hamstring injury|
|Neville´s Valencia woes welcomed by Crespo|
|Ozil key to Arsenal´s title hopes - Rosicky|
|Zika threat could keep Solo from Rio Olympics|
|Blanc pleased to have solved David Luiz matter|
|Atletico midfielder Partey suffers thigh strain|
|Dickov: Leicester title run built to last|
|Guardiola not a menace for our players, says Luis Enrique|
|Mexico v Senegal: Osorio believes in youngsters|
|Celta Vigo v Sevilla: Krohn-Dehli not taking Copa del Rey final for granted|
|Madrid confirm Marcelo shoulder dislocation|
|Injury rules Chiellini out of crucial Juve games|
|Oblak extends Atletico deal|
|Blanc hints PSG could move for Ben Arfa|
|Luis Enrique urges Neymar to cope with off-field distractions|
|Carrick: Manchester United not throwing in towel|
|Neville determined to turn things around at Valencia|
|Guardiola hails Lewandowski professionalism amid Real Madrid and PSG rumours|
|Guardiola wary of ´aggressive´ Bochum|
|Premier League reveals new logo|
|West Ham open Payet contract talks|
|I could leave Barcelona for Guardiola, says Busquets|
|Giggs can be Manchester United´s Guardiola - Robson|
|Zidane has everything to become a great coach - Ancelotti|
|Carragher: Liverpool got it wrong on ticket prices|
|Neymar will be at Barcelona for years, claims director|
|Eder talks up Inter´s Scudetto chances|
|Larsson: Watching Barca is like playing FIFA|
|City recruit Wilkinson hoping to debut in Melbourne derby|
|Allegri will join Chelsea, says former coach|
|Zanetti: No need to compare Maradona and Messi|
|Vardy: I never expected Leicester to top Premier League|
|Capello: Ronaldo has at least three years at the top|
|Klopp hoping for Sturridge revival|
|Bilic wants new contract to keep Payet at West Ham|
|Shelvey can be as good as Cabaye - Sissoko|