Lowly Sao Paulo have ended Cruzeiro's unbeaten run, stunning the Brazil Serie A-leaders 2-0 thanks to two late goals.
Ademilson inspired Sao Paulo's victory at Cruzeiro's Estadio Governador Magalhaes Pinto, providing the final pass for both Douglas and Reinaldo's goals as the visitors snatched the three points away to the league leaders.
Cruzeiro had not lost in Brazil's top tier of football since August 14 but their 12-game unbeaten streak came to an end on Wednesday, as Sao Paulo notched consecutive wins to move out of the relegation zone.
Sao Paulo moved up to 16th with 33 points, one ahead of Vasco da Gama, who dropped into 17th, the highest position in Serie A's relegation zone, while Cruzeiro's gap at the top of the table remains 11 points after second-placed Gremio also lost.
In Belo Horizonte, Sao Paulo, who had overcome Vitoria 3-2 in the previous round, started strongly, testing Cruzeiro's goalkeeper Fabio from long range on a couple of occasions.
A sharp header from Cruzeiro midfielder Ricardo Goulart forced visiting goalkeeper Denis into a fine save soon after, while Willian wasted a huge opportunity for the hosts when he knocked a rebound into the post with an empty net beckoning.
Cruzeiro were denied a penalty early in the second half when Goulart appeared to be brought down by Rodrigo Caio before Paulo Ganso curled a free-kick just over the bar for Sao Paulo.
After plenty of end-to-end football, Sao Paulo finally broke the deadlock in the 77th minute when Ademilson turned sharply in the box to tee up the onrushing Douglas, who blasted the ball home.
Just three minutes later and it was 2-0 as Ademilson collected Ganso's deflected free-kick and cut the ball back for Reinaldo to head home from less than a metre.
Gremio missed the opportunity to take advantage of Cruzeiro's slip-up as they conceded an 89th-minute goal to lose 2-1 at home to Criciuma.
The visiting Criciuma side led at half-time through Wellington Paulista but Gremio looked to have salvaged a point after Maximiliano Rodriguez's 57th-minute equaliser, until Serginho scored with a minute left for the away team.
Botafogo took advantage of Gremio's loss and Atletico Paranaense's scoreless draw away to Corinthians by thumping Nautico 3-1 to move into third position.
Rafael Marques, Clarence Seedorf and Gege scored for Botafogo, who had to come from behind after Maikon Leite had given Nautico the home side the lead in the ninth minute.
In a poor round for the leading teams, fifth-placed Atletico Mineiro were stunned 2-0 by Ponte Preta and Bahia overcame sixth-placed Vitoria by the same margin.
In other results, Coritiba defeated Santos 1-0, Flamengo won 2-1 over Internacional, Vasco da Gama triumphed 1-0 against Fluminense and Goias held on for a 2-1 win against Portuguesa.
|Coach: Marcelo Oliveira|
for Ricardo Goulart 67'
for Egídio 73'
for Lucas Silva 86'
|Brnovic: Montenegro have no chance of qualifying|
|Russia had to resume after Akinfeev incident - Capello|
|Terim: Robben absence important|
|Morata keen to keep working|
|Canada 1 Guatemala 0: Haber heads Floro´s men to win|
|Difficult to find a place for Kane in starting XI - Hodgson|
|Difficult to find a place for Kane in starting XI - Hodgson|
|Montenegro-Russia abandoned after scuffle|
|Euro 2016 Qualifying Review: Montenegro-Russia abandoned, Spain and England win|
|Accrington Stanley 0 Newport County 2: Visitors up to sixth|
|Kane delighted with ´dream´ start|
|England 4 Lithuania 0: Kane enjoys dream debut|
|Spain 1 Ukraine 0: Morata settles tight contest|
|Akinfeev struck by flare as Montenegro-Russia game suspended after 30 seconds|
|Brazil v Chile: Winning is ´our only option´ - Dunga|
|Northern Ireland v Finland: Controversial fixture met with religious protests|
|Scotland v Gibraltar: Wilson out to dent countrymen´s hopes|
|Republic of Ireland v Poland: Pressure is on, says O´Neill|
|Georgia v Germany: Schneider warns world champions|
|PSV agree permament Guardado deal|
|France v Denmark: Olsen hits out at training facilities|
|Pienaar to return to Everton training|
|Hughes eyes silverware at Stoke after signing new deal|
|Portugal v Serbia: Carvalho vows to attack|
|Dynamo Kiev stadium partially closed after racism probe|
|Hull City fined £30,000 for misconduct|
|Balotelli must work hard for Italy return – Bonucci|
|Marchisio suffers knee ligament injury|
|Hughes agrees new Stoke City deal until 2018|
|Martinez hopeful over injured Everton trio|
|South Korea 1-1 Uzbekistan: Kuziboyev's debut strike denies hosts|
|South Korea 1 Uzbekistan 1: Kuziboyev´s debut strike denies hosts|
|Japan 2 Tunisia 0: Kagawa and Honda shine as Halilhodzic starts with a win|
|South Africa v Nigeria: Mashaba wary of bitter opponents|
|Japan 2-0 Tunisia: Kagawa & Honda shine in Halilhodzic's first game|
|Parma captain Lucarelli welcomes FIGC reforms|
|Di Francesco ignoring Milan rumours|
|Melbourne Victory 2 Central Coast Mariners 1: Finkler leads fightback|
|Bale would be ´perfect´ for United - Scholes|
|Badstuber and Bellarabi out of Georgia clash|
|Rooney KOs boxing celebration|
|Allen thrilled with Welsh ´hunger´|
|Kovacic to miss Euro 2016 qualifier|
|Costa Rica 0 Paraguay 0: Dour draw marks Diaz debut|
|Reid ruled out of South Korea friendly|
|Deschamps talks up France despite defeat|
|Rooney chasing England goalscoring record|
|Brazil ´superior´ admit French veterans|
|Reeves sidelined for Finland clash|
|Confidence critical for rampaging Brazil - Dunga|
|France 1 Brazil 3: Dunga´s men maintain winning run|
|Chile 0 Iran 2: Nekounam and Amiri down Copa America hosts|
|Premier League to share over £1bn from record TV deal|
|Morocco v Uruguay: Last chance to impress Tabarez for Copa champions|
|Iran 2-0 Chile: Nekounam and Amiri down Copa America hosts|
|Ivanovic braced for Ronaldo test|
|El Salvador - Argentina Preview: Messi set for Roca reunion|
|Bahrain 0 Colombia 6: Falcao stars in comfortable victory|
|Jones to Bournemouth leads loan deadline day moves in Championship|
|Bahrain 0-6 Colombia: Falcao stars in resounding victory|
|Malmo fined for poor pitch by UEFA|
|League Two Preview: Hartlepool aim to continue great escape, leaders Burton host Stevenage|
|France 1-3 Brazil: Neymar on target as Selecao triumph in Paris|
|Bulgaria v Italy: Verratti vows to be Azzurri´s midfield general|
|Kane primed for full England debut|
|Kone receives positive news over knee injury|
|Terry pens new Chelsea deal|
|PSG tie down Marquinhos|
|De Gea stamp was accidental - Skrtel|
|Villa hopeful over Xavi reunion|
|El Salvador v Argentina: Messi set for Roca reunion|
|Ghana v Senegal: Grant´s side looking to rebuild after AFCON disappointment|
|Ferdinand to serve extended touchline ban|
|League One Preview: Duo aiming to inspire Notts County revival, Alexander back at Preston|
|Hodgson keeps an eye on Sterling and Milner|
|Filipe Luis cools talk of Atleti return|
|West Brom to wear retro kit for Leicester clash|
|Netherlands v Turkey: Sneijder unconcerned by key absentees|
|Del Bosque wary of Ukraine threat|
|Israel v Wales: Pivotal fixture for both sides in chase for Euro dream|
|Bosnich backs Villa to beat drop|
|Walcott denies Wenger ´bust-up´|
|Hart: Aguero more difficult to face than Messi|
|Williams: I can´t see myself playing for anyone else|
|Coutinho eager to add more goals to his game|
|Khedira confirms Real exit|
|Messi attends NBA match with Argentina squad|
|United will qualify for Champions League - Bosnich|
|Mexico v Ecuador: Hernandez desperate to play|
|Podolski plays down Germany cameo|
|Bendtner: I could have scored four|
|Leverock family adds to World Cup exploits for Bermuda|
|Pele: ´Impossible´ for Neymar to replace me|
|MLS Preview: New England hoping to end drought|
|A-League Preview: Phoenix without stars for Sydney showdown|
|Klinsmann laments late collapse|
|Premier League clubs post first pre-tax profit for 15 years|
|Vokes relishing chance to link up with Bale|
|Dunga encourages Brazil to entertain|
|Dyke: FA to discuss Hodgson extension|
|Janko eyes history with Austria|
|Wilson urges Begovic to stay put|
|Strachan: Scotland have work to do|