Portugal face Israel in their penultimate World Cup qualifying game knowing defeat would almost certainly end their hopes of winning Group F.
Paulo Bento's side are one point behind Russia, but the pool leaders will be expected to take maximum points from their final two matches, against Luxembourg and Azerbaijan.
Victory over Israel in Lisbon on Friday would at least ensure Portugal finish no lower than second, so they could still progress through to the play-offs.
Captain Cristiano Ronaldo has called on his side to focus on their own job by defeating Israel before collecting a further three points when they face Luxembourg.
"I am confident in the victory," the Real Madrid superstar stated. "They are two games we have to win, we are the favourites and we will get on the field and give the best to ensure the six points.
"We just have to win both games and see what Russia does."
Ronaldo does not want to consider the possibility of Portugal - World Cup semi-finalists in 2006 - failing to qualify for Brazil 2014.
"All players play in big clubs and know the responsibility of playing in the national team. Missing two games and not winning is not worth thinking about," the attacker added.
"We have the better team and we need to show that on the field; we have a great chance to win the game."
Portugal have not lost a competitive match since October 2012 and host Israel, who sit five points back in third, having won their last three matches.
In contrast, Israel’s last victory came back in March and they were beaten by Russia last time out.
The previous group meeting between Portugal and Israel saw the former come from 3-1 down to snatch a draw through Fabio Coentrao’s late equaliser.
Coentrao is suspended on this occasion, along with Helder Postiga, while Bruno Alves, Joao Pereira, Miguel Lopes and Raul Meireles are all missing through injury.
Meireles' absence, due to a problem with his right thigh, was confirmed on Wednesday, with Custodio called up as a replacement.
Israel coach Eli Guttmann also has a squad blighted by injuries and has chosen to recall Barak Yitzhaki and Eden Ben Basat. Dudu Aouate retains his place, but there is no room for ex-captain Yossi Benayoun.
|Coach: Paulo Bento|
for Rúben Micael 69'
for Hugo Almeida 70'
for Miguel Veloso 87'
|Hull loan Elabdellaoui from Olympiacos|
|AC Milan make final offer for Deulofeu|
|Hughes ´wouldn´t encourage´ Bojan bids|
|Worker dies at World Cup stadium in Qatar|
|West Brom sign Livermore|
|Lyon president Aulas: Depay deal imminent|
|Aubameyang: I could leave Dortmund, but I´d never join Bayern|
|´Equating Messi with anyone else is like comparing a policeman with Batman´ - Sampaoli|
|It will take years to build football culture, Wenger warns CSL|
|´Worried´ Rakitic wants Barca renewal|
|Inter not signing Messi - Moratti|
|Luis Enrique hails Barca defence after ending Anoeta curse|
|´He is made of different stuff´ - Spalletti hails Nainggolan after wondergoal|
|Tottenham´s Janssen turned down Galatasaray move, agent claims|
|Did Carroll´s wondergoal give the West Ham striker whiplash?|
|Iniesta suffers calf injury|
|Swansea situation not ´hopeless´, says Clement|
|Real Sociedad 0 Barcelona 1: Neymar ends Anoeta curse|
|´Immeasurable bulls**t´ - Ligue 1 coach destroys Van Basten´s offside plan|
|Simeone praises Atletico´s precision in Copa Del Rey win|
|Fonte situation difficult for Southampton - Puel|
|´Some of the best football in the UK´ - Watford´s Mazzarri hails Bournemouth|
|Senegal 2 Zimbabwe 0: Cisse´s men charge into quarter-finals|
|Rivaldo backs Luis Enrique to deliver more Barca success|
|Atletico Madrid 3 Eibar 0: Routine win earns quarter-final lead|
|Jesus will make Premier League history - Rivaldo|
|Adebayor: Arsenal are just Ozil and Sanchez|
|Algeria 1 Tunisia 2: Favourites on brink of elimination|
|Bayern keen to seal Coman deal as Rummenigge cools Gnabry interest|
|Pochettino has done his homework on Jesus as Spurs look to march on|
|Scrap offside? Premier League managers give Van Basten´s plans a cool reception|
|Coman ready for Bayern comeback, confirms Ancelotti|
|Pochettino upbeat despite six weeks out for Vertonghen, Lamela still a mystery|
|Cerezo defiant over Griezmann amid talk of Manchester United agreement|
|Robinho named in Brazil squad for Chapecoense fundraiser|
|Davies and Lookman aren´t the big men of Everton, warns Koeman|
|Ivory Coast v DR Congo: Dussyer demands champions show true strength|
|Replacing Robben and Ribery not easy - Hitzfeld|
|Yeray back in Athletic training after successful cancer surgery|
|Karanka targeting more Boro deals after Bamford swoop|
|Cavani: I am the ultimate finisher|
|Morocco v Togo: El Ahmadi hungry for success|
|Ancelotti denies Verratti approach|
|A-League Review: Cahill double sees Melbourne City sink Mariners|
|Manchester United very happy with Shaw, insists agent|
|Mertesacker extends Arsenal deal|
|Boost for Arsenal as key quartet returns to training|
|Will Jesus save Manchester City´s title bid? Guardiola´s new striker in Opta numbers|
|Tevez mobbed after touching down in Shanghai|
|Payet exit not inevitable - Bilic|
|Wenger: Arsenal don´t need Payet|
|Jesus wants Manchester City titles|
|Orsolini arrives for Juventus medical|
|Rivaldo backs Coutinho to join Neymar at Barcelona|
|No danger of Messi leaving Barcelona, says father|
|Augusto: I convinced Oscar to come to China|
|Madrid-bound Maradona visits Napoli training|
|Sevilla in no rush over Sampaoli talks despite Barcelona links|
|Cafu: Resurgent Brazil can challenge world´s best|
|Klopp thrilled with Coutinho|
|Manchester United replace Real Madrid as world´s richest club|
|Madrid squad annoyed by defeats - Zidane wants more energy after latest loss|
|Casemiro rues more misery for Madrid against Celta|
|´Job done, let´s go home´ - Klopp happy to avoid extra time with narrow Plymouth win|
|FA Cup Review: Southampton leave it late to beat Norwich|
|Real Madrid 1 Celta Vigo 2: Aspas and Jonny extend Madrid winless run|
|Plymouth Argyle 0 Liverpool 1: Rare Lucas goal sees Klopp´s men through|
|Manchester City in La La Land as Schalke toil underground|
|Cameroon 2 Guinea-Bissau 1: Ngadeu-Ngadjui completes comeback to send Broos´ men top|
|Monaco confirm signing of Ajax teenager Antonucci|
|Manchester United´s interest in Griezmann is unsurprising - Simeone|
|Bamford ends spell in Chelsea wilderness with Boro return|
|Louis the great - Luis Enrique explains his and Barca´s debt to Van Gaal|
|Gabon 1 Burkina Faso 1: Spot-on Aubameyang makes his point|
|PSG send Ikone on loan to Montpellier|
|Senegal v Zimbabwe: Cisse wants to live up to favourites tag|
|Ghana´s Rahman leaves AFCON with knee injury|
|Algeria v Tunisia: Mahrez demands improvement in crucial Group B clash|
|Dortmund forward Dembele hits out at Bundesliga refereeing|
|Robben hopes Alonso stays at Bayern amid retirement rumours|
|Asian champions Jeonbuk banned from 2017 Champions League|
|Rakitic still an important player for Barcelona - Luis Enrique|
|Jesus will develop quicker at City - Emerson|
|Always take the weather with you - Spanish snow blights CSKA´s training camp|
|Messi never gave Coach interview, claims father|
|Gotze questions critics but admits to falling short of expecations|
|´Conte can have our title´ - Ranieri wants Chelsea to win the Premier League|
|Tottenham reject Premier League, Bundesliga offers for Wimmer|
|Liverpool sell Ilori to Reading|
|Potential victims in football abuse probe surpasses 500|
|Bonaventura signs new AC Milan contract|
|Messi: Ronaldo has achieved great things|
|Koscielny: Wenger has built men at Arsenal|
|Messi vows to stay at Barcelona ´for as long as they want me´|
|Cafu adamant Neymar will become world´s best|
|I´m just taking a sabbatical - Van Gaal denies he´s retired|
|Not even Gerrard won Premier League - Buttner says he´s not a United flop|
|Samper ignored Wenger as Barca midfielder rejected Arsenal|
|Pleased Pioli wants more from Inter|
|Evergrande boss Scolari dismisses Turan links|
|Klopp seeks legal advice over Matip|
|Marseille complete Sanson move|