The Ghana Football Association have written to FIFA asking for the second leg of their World Cup qualifying play-off with Egypt to be moved.
The clash on November 19 is scheduled to take place in Cairo, but the Ghanaian FA have raised concerns over the safety of playing the match in Egypt's capital.
Spectators have been banned from football stadiums in the city since February 2012 when more than 70 fans died during clashes between rival supporters, while two league seasons have been cancelled.
Al Ahly and Zamalek have been forced to move their CAF Champions League clashes away from Cairo in recent months due to safety concerns in the North African country.
The Ghana Football Association outlined their concerns to the world governing body in a letter published on their official website.
It read: "The Ghana Football Association (GFA) wishes to kindly request FIFA to move the venue for the 2014 World Cup Qualifying second-leg, play-off between Egypt and Ghana on 19th November, 2013 from Egypt to a safe and secure venue.
"Our request is premised on the alarming and fast deteriorating security situation in Egypt.
"The GFA is gravely concerned that for the past two years Egyptian authorities have only allowed football matches to be played without spectators yet Ghana has reportedly been asked to play Egypt in Cairo before fans.
"It is noteworthy that Egypt played all their home qualifying matches for the 2014 World Cup with Mozambique, Zimbabwe and Guinea in Egypt without spectators.
"Local clubs Al Ahly and Zamalek played their recent CAF Champions League matches behind closed doors as the security authorities refused the supporters access to the games because of the current turmoil in Egypt.
"Much as we sympathize with our brothers at the Egyptian Football Association, we are highly concerned about the security and safety of our players, officials and supporters and would like FIFA to take the necessary steps to protect lives from both Ghana and Egypt during the second-leg game."
The GFA have requested the game be played at a neutral venue, yet their Egyptian counterparts have insisted there is no reason for concern.
"The second leg match will be held in Cairo on November 19 and this is final. The security authorities will provide heavy security for the game," EFA spokesman Azmy Megahed told Ahram Online.
"These claims are unfounded and we reject all demands to play the game outside Egypt.
"We are capable of securing any game, not just the Ghana one. Ahly and Zamalek have been playing their games in the African Champions League in Egypt without any problems."
The nations play the first leg of their play-off on October 15 in Kumasi as they look to secure a place at Brazil 2014.
|MLS Preview: DC United, Orlando City battle for top spot|
|Panama 2 Costa Rica 1: Perez, Tejada end visitors´ unbeaten run|
|Kluivert´s Curacao advance to second round|
|Mexico 1 Paraguay 0: Eduardo Herrera´s debut goal secures victory|
|Mexico 1-0 Paraguay: Eduardo Herrera's debut goal secures victory|
|Argentina 2 Ecuador 1: Pastore the hero in Messi´s absence|
|Peru 0 Venezuela 1: Martinez goal settles heated contest|
|Wilmots pleased with Belgium´s response|
|Hodgson satisfied with draw|
|Argentina 2-1 Ecuador: Pastore the hero in Messi's absence|
|Real agree to sign Danilo|
|Turin return evoked ´strong emotions´ for Conte|
|Hiddink looking to build on Spain win|
|Del Bosque frustrated by friendly defeat|
|Bradford City 0 Chesterfield 1: Harrison strike moves visitors into play-off places|
|Portugal 0 Cape Verde 2: Hosts suffer shock friendly defeat|
|Townsend takes swipe at TV pundit Merson|
|Plane issue grounds England squad|
|Israel 0 Belgium 1: Fellaini nets again as Kompany sees red|
|N´Koulou returns to full Marseille training|
|Netherlands 2 Spain 0: Hosts ease pressure on Hiddink|
|Italy 1 England 1: Townsend leveller rescues draw|
|Ghana 1 Mali 1: Sako spot-kick denies Black Stars|
|Luxembourg 1 Turkey 2: Calhanoglu stakes claim with late winner|
|Ghana 1-1 Mali: Sako spot-kick denies Black Stars|
|Italy 1-1 England: Townsend rocket earns draw for Three Lions|
|Rummenigge marvels at ´genius´ Guardiola|
|Switzerland 1 United States 1: Stocker seals draw after Altidore red|
|Young players should not need a break, says Dyche|
|Tottenham acquire final piece of land for new stadium|
|Portugal 0-2 Cape Verde Islands: African minnows claim historic victory|
|Netherlands 2-0 Spain: Rejuvenated Dutch ease pressure on Hiddink|
|Switzerland 1-1 USA: Altidore sent off in friendly draw|
|Palestinian FA speaks out against Israel-Belgium venue selection|
|Valdes enjoying football again after injury nightmare|
|Emotional Cha retires ´a happy man´|
|Dortmund´s Kirch suffers knee injury|
|Newcastle need to be mentally prepared, says Williamson|
|Leno ´knows nothing´ of Real interest|
|Tunisia to compete in AFCON after apology|
|Van der Vaart not allowing future to affect his game|
|Vlaar: Sherwood has reduced stress levels|
|Roma hit by Gervinho hamstring blow|
|Jones optimistic over Everton´s strike partnership|
|Milik sustains knee ligament damage|
|Georgia fear stadium closure for Scotland clash|
|Zamparini: Juventus and Arsenal have bid for Dybala|
|South Korea 1 New Zealand 0: Lee nets late winner|
|Japan 5 Uzbekistan 1: Five-star hosts maintain Halilhodzic start|
|European clubs benefit from UEFA agreement|
|Vassell: Sky is the limit for Kane|
|Manchester United move would be an ´honour´ for Coentrao|
|Insigne out to bolster Napoli season after lay-off|
|Rooney warns Kane over ´clever´ Italy defenders|
|Rangers results reveal £500,000 Newcastle clause|
|Southampton announce £33.4m profit|
|´I am a very flexible man´ - Van Gaal|
|A-League Preview: Top spot up for grabs|
|Portugal - Cape Verde Preview: Andre and Oliveira eager for international bows|
|Puerto Rico 0 Canada 3: Floro´s men rout hosts|
|Xavi denies Al Sadd link|
|Fernando´s life ban upheld by CAS|
|Argentina - Ecuador Preview: Messi remains doubtful for friendly|
|Falcao equals Colombia´s all-time scoring record|
|Macedonia trip good learning curve - Postecoglou|
|Macedonia 0 Australia 0: Stalemate in Skopje|
|Del Bosque not out for Netherlands revenge|
|Burton Albion 1 Stevenage 1: Both teams score at wrong end in draw|
|Pekerman: I have no say on Falcao´s Manchester United future|
|Buffon has studied England new boy Kane|
|Conte urges patience from Italy fans|
|Johnson tasked with keeping Cheltenham up|
|Rooney not keen on Serie A switch|
|Kane to make first England start|
|Colombia 3 Kuwait 1: Spot-on Falcao equals Iguaran record|
|Goal-shy Barkley eyes striker´s role|
|UEFA opens disciplinary proceedings against Montenegro and Russia|
|Draxler and Choupo-Moting back in training|
|Ghana v Mali: Last chance to impress before Giresse return|
|Wilson: Gibraltar getting stronger|
|Mata confident of Spain future|
|Armenia coach Challandes resigns|
|Hiddink rubbishes talk of Dutch negativity|
|Portugal v Cape Verde: Santos set to rotate|
|Loren hails Moyes for Sociedad surge|
|Cruyff brands Netherlands ´a disgrace´|
|Kick It Out backs Barnes over race comments|
|Argentina v Ecuador: Messi remains doubtful for friendly|
|Coates backs Hughes ambition at Stoke|
|Atletico able to call on Saul again|
|Italy v England Preview: Kane set to start after dream debut|
|Zidane would accept Real job|
|Hernandez frustrated by lack of Real opportunities|
|Spartak donate money to 102-year-old fan after robbery|
|Clasie pulls out of Netherlands squad|
|Italy´s Bertolacci out of England friendly|
|Newcastle post record profit as Ashley debt stays the same|
|Al Sadd: We want Xavi to bring tiki-taka|
|Lacazette expected frosty Saint-Etienne reception|
|Barnes: I can´t get back into management because I´m black|
|Rooney praises England aggression|
|Southgate tips Kane for return to U21s|
|Mexico v Paraguay: Goals in order for Copa America aspirants|
|Netherlands - Spain Preview: Wijnaldum rallies behind under-fire Hiddink|
|Peru v Venezuela: Sanvicente wants Venezuelan response|
|Carvalho confident of playing Juventus|
|Neymar demands protection after Medel stamp|
|MLS Review: RSL, Fire secure breakthrough wins|
|Firmino firmly on radar - Dunga|