The Ghana Football Association have written to FIFA asking for the second leg of their World Cup qualifying play-off with Egypt to be moved.
The clash on November 19 is scheduled to take place in Cairo, but the Ghanaian FA have raised concerns over the safety of playing the match in Egypt's capital.
Spectators have been banned from football stadiums in the city since February 2012 when more than 70 fans died during clashes between rival supporters, while two league seasons have been cancelled.
Al Ahly and Zamalek have been forced to move their CAF Champions League clashes away from Cairo in recent months due to safety concerns in the North African country.
The Ghana Football Association outlined their concerns to the world governing body in a letter published on their official website.
It read: "The Ghana Football Association (GFA) wishes to kindly request FIFA to move the venue for the 2014 World Cup Qualifying second-leg, play-off between Egypt and Ghana on 19th November, 2013 from Egypt to a safe and secure venue.
"Our request is premised on the alarming and fast deteriorating security situation in Egypt.
"The GFA is gravely concerned that for the past two years Egyptian authorities have only allowed football matches to be played without spectators yet Ghana has reportedly been asked to play Egypt in Cairo before fans.
"It is noteworthy that Egypt played all their home qualifying matches for the 2014 World Cup with Mozambique, Zimbabwe and Guinea in Egypt without spectators.
"Local clubs Al Ahly and Zamalek played their recent CAF Champions League matches behind closed doors as the security authorities refused the supporters access to the games because of the current turmoil in Egypt.
"Much as we sympathize with our brothers at the Egyptian Football Association, we are highly concerned about the security and safety of our players, officials and supporters and would like FIFA to take the necessary steps to protect lives from both Ghana and Egypt during the second-leg game."
The GFA have requested the game be played at a neutral venue, yet their Egyptian counterparts have insisted there is no reason for concern.
"The second leg match will be held in Cairo on November 19 and this is final. The security authorities will provide heavy security for the game," EFA spokesman Azmy Megahed told Ahram Online.
"These claims are unfounded and we reject all demands to play the game outside Egypt.
"We are capable of securing any game, not just the Ghana one. Ahly and Zamalek have been playing their games in the African Champions League in Egypt without any problems."
The nations play the first leg of their play-off on October 15 in Kumasi as they look to secure a place at Brazil 2014.
|Messi vows to stay at Barcelona ´for as long as they want me´|
|Cafu adamant Neymar will become world´s best|
|I´m just taking a sabbatical - Van Gaal denies he´s retired|
|Not even Gerrard won Premier League - Buttner says he´s not a United flop|
|Samper ignored Wenger as Barca midfielder rejected Arsenal|
|Pleased Pioli wants more from Inter|
|Evergrande boss Scolari dismisses Turan links|
|Klopp seeks legal advice over Matip|
|Marseille complete Sanson move|
|Inter 3 Bologna 2: Candreva prevents remarkable turnaround in Coppa Italia thriller|
|FA Cup Review: Non-league Lincoln stun Ipswich, Burnley and Palace through|
|Gabon v Burkina Faso: Aubameyang says hosts have learned from Guinea-Bissau setback|
|Mali 0 Egypt 0: El-Hadary makes history in stalemate|
|El-Hadary oldest AFCON player ever - 44-year-old Egypt goalkeeper makes history|
|Reus and Gotze on target but Bender injured in Dortmund win|
|Toure shunning lavish China interest to stay at City, says Seluk|
|Rahman´s AFCON in the balance, says Ghana boss Grant|
|Just 14 goals conceded and nine clean sheets - How Vertonghen blow could impact Tottenham|
|Ghana 1 Uganda 0: Andre Ayew hands Black Stars nervy victory|
|Swansea snap up Carroll and Olsson in double swoop|
|All is forgiven? - Costa trains with full Chelsea squad after reported Conte bust-up|
|I would throw myself off a bridge for Luis Enrique - Rakitic dismisses Barca rift rumours|
|Was Juventus´ new logo inspired by tennis star?|
|Smooth sailing for Liverpool in Plymouth? Klopp expects tough test|
|Demichelis re-joins Malaga until end of season|
|Cameroon v Guinea-Bissau: Broos urges new heroes to emerge|
|Boxing champ hits Carragher with Chinese Super League comeback prank|
|Zidane backs Navas and defends Benzema as Madrid aim to bounce back|
|Deportivo bring in Kakuta from Hebei after CSL rule changes|
|Matip could miss eight games without doing anything wrong - Klopp|
|United trigger Valencia´s contract extension|
|Ronaldo returns to Real Madrid´s Copa squad|
|FA fine Sagna for Instagram post|
|Nedved does not foresee more January business for Juventus|
|Rafinha injury blow for Barcelona|
|Villas-Boas fumes at CSL foreign player crackdown|
|Ibrahimovic invaluable to Manchester United youngsters - Rashford|
|Robben rejected China move|
|A-League review: Phoenix rise to the occasion to end Victory´s streak|
|Van Gaal slams English media over treatment at Manchester United|
|Mignolet: Liverpool in better position to win title than in 2013-14|
|Giroud wants Premier League title but understands China temptations|
|Tianjin forced to scrap moves for Costa, Benzema, Cavani and Falcao|
|My goal was better than Mkhitaryan´s - Giroud|
|Pochettino not interested in Argentina job|
|Kane: Tottenham can win Premier League|
|Corinthians dreaming of Drogba - Paulo Roberto|
|Coutinho calls for Liverpool focus|
|Chiellini compares Pogba to LeBron and Bolt|
|Maradona to become Napoli ambassador|
|Mihajlovic furious after Torino collapse|
|Icardi has offers from China - Wanda Nara|
|Pogba can cope with pressure - Ibrahimovic|
|´My half-time words will stay in the dressing room´ - Montella annoyed with AC Milan|
|Juventus unveil dramatic change to club logo - but not everyone´s a fan|
|´I do not think I will return to coaching´ - Van Gaal set to call it quits|
|Torino 2 AC Milan 2: Bacca caps thrilling comeback as hosts pay the penalty|
|DR Congo 1 Morocco 0: Kabananga pounces on blunder to give 10 men the points|
|´Happy and comfortable´ Sanchez dismisses Arsenal exit talk|
|How much?! West Ham flop Simone Zaza could cost Valencia €20m|
|Mali v Egypt: Salah leads Pharaohs´ bid for AFCON glory|
|Sevilla concede they ´cannot force´ sporting director Monchi to stay|
|Ivory Coast 0 Togo 0: Reigning champions held to opening draw by Adebayor and co.|
|Goalkeeping woes, Stones and tactical confusion - How Guardiola is making life difficult for himself|
|Ozil and Sanchez can be persuaded to stay - Cech|
|Pogba: I rejected Barcelona and Real Madrid|
|Ghana v Uganda: Gyan dreams of first trophy since 1982|
|Chiellini: Juventus a work in progress|
|Robben agrees Bayern renewal until 2018|
|Hazard: Goals do not matter to me|
|Bennell pleads not guilty to eight child sex offences|
|Muller fed up with debate over Bayern role|
|Wenger glad Sanchez is not ´a Costa problem´|
|Flick resigns as DFB´s sporting director|
|Gomis ´can´t wait´ to welcome Payet to Marseille|
|Chinese FA changes foreign player rules after ´irrational´ spending|
|Like father, like son: Justin Kluivert follows in dad´s footsteps|
|´No reason to lose him´ - Marotta rubbishes talk of Allegri exit|
|Courtois: We don´t need Costa|
|Kane: Tottenham players won´t go to China|
|Noble ´angry and disappointed´ with Payet|
|Klopp furious over Matip uncertainty|
|Wenger surprised by tight Premier League|
|´Money is not everything´ - Conte issues warning amid China speculation|
|Fiorentina defeat a ´bad setback´ - Allegri|
|´This will elevate this group of players´ - Sampaoli revels in Sevilla late show|