The Ghana Football Association have written to FIFA asking for the second leg of their World Cup qualifying play-off with Egypt to be moved.
The clash on November 19 is scheduled to take place in Cairo, but the Ghanaian FA have raised concerns over the safety of playing the match in Egypt's capital.
Spectators have been banned from football stadiums in the city since February 2012 when more than 70 fans died during clashes between rival supporters, while two league seasons have been cancelled.
Al Ahly and Zamalek have been forced to move their CAF Champions League clashes away from Cairo in recent months due to safety concerns in the North African country.
The Ghana Football Association outlined their concerns to the world governing body in a letter published on their official website.
It read: "The Ghana Football Association (GFA) wishes to kindly request FIFA to move the venue for the 2014 World Cup Qualifying second-leg, play-off between Egypt and Ghana on 19th November, 2013 from Egypt to a safe and secure venue.
"Our request is premised on the alarming and fast deteriorating security situation in Egypt.
"The GFA is gravely concerned that for the past two years Egyptian authorities have only allowed football matches to be played without spectators yet Ghana has reportedly been asked to play Egypt in Cairo before fans.
"It is noteworthy that Egypt played all their home qualifying matches for the 2014 World Cup with Mozambique, Zimbabwe and Guinea in Egypt without spectators.
"Local clubs Al Ahly and Zamalek played their recent CAF Champions League matches behind closed doors as the security authorities refused the supporters access to the games because of the current turmoil in Egypt.
"Much as we sympathize with our brothers at the Egyptian Football Association, we are highly concerned about the security and safety of our players, officials and supporters and would like FIFA to take the necessary steps to protect lives from both Ghana and Egypt during the second-leg game."
The GFA have requested the game be played at a neutral venue, yet their Egyptian counterparts have insisted there is no reason for concern.
"The second leg match will be held in Cairo on November 19 and this is final. The security authorities will provide heavy security for the game," EFA spokesman Azmy Megahed told Ahram Online.
"These claims are unfounded and we reject all demands to play the game outside Egypt.
"We are capable of securing any game, not just the Ghana one. Ahly and Zamalek have been playing their games in the African Champions League in Egypt without any problems."
The nations play the first leg of their play-off on October 15 in Kumasi as they look to secure a place at Brazil 2014.
|MLS Review: Sounders a step closer to final, Crew and Toronto in stalemate|
|Ben Yedder trolls Liverpool after dramatic Sevilla comeback|
|´World class´ Insigne can´t be rested – Sarri|
|I say one thing and you write something else - Angry Ronaldo brushes off media|
|Griezmann needs support of Atletico and fans – Simeone|
|Monaco paid for mistakes in Champions League exit - Jardim|
|We had to rely on personal pride - Berizzo praises Sevilla´s stunning comeback|
|Championship Review: Coleman loses first Sunderland game, Fulham win nine-goal thriller|
|City fans get first sight of local star they crave in Phil Foden|
|Gunes wants more after historic Besiktas Champions League qualification|
|Allegri plays down Dybala-Messi comparisons|
|Extra rest helped Rose shine in Dortmund – Pochettino|
|Zidane: We knew Ronaldo, Benzema goals would come|
|It feels like we lost - Klopp frustrated at Liverpool´s second-half collapse|
|It depends on Foden - Guardiola puts ball in teenager´s court|
|Postecoglou leaves Australia post|
|Ronaldo overtakes Messi in Champions League goalscoring race|
|Manchester City 1 Feyenoord 0: Sterling strikes late as top spot is clinched|
|Sevilla 3 Liverpool 3: Klopp´s side fail to survive Spanish inquisition|
|Borussia Dortmund 1 Tottenham 2: Son grabs winner as Spurs seal top spot|
|Napoli 3 Shakhtar Donetsk 0: Insigne stunner helps keep knockout hopes alive|
|APOEL 0 Real Madrid 6: Record-breaking Ronaldo and Benzema send holders through in style|
|Monaco 1 RB Leipzig 4: Werner brace dumps Ligue 1 champions out|
|Ronaldo breaks record for Champions League goals in a calendar year|
|I wanted to cry with Buffon - Rakitic sympathy for Italy great|
|Defiant Smalling responds to ´surprise´ England omission|
|Neuer ´on schedule´ but Heynckes won´t rush Bayern star|
|Messi contract saga not swaying Barcelona boss Valverde|
|Spartak Moscow 1 Maribor 1: Stoppage-time equaliser gives Russians everything to do at Anfield|
|Besiktas 1 Porto 1: Talisca leveller sends hosts through|
|Mkhitaryan questions leave Mourinho riled|
|Jones out of Basel, Brighton games but Mourinho hopeful on Bailly|
|Conte unhappy with Chelsea´s fixture congestion|
|Pepe tells Ronaldo: Come to Besiktas!|
|Clement expects Abraham to shake off back injury for Bournemouth clash|
|Oddo replaces sacked Del Neri at Udinese|
|Bartomeu hints at January Barcelona signings|
|Emery defends ´responsible´ Neymar from lifestyle criticism|
|Del Neri sacked by Udinese|
|Everton striker Niasse facing two-match ban after FA diving charge|
|Lampard excited by English clubs in Champions League|
|Thiago and Coman back for Bayern´s trip to Anderlecht|
|Dybala hails Messi as ´our Maradona´, wants to play with Neymar|
|Sherwood talks up Spurs as potential Champions League winners|
|Borussia Dortmund on the brink as Real Madrid eye progress - Champions League in Opta numbers|
|Hughton hopeful on video assistance after Brighton denied penalty|
|Klopp staying calm over Salah form|
|Griezmann: I don´t regret staying at Atletico|
|Guardiola dismisses Champions League favourites tag|
|Brighton and Hove Albion 2 Stoke City 2: Gross, Izquierdo extend home unbeaten run|
|Rose in contention to face Dortmund as Pochettino denies ´issue´ with defender|
|Benzema knows he can give more – Zidane|
|I´ve fulfilled my dreams already – Klopp has no plans to coach Barcelona|
|Aubameyang will face Tottenham, Bosz confirms|
|Klopp expects Matip to face Chelsea, Lallana return getting ´nearer´|
|Berizzo looking to former Red Aspas to provide lessons for Sevilla|
|Mangala ready to pounce, but realistic on Man City playing time|
|Mendy injury means Aguero or Jesus for Guardiola|
|Guardiola sends ´big hug´ to ´amazing, so gentle´ Pulis|
|Tavecchio quits as head of FIGC, claims board have refused to resign|
|Benedetto facing Argentina World Cup KO with cruciate injury|
|Shape up! Heynckes reveals demand to Bayern star Vidal|
|Ramos sits out Madrid trip to APOEL|
|West Brom sack Pulis after wretched run|
|Lloris wants Spurs to forget title and focus on top four|
|Pogba no Gerrard yet, says Benitez|
|Guardiola will ´kill´ City stars if they get complacent|
|Ibrahimovic: My injury was worse than people know|
|Icardi like a ´raptor pouncing on its prey´, says Spalletti|