Tottenham will look to extend their unbeaten home record when they welcome struggling West Ham on Sunday.
Andre Villas-Boas' side are undefeated in their last 10 competitive matches at White Hart Lane, last tasting defeat at the venue against Fulham in March.
Home Premier League wins against Swansea City and Norwich City have seen Tottenham's campaign begin positively and they lie third in the table, behind only Liverpool and London rivals Arsenal.
Spurs will enter the game off the back of a 2-0 UEFA Europa League win at Anzhi Makhachkala on Thursday, with Jermain Defoe and Nacer Chadli scoring in the first half for the visitors.
Defoe has now scored seven goals in cup matches for Tottenham this season, but he has netted just once in the league this year.
The 30-year-old will be out to change that if he starts against his old club, but Spaniard Roberto Soldado is likely to be preferred up front by Villas-Boas.
The Portuguese manager will be without defender Younes Kaboul after he picked up a knock in Russia, while Danny Rose (toe), Aaron Lennon (foot), Etienne Capoue (ankle) will also miss out, and Emmanuel Adebayor is doubtful.
In stark contrast to Tottenham, West Ham have struggled this season, and with just one win from their six Premier League matches, they lie 17th in the table.
Their difficulties have hinged largely on failure to score regularly and their goals tally is the joint lowest in the top flight.
The absence of high-profile signing Andy Carroll (heel) has hurt manager Sam Allardyce, with not one striker having scored for the club in the current campaign.
They have been sharp defensively, though, conceding just five league goals, but will be wary of a dreadful away record in the Premier League.
West Ham, who will welcome midfielder Joe Cole back from a hamstring injury, have won just one of their last 17 road trips in the league.
George McCartney (knee) could also feature in a match that Allardyce is keen to assume the underdogs tag for.
"If you spend £100 million, as Spurs have, you'd expect Andre Villas-Boas to have to live with that pressure in getting that team to play to its capabilities as quickly as possible," he said.
"It doesn't always click immediately, but he must be delighted with how it's going so far. They've moulded into a team quickly, which is a big bonus for him and Tottenham."
Tottenham will also enter the match with history on their side, having won nine of the last 12 encounters between the two clubs, with two ending in draws.
West Ham's only win against Tottenham since May 2006 came when Frederic Piquionne's first-half strike gave them a 1-0 success at Upton Park in 2010.
|Coach: André Villas-Boas|
for G. Sigurdsson 63'
for C. Eriksen 73'
for K. Naughton 80'
|´Anger and disappointment´ in PSV dressing room|
|QPR reveal new stadium plans|
|Petkovic: Lazio criticism warranted|
|Laudrup hails Swansea´s European achievement|
|Soldado confidence will soar, says Villas-Boas|
|Guingamp can test Monaco with speed, says Ranieri|
|UEFA plan to prioritise match-fixing problem|
|UEFA Europa League Wrap: PSV crash out, Tottenham run riot|
|UEFA Europa League: Tottenham 4 Anzhi Makhachkala 1|
|Bayern to face MLS All-Stars|
|Gerrard out for at least four weeks|
|UEFA Europa League: Maribor 2 Wigan Athletic 1|
|UEFA Europa League: St Gallen 1 Swansea City 0|
|Klinsmann extends USA deal|
|La Liga Preview: Osasuna v Real Madrid|
|FA to consult Hull fans over name change|
|Premier League Preview: Newcastle United v Southampton|
|West Brom wait on Anichebe illness update|
|Serie A Preview: Juventus v Sassuolo|
|Pulis plays down reports of Rhodes raid|
|Bundesliga Preview: Hoffenheim v Borussia Dortmund|
|Meulensteen pleased with Fulham progress|
|Premier League Preview: Everton v Fulham|
|Bassong signs new Norwich deal|
|Dutt confident of Werder response|
|La Liga Preview: Barcelona v Villarreal|
|Pochettino proud of Southampton character|
|Zanetti urges Inter to make Lavezzi move|
|Anigo refuses to rule out Marseille extension|
|Hughes wants Stoke momentum|
|Premier League Preview: Chelsea v Crystal Palace|
|Bundesliga is the best, says Ribery|
|Olsen pens new Denmark deal|
|Premier League Preview: West Ham v Sunderland|
|Howedes and Draxler out until new year|
|Sakho targeting Europe return with Liverpool|
|Bundesliga Preview: Bayern Munich v Hamburg|
|Vorm to undergo knee surgery|
|Mkhitaryan lauds Dortmund spirit|
|Young unconcerned by ´diver´ tag|
|Higuain gutted after ´injustice´|
|Berlusconi blasts ´deliquents´ after violence|
|Premier League Preview: Manchester City v Arsenal|
|Poyet calls for Sunderland patience|
|Neymar happy after hat-trick|
|Martinez hails ´special´ Deulofeu|
|Mourinho wants ´King Didier´ reunion|
|Villas-Boas aims for perfect Europa League record|
|De Boer: Milan unworthy of last-16 spot|
|Colombia Primera A: Deportivo Cali 0 Atletico Nacional 0|
|FIFA Club World Cup Preview: Monterrey v Raja Casablanca|
|Fonseca berates Porto defence|
|Copa Sudamericana: Lanus 2 Ponte Preta 0 (3-1 agg)|
|Klopp blasts wasteful Dortmund despite win|
|Yakin rues Ivanov red card, Basel´s Euro exit|
|Atletico ´hungry´ for success, says Garcia|
|Allegri relieved as Milan progress|
|Martino lauds ´amazing´ Neymar|
|De Laurentiis: Napoli will take Europa League seriously|
|Lennon slams ´weak´ Celtic|
|Wenger feels for eliminated Napoli|
|Matip: Win was for coach Keller|
|Marseille should not be ashamed, says Anigo|
|Ligue 1 Preview: Anigo eyes Marseille revival, Monaco target PSG|
|Chelsea always in control, says Mourinho|
|UEFA Champions League: Marseille 1 Borussia Dortmund 2|
|UEFA Champions League: Barcelona 6 Celtic 1|
|UEFA Champions League: Milan 0 Ajax 0|
|UEFA Champions League: Austria Vienna 4 Zenit St Petersburg 1|
|FIFA Club World Cup: Raja Casablanca 2 Auckland City 1|
|UEFA Champions League: Napoli 2 Arsenal 0|
|UEFA Champions League: Atletico Madrid 2 Porto 0|
|Schwarzer makes Champions League history|
|Kisenkov handed six-match spitting suspension|
|Bruce happy with Sagbo impact|
|Valencia eager to attract investment|
|Roux not focused on World Cup selection|
|Corinthians name Menezes as new coach|
|Too early for top-four talk, insists Cabaye|
|Tottenham to fast-track Vertonghen recovery|
|Beaten Conte critical of conditions|
|Ibrahimovic hails PSG youngsters|
|Honda to join Milan in January|
|Giaccherini happy at Sunderland, says agent|
|UEFA Champions League: Galatasaray 1 Juventus 0|
|Baines eyes festive return|
|Boateng extends Bayern deal|
|Pieters tips De Jong for Stoke|
|Arrasate talks up Champions League impact|
|Spalletti expects Vienna test|
|Juventus ´not interested´ in Kolarov|
|Fonseca calls for Porto balance|
|Dalglish backs Suarez to shine on world stage|
|Brunt: West Brom are no Mickey Mouse club|
|Klopp unsure over Marseille sacking effect|
|Howson in ´best form´|
|Ronaldo grounded despite record haul|
|Liverpool´s Kelly fighting fit|
|Guardiola calm over Champions League defeat|
|Bony boost for Swansea|
|A-League Preview: Mariners eye perfect 10 against Reds|
|Lucescu laments Donetsk performance|
|Michel: Olympiacos deserved knockout-stage spot|
|Pellegrini displays Munich confusion|
|Delaney credits Copenhagen second-half display|
|Sociedad president learns lessons from exit|
|Jesus believes Benfica deserved to progress|
|Vrba delighted with ´amazing´ Moscow win|
|Hyypia hails Leverkusen belief|
|Second-half show disappoints Blanc|
|UEFA Europa League Preview: Maribor v Wigan Athletic|
|Moyes eyes UEFA Champions League glory|
|Lahm takes positive from City loss|