Roma will look to extend their 100 per cent Serie A record when Rudi Garcia's side take on Inter in a mouth-watering clash on Saturday.
Garcia's men have won all six games so far this season and have a two-point cushion over second-place Napoli, but Inter have home advantage and will be out to close the gap at the top.
Like Roma and Napoli, they are unbeaten in the league and sit fourth with 14 points.
An intriguing weekend of fixtures also sees Juventus face Milan and Lazio going head-to-head with Fiorentina.
Champions Juve play host to a Milan side who will be without the suspended Mario Balotelli - following his red card against Napoli - while Lazio and Fiorentina currently sit in sixth and fifth respectively, with only one point separating them after they both drew last week.
At the foot of the table, Sassuolo have two points thanks to back-to-back draws and they face a difficult trip to Parma, who come into the game on the back of an impressive 2-2 draw against Fiorentina.
Menawhile, Sampdoria know that a win this weekend can haul the club out of the relegation places and propel Delio Rossi’s men up to as high as 15th, but opponents Torino will be looking to bounce back after a 1-0 defeat to Juventus in the Turin derby last time out.
The mid-table clash between Udinese and Cagliari could be set up to prove one of the games of the weekend, with both sides sitting on the same number of points and an identical goal difference. They have picked up seven points so far from six games, with Cagliari heading into the match having drawn their last four league matches.
A 2-0 win away at Genoa kept Napoli in the hunt for top spot and Rafael Benitez's men will be hoping to banish the memories of their midweek defeat to Arsenal in the UEFA Champions League - Benitez's first competitive loss in charge.
Livorno will be the visitors to the Stadio San Paolo on Sunday.
Both Bologna and Chievo, 18th and 17th respectively, are desperate for points in the battle to pull away from the drop zone and they face two sides, Hellas Verona and Atalanta, who both won last time out.
Elsewhere, Catania host Genoa, with the home side full of confidence after beating Chievo 2-0 in their last game.
|Coach: W. Mazzarri|
for Á. Pereira 46'
for S. Taïder 57'
for F. Guarín 70'
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