Bayer Leverkusen can end Bayern Munich's unbeaten start to the Bundesliga for a second consecutive season when the sides meet on Saturday.
Leverkusen were the last side to beat Bayern in the league, recording a 2-1 victory in October 2012 to end their undefeated start to last term.
However, the champions recovered to go on a 32-game unbeaten run, with their most recent victory yielding a 1-0 victory over Wolfsburg last weekend.
Both sides have been in excellent domestic form this season and will go into the clash at the BayArena off the back of wins in the UEFA Champions League on Wednesday.
Pep Guardiola's Bayern have conceded one goal away from the Allianz Arena in the Bundesliga this season while Leverkusen have struck 12 goals at home with a win for either side able to move them top of the table.
That is dependant on leaders Borussia Dortmund dropping points in their away fixture against Borussia Monchengladbach.
Jurgen Klopp's side picked up their first points of the current Champions League campaign with a 3-0 win over Marseille on Tuesday thanks to the in-form Marco Reus and Robert Lewandowski.
The pair scored twice each in Dortmund's 5-0 success against Freiburg on Saturday and were again on target in Europe, with the league's leading scorer Lewandowski scoring twice against Elie Baup's men.
Werder Bremen will hope to maintain their mini-revival against Stuttgart, having gone two games without defeat after three successive losses, while Bert van Marwijk can pick up his first Bundesliga points as Hamburg boss.
His charges face Nuremberg and the Dutchman has been pleased with what he has seen from his new side since taking over from Thorsten Fink in September.
"We are satisfied with the (draw against Eintracht Frankfurt) and the team put some of the things into practise that we had planned beforehand, like for instance everyone in the team defended," he told the club's official website.
"We will surely need a few weeks to swim clear of the lower regions of the table."
Winless Eintracht Braunschweig travel to Wolfsburg while Schalke will hope to build on their Champions League success against Basel on Tuesday when they host Augsburg.
Mainz will aim to avoid a fifth straight league defeat against Hoffenheim with Hertha Berlin able to leapfrog their opponents on Saturday, Hannover, with a draw at the HDI-Arena.
Both sides have registered just one victory in their last three games going into Friday's clash, with Hannover having won one of the sides' last five meetings.
The final game of the weekend sees winless Freiburg host Frankfurt on Sunday.
|Coach: S. Hyypiä|
for E. Can 68'
for S. Sam 82'
for S. Kießling 83'
|Watford show support for assaulted fan as police charge six|
|Ibrahimovic to miss PSG opener|
|Klopp suited to Bayern job - Watzke|
|Eredivisie season-opener postponed due to police strike|
|Dortmund v Wolfsberger: Tuchel set for home bow|
|Griezmann at the double in Atletico win|
|Japan v South Korea: Halilhodzic calls for ´pride´|
|Mourinho enjoying improved relationship with Abramovich|
|Gradel agrees Bournemouth return|
|Inter switch an ´easy decision´ for Miranda|
|Bojan eyes early comeback|
|Vitesse hopeful over Solanke loan deal|
|Pedro will decide his own future - Luis Enrique|
|Iniesta handed Barcelona armband|
|Kukesi punished after Europa League abandonment|
|Leno hints at Leverkusen exit|
|Benitez explains Ronaldo absence|
|Pochettino backs Kane to be among world´s best|
|Messi not ruled out of Mexico friendly - Martino|
|China v North Korea: Kim´s side look for another win|
|River Plate v Tigres UANL: Copa Libertadores final evenly poised|
|Torres: I´d give my life to win La Liga with Atletico|
|Real target Ceballos focused on Betis - Mel|
|Platini can lead FIFA change - Fernandez|
|Mel: Betis won´t be signing Osvaldo|
|Ferrero defends Samp boss Zenga|
|Pochettino expects Spurs improvement|
|Bale ideal for United - Robson|
|Ferdinand: Di Maria will regret United failure|
|Benitez pleased with goalkeepers as De Gea transfer saga continues|
|Guardiola tips fit Schweinsteiger to shine|
|Confident Oxlade-Chamberlain hits back at Keane|
|Ferdinand: Stones would be ´a lunatic´ to join Chelsea|
|Qarabag v Celtic: Gordon wants positivity from Scottish champions|
|Higuain rejects extension from Napoli|
|Zamora returns to Brighton|
|West Ham can cope without Valencia - Gold|
|Wickham loses on Palace debut|
|Guardiola: No problem with Matthaus and Effenberg comments|
|Cartabia excited by Deportivo loan|
|Lyon confirm Rafael deal|
|Hysaj agrees deal to follow Sarri to Napoli|
|Rafael says his goodbyes to Manchester United|
|Dos Santos ready to get going with Galaxy|
|Pochettino rejects Soldado exit talk|
|Metatarsal misery for Mulumbu|
|Benitez: Benzema and Bale going nowhere|
|Mihajlovic: Ibrahimovic would make Milan title contenders|
|Hughes not taking any risks with Bojan|
|Guardiola relishing Audi Cup test|
|Di Maria ´taking a step up´ - Silva|
|Leicester bring in defender Benalouane|
|Deulofeu doubtful for Premier League opener|
|West Ham striker Valencia out for three months|
|UEFA: Qarabag-Celtic to go ahead|
|Palace seal Wickham swoop|
|Ronaldo and Benzema to miss Audi Cup|
|Marotta: Juventus could lose Pogba|
|Kante completes Leicester switch|
|Khedira ruled out for two months|
|FA accepts Mourinho criticism of Wembley surface|
|Robben rubbishes injury talk|
|Marchisio expects Milan title challenge|
|Rafael set for Lyon move|
|Celtic ´seeking reassurances´ over Qarabag pitch|
|Wenger beating Mourinho does not affect Chelsea - Zouma|
|Rooney moved by Everton welcome|
|Mancini not worried by lack of Inter goals|
|Coloccini wants to finish career at Newcastle - McClaren|
|Ramsey: Pressure to win trophies is nothing new|
|Terry: Wembley defeat could be a ´blessing in disguise´|
|Blatter not running for IOC re-election|
|Bendtner: Wolfsburg can challenge Bayern for Bundesliga honours|
|Liverpool relishing Britannia return, says Henderson|
|Everton big enough to keep Stones - Martinez|
|MLS Review: Fire stun Dallas as goals dry up|
|New Atletico signings excite Raul Garcia|
|Cahill expects Arsenal title challenge|
|Jovetic happy with Inter debut|
|Luis Enrique: Barca defence must improve|
|Yanev calls for calm after ugly scenes in friendly|
|Coppa Italia Review: Cittadella romp to victory, Brescia rely on penalties|
|Arsenal have learned how to play against big teams - Ramsey|
|Shawcross to visit specialist over back woe|
|Fiorentina 2 Barcelona 1: Bernardeschi double sends Barca to another defeat|
|Mancini hints at Melo interest|
|Rodgers hails ´incredible´ Benteke strike|
|Galatasary 1 Inter 0: Sneijder sinks former club|
|Wenger defends Arsenal approach|
|Wembley loss has no bearing on new season - Terry|
|Porto cruise to friendly win over Stoke|
|Mourinho denies Wenger ´snub´ suggestions|
|Arsenal abandoned their philosophy to win Community Shield - Mourinho|
|Mourinho throws Community Shield medal into Wembley crowd|
|Swindon Town 1 Liverpool 2: Benteke nets stunner on debut|
|Scottish Premiership Review: Hearts win thriller on top-flight return|
|Ujah at the double as Bremen beat West Ham|
|Mourinho: We were the better team|
|Wenger hails defensive solidity|
|Rooney returns as Villarreal spoil Ferguson´s party|
|Rodriguez stunner earns Southampton draw as Caulker makes debut|
|Arsenal 1 Chelsea 0: Case of 14th time lucky for Wenger against Mourinho|
|Taechaubol announces Milan agreement|
|Jojic fires Cologne to latest victory|
|China 0 South Korea 2: Kim and Lee seal victory|
|Origi getting up to speed|
|Costa a doubt for start of season - Mourinho|
|North Korea 2 Japan 1: Halilhodzic´s men spurn lead|
|Allam brands FA ´amateurs´ as name-change row rumbles on|
|Fournier ´worried´ by Lyon pre-season|
|Swansea still working on Michu exit - Monk|
|Neuer furious at Bayern Supercup defeat|
|Wenger: Ozil signing not a mistake|
|UEFA Champions League Preview: Shakhtar ready for Fenerbahce decider|
|Lampard targets MLS play-offs for City|
|MLS Review: Goals galore as DC United win 10-goal thriller|
|Ronaldinho returns and helps Fluminense to win|
|Keane: United won´t overtake Chelsea|
|Casillas has the ´enthusiasm of a 20-year-old´ - Lopetegui|
|Blanc hopeful over Ibrahimovic knee injury|
|Guardiola laments late goal in Supercup defeat|
|Tuchel plans to keep Bender|
|Hecking happy with Wolfsburg discipline after Supercup win|
|Arsenal players too interested in selfies and six-packs - Keane|
|Confusion over Ibrahimovic´s PSG future|