Chief executive Shaun Harvey says The Football League have had no contact from police regarding alleged match-fixing in the United Kingdom.
Six people have been arrested as part of a match-fixing investigation, police in the UK confirmed on Wednesday.
The country's National Crime Agency (NCA) revealed that the individuals had been taken into custody as part of an operation centring on possible illegal betting activity on matches.
While the individuals have not been named, national media reports allege the men being held include footballers.
The English Football Association have confirmed they are working with police.
Harvey said he understood the seriousness of the allegations but said The Football League were yet to speak to police.
"We understand from media reports that there is an ongoing police investigation into alleged match-fixing in domestic football," he said in a statement.
"To date, we have had no contact from the police regarding this matter.
"The threat of corruption is something that The Football League and the other football authorities treat with the utmost seriousness.
"The integrity of our matches and our competitions is the bedrock of the domestic game."
In a separate statement, the FA said: "The FA has been made aware of a number of arrests in relation to an NCA (National Crime Agency) investigation.
"We have worked closely with the authorities in relation to these allegations.
"The FA will make no further comment at this time due to ongoing investigations."
Earlier, the NCA, set up by the British government earlier this year to lead the UK's fight against serious and organised crime, confirmed the arrests.
"Six men have been arrested across the country as part of an NCA investigation into alleged football match-fixing," the NCA said.
"The focus of the operation is a suspected international illegal betting syndicate.
"The NCA is working closely with the Gambling Commission and the Football Association.
"This is an active investigation and we are unable to provide further detail at this time."
|Napoli to refuse questions on Benitez´s future|
|USDoJ names indicted FIFA officials|
|Wenger coy over Vidal and Benzema moves|
|Suarez back in training ahead of Copa final|
|Pique: I´ll retire at Barca|
|Gerrard ´blown away´ by Liverpool send-off|
|FIFA ´very happy´ with Zurich arrests|
|Liverpool defender Toure targeting trophies|
|Ramsey eyeing title assault|
|Welbeck out of FA Cup final and England matches|
|FIFA the ´injured party´ as Swiss prosecutors open criminal proceedings|
|Prince Ali saddened by FIFA arrests|
|Pellegrini to make City defence a priority|
|Labbadia giving Lasogga, Olic, Jiracek time|
|Ramsey confident on Wembley chances|
|Swiss authorities confirm FIFA arrests|
|El Shaarawy open to Premier League move - agent|
|Reports: FIFA officials set to be arrested|
|Tigres UANL 2 Emelec 0 (2-1 agg): Mexicans through to Libertadores semis|
|Valencia ruled out of Copa America|
|Coleman: Bale being ignored by Real team-mates|
|Ruddy eyes England recall|
|Benteke will strike fear into Arsenal - Westwood|
|Howe named LMA Manager of the Year|
|Casillas reiterates desire to stay in Madrid|
|Dnipro players pay for fans´ tickets, transport|
|Galliani: I want Ancelotti back at Milan|
|Premier League: Manchester City season review - Frustrations as latest title defence falters|
|Injured Benfica star Salvio not for sale|
|AFC Champions League Review: Al Sadd suffer last-16 exit|
|Emery targeting historic victory|
|Toure and Wisdom pen new Liverpool deals|
|Stadium facilities drive Van Gaal potty|
|Blatter brushes off Figo´s ´dictatorship´ claims|
|Mavuba to end career at Lille after extending contract|
|Ipswich´s Bishop charged over betting breaches|
|Markevych admits to Dnipro nerves|
|Relegated Almeria to be deducted three points|
|Reims retain Guegan on one-year deal|
|Di Matteo departure could hinder Schalke swoop for Khedira|
|Bale planning Real Madrid stay|
|Del Bosque not prepared to risk Costa|
|West Ham earn Europa League berth|
|Pellegrini sure City will win title back|
|Low calls Herrmann into Germany squad|
|Gerrard will win trophies with Galaxy - Carragher|
|Frankfurt agree to let Schaaf leave|
|Hernandez hit with violent conduct charge|
|Bale set for 50th Wales cap against Belgium|
|Baines hoping for pre-season return|
|Bournemouth sign Boruc|
|Sevilla duo Rico and Vidal handed Spain calls|
|Premier League: Chelsea season review - Mourinho´s men canter to title|
|Speroni hints at possible Palace exit|
|Kane states Tottenham commitment|
|Boruc, Hooiveld leave Southampton|
|Oxlade-Chamberlain desperate to make FA Cup final|
|Roar turn to Aloisi|
|Di Matteo resigns as Schalke coach|
|Hughes hints at Moses return|
|Wenger hits out at scheduling|
|Terry backs Chelsea to dominate|
|Jets part ways with coach Stubbins|
|Kewell would love to manage Liverpool|
|Janmaat: Newcastle players failed Carver|
|Adelaide step up interest in Toni|
|Chelsea´s Drogba interested in MLS move|
|Otamendi wants to leave Valencia - agent|
|Benitez almost certain for Real job|
|Schneiderlin will leave for Champions League club|
|Kane planning to come back bigger and better|
|Moyes staying at Sociedad|
|Neil revels in Norwich promotion|
|Drogba interested in MLS move|
|Russian Premier League Review: Torpedo keep survival hopes alive|
|Turkish Super Lig Review: Galatasaray crowned champions as Fener have four sent off|
|Ghana 1 Madagascar 2: Simouri nets late winner|
|Galatasaray reclaim title as Fener implode|
|Ancelotti bears no grudge after Real sacking|
|Porto complete Bueno capture|
|Lazio 1 Roma 2: Yanga-Mbiwa settles Rome derby|
|Real sack Ancelotti|
|Route to the UEFA Europa League final: Sevilla|
|Derby sack McClaren|
|Eredivisie play-offs Review: Eagles relegated, NAC Breda earn reprieve|
|Inzaghi eager for Van Ginkel stay|
|Route to the UEFA Europa League final: Dnipro|
|Dani Alves plays down Champions League favourites tag|
|Middlesbrough 0 Norwich City 2: Jerome and Redmond send Neil´s men up|
|Renard takes over at Lille|
|Cancelo completes permanent Valencia move|
|Dnipro v Sevilla: Emery embracing chance at history|
|Kuchuk leaves Kuban Krasnodar|
|Desailly hails Terry and urges calm over Zouma|
|Guardiola has built on Heynckes´ Bayern legacy - Muller|
|Falcao thanks United fans|
|Zorniger takes Stuttgart role|
|Dani Alves to clarify Barca future after Champions League final|
|Pazzini in the dark over Milan future|
|Barzagli a doubt for Champions League final|
|Clough sacked by Sheffield United|
|Pardew eyeing ´quality´ signings|
|Carver encouraged by Ashley´s Newcastle promises|
|Gutierrez revels in Newcastle ´fairytale´|
|Relegation will haunt Hull - Chester|
|El Shaarawy eyes Italy call-up|
|Crouch delighted by headed goals record|
|Ancelotti all but confirms Real exit|
|Platini: FIFA will lack credibility if Blatter remains president|
|Bilbao duo pen new deals|
|Rooney: United can win title next season|
|Argentine football rocked by second death|
|Leicester must aim higher next season - Pearson|
|Monk negotiating new Swansea contract|
|Ox can play in cup final, says Wenger|
|Century of MLS goals ´surreal´ for Wondolowski|
|Copa Libertadores Preview: River not giving up hope|
|Cahill returns for Australia´s World Cup qualifier in Kyrgyzstan|
|MLS Review: Wondolowski joins 100-goal club|
|Toni on track for Hellas Verona´s maiden golden boot|
|Amid Ancelotti speculation, Galliani confirms Madrid trip|
|Berlusconi targets Ancelotti, Inzaghi remains committed to Milan|