Ten-man Real Madrid scored in a record 30th consecutive UEFA Champions League game as they beat Galatasaray 4-1 to qualify for the last 16.
Carlo Ancelotti's side shrugged off the first-half dismissal of Sergio Ramos, the 17th red card of his Real career, with goals from Gareth Bale, Alvaro Arbeloa, Angel di Maria and Isco eclipsing Umut Bulut's strike.
Ramos' match was ended for a foul on Bulut after just 26 minutes, although the Turkey international appeared to make the most of minimal contact when he was through on goal.
Bale rifled in a long-range free-kick eight minutes before the interval, only for Bulut to level almost immediately.
However, Arbeloa provided a collector's item of a goal in the second half, finding the net for the first time since November 2010, Di Maria added the third and Isco completed the scoring nine minutes from time to wrap up Group B's top spot for the hosts.
Real were without Cristiano Ronaldo (thigh), who was nonetheless the centre of attention in the build-up as the Real fans showed their support for the forward's bid to be crowned FIFA Ballon d'Or winner by displaying banners and wearing masks of the Portuguese's face.
Coach Carlo Ancelotti also rested Xabi Alonso, Karim Benzema and Alvaro Morata, with Jese Rodriguez selected up front and Casemiro handed his debut in the competition.
Opposite number Roberto Mancini, who was not in charge when the Turkish side were humbled 6-1 in the reverse fixture, left Burak Yilmaz and Wesley Sneijder on the bench.
Real should have taken the lead inside the opening four minutes when Bale was sent racing clear by Isco, but the Welshman side-footed wide with only the goalkeeper to beat.
The home side threatened again six minutes later as Marcelo cut in from the left and tried to pick out Rodriguez, but Selcuk Inan's desperate challenge denied the Spaniard a shooting opportunity.
Inan also had the visitors' first sight of goal but flashed an ambitious long-range shot over the bar from a tight angle in a rare Galatasaray attack.
But the momentum threatened to shift when Ramos, who was the last man, was given his marching orders after making the slightest of contact with a goal-bound Bulut.
Jese had to make way in the tactical reshuffle as Nacho was introduced, but Bale put the 10 men ahead eight minutes before half-time with a dipping 25-yard free-kick that looked to have deceived Eray Iscan.
The lead was short-lived, however, as Bulut collected Didier Drogba's pass before coolly slotting past Iker Casillas two minutes later.
Real went back ahead six minutes after the restart, Di Maria swinging in a low cross from the left to find the most unlikely of scorers in Arbeloa, who tucked home with surprising confidence amid suspicions of offside.
Arbeloa's spell in the spotlight did not end there and he was booked for diving in the 55th minute, before turning provider for Di Maria with 63 minutes gone.
Casillas produced a stunning save from Drogba's header before Isco added the fourth with a clever turn and finish in the box and there there was no way back for Mancini's men, who must now beat Juventus in the final group game to qualify.
|Griezmann hails ´brilliant´ Gameiro as Atletico see off Leverkusen|
|Simeone all smiles after Atletico dismantle Leverkusen|
|Spot-kick revision pays off for Caballero|
|Championship Review: Huddersfield boost top-two hopes, Wednesday beaten|
|Toprak laments bad result as Leverkusen lose at home to Atletico|
|Aguero grapples for glory as strikers shine in Manchester City v Monaco|
|Bayer Leverkusen 2 Atletico Madrid 4: Simeone´s side in control|
|Manchester City 5 Monaco 3: Guardiola´s side prevail in all-time classic|
|AFC Champions League Review: Al Rayyan and Al Ahli off to winning starts|
|Ranieri: Sevilla game can be a turning point for Leicester|
|Allegri confirms Bonucci absence after row|
|Nuno confident Porto can beat Juventus|
|Matthaus encourages Gotze to stay at Dortmund|
|Martial: I love Manchester United and I want to stay|
|I would never force out Manchester United legend Rooney - Mourinho|
|Anderlecht insist Tielemans not leaving on the cheap|
|Leicester can´t afford to live in the past, warns Sampaoli|
|Porto´s home comforts, shot-shy Leicester & Sevilla meet - Champions League in Opta numbers|
|Puyol backs Barcelona for Champions League miracle|
|Sutton´s pie-munching keeper Shaw resigns|
|Coyle leaves struggling Blackburn|
|Sampaoli noncommittal on Sevilla future despite contract offer|
|Higuain backs Dybala to become ´among the best in the world´|
|Ancelotti escapes punishment for middle finger|
|Pie-eating Sutton goalkeeper´s antics under investigation|
|AFC Champions League Review: 2014 winners Wanderers thrashed, Hulk inspires 10 men|
|Zidane reveals Ronaldo´s favourite position|
|Lippi backs Allegri for Juve stay|
|Zidane: Isco knows I love him|
|Rooney returns to United training|
|Higuain confident Juventus can win Champions League|
|Giggs the dream pro-am partner for Manchester United fanatic McIlroy|
|Kane hopes Spurs can get used to Wembley|
|Hazard: I gave everything to come back|
|Like Cantona, Ibrahimovic embraces United pressure - Giggs|
|Wenger: Perez deserves more chances|
|Wenger denies using Sanchez was risky|
|Tite: I wish Messi was born in Brazil|
|Jardim praises ´great striker´ Falcao|
|Reported Barcelona target Sampaoli offered Sevilla extension|
|´Angry´ Messi didn´t celebrate because of criticism – Bauza|
|´He is going to have to do it himself´ – Guardiola backs Aguero|
|Toure backs Sterling and Sane for the top|
|Pique: Barcelona were in deep s*** when Luis Enrique arrived|
|Thoughts of Bayern mauling stopped Wenger from enjoying Arsenal FA Cup win|
|Sutton United 0 Arsenal 2: Perez and Walcott break minnows´ stern resolve|
|Walcott brings up 100 goals for Arsenal|
|Simeone will make late Oblak call for Leverkusen clash|
|AFC Champions League Review: In-form El Arabi gives Lekhwiya dream start, Diop saves Al Ahli|
|Fabinho disagrees with Guardiola over favourites tag|
|Guardiola hails Bielsa as best in the world|
|Jardim insists Monaco will not change style for Manchester City clash|
|Clattenburg´s Premier League career not over yet|
|Dortmund could renew Tuchel deal|
|Chicharito return to form boosts Schmidt´s Leverkusen for Atletico test|
|Iniesta sees Verratti as his successor - Matuidi|
|Ramos did not make history at Sevilla like me - Alves questions Real Madrid captain|
|Vertonghen feels Tottenham deserve silverware|
|Agent denies Lucas Perez exit claims|
|Barcelona forward Neymar to stand trial after losing appeal|
|City history can´t compare to United, Liverpool – De Bruyne wants to make Champions League impressio|
|Europa League the priority for United´s Mata as EFL Cup final looms|
|Winning the FA Cup ´may not save Wenger´|
|Falcao perfect for ´killers´ Monaco - Guardiola wary of Champions League threat to Manchester City|
|Ancelotti asked to explain middle finger gesture|
|Ribery closing in on Bayern Munich return|
|Nani eager for improving Valencia to tackle Real Madrid|
|Rashford eyes Chelsea revenge after huge FA Cup draw|
|Glorious Griezmann and Aguero´s knockout drought - Champions League in Opta numbers|
|Otamendi´s agent talks up Real Madrid switch|
|He has to get used to it – Montella reacts to Bacca boos|
|Low hopes to discover Germany´s Luis Suarez|
|Mourinho unsure if Rooney will recover for EFL Cup final|
|Rami rejects talk of Marseille switch|
|Tarnat tips Manchester City´s Sane to become Germany star|
|I don´t see why he should quit - Begovic tips Terry to continue|
|PSG ´weakened´ without Ibrahimovic, claims Monaco´s Bakayoko|
|Low believes in ´locksmith´ Gotze|
|No pain, no gain for Cristiano Ronaldo|
|Barcelona have no idea how to treat players - Dani Alves slams Camp Nou board|
|Low: Germany´s youngsters must be good enough to beat Messi and Ronaldo|
|Mandorlini replaces Juric at Genoa|
|Liverpool could face ´new´ Leicester – Klopp|
|Corchia excited by Bielsa arrival but Lille future remains uncertain|
|Wenger: I threw up after first loss as coach|
|Conte wants fairytale finish for Terry|
|Iniesta: Barcelona haven´t lost faith in Luis Enrique|
|Mourinho knew Ibrahimovic would be ´massive´ for United|
|Ter Stegen doesn´t understand Barcelona fans whistling|
|´He is doing a fantastic job´ – Bartomeu backs Luis Enrique|
|Guardiola slams ´unacceptable´ Wenger treatment|
|Spalletti: Roma goal machine Dzeko now believes he´s world class|
|Emery refuses to blame referee after PSG are held|
|Montella dedicates AC Milan win to Berlusconi|
|The players don´t need whistles – Luis Enrique hits out at fans|