Part of the stadium due to host the opening match of the 2014 FIFA World Cup has collapsed, killing two construction workers at the site.
The roof at the Arena de Sao Paulo, in the Itaquerao district of the city, suffered damage following an accident on Wednesday which involved a crane working on the construction.
According to a statement from Brazilian club Corinthians and building firm Odebrecht, the crane, designed to put the final piece of the metal roof structure in place, collapsed and caused the fall of part of the east building.
It read: "Odebrecht Infraestrutura and Sport Club Corinthians Paulista regret to inform you that in the early afternoon an accident in the work of Arena Corinthians caused the death of two workers - Fabio Luiz Pereira, 42, driver/operator of the company BHM Munck, and Ronaldo Oliveira dos Santos, 44, assembler of Conecta company.
"Shortly before 1pm, the crane that hoisted the last module of the structure of the metal roof of the stadium collapsed causing the fall of the part of the circulation area of the east building - partially hitting the LED facade.
"The structure of the grandstand was not compromised. It was the 38th time this type of procedure happened in the place and a part with the same proportions was installed just over a week in the southern sector of the stadium.
"Firemen are working in the place. At the moment, all efforts are focused to provide full assistance to the families of the victims."
FIFA also expressed their condolences, releasing a statement of their own shortly after the incident.
It read: "FIFA and the LOC have learnt of the death of workers at the Corinthians Arena site in Sao Paulo with great sadness. We wish to send our heartfelt condolences to the family of the workers who tragically died today.
"The safety of workers is the top priority for FIFA, the LOC, the federal government. We know the safety of all workers has always been paramount for all the construction companies contracted to build the 12 FIFA World Cup stadiums.
"The local authorities will fully investigate the reasons behind such a tragic accident.
"We are in no position to comment further at this stage, as we are awaiting further details from the authorities. As soon as FIFA receives further information, we will provide an update."
FIFA president Sepp Blatter, meanwhile, added via his Twitter account: "I'm deeply saddened by the tragic death of workers @Corinthians arena today. Our heartfealt (sic) condolences are with the families."
The venue had been chosen to host the first game of the showpiece tournament on June 12, with FIFA having set a strict deadline of the end of December for all venues to be completed.
A total of six games are due to be played at the stadium, which was reported to be 94 per cent complete earlier this month.
|Kuyt eyes trophies on Feyenoord return|
|Chile v Argentina: History beckons ahead of Copa America final|
|Wallace extends Monaco loan|
|Mihajlovic wants to instill fear factor at Milan|
|Mignolet improving at Liverpool - Grobbelaar|
|Mumbai City name Anelka player-manager|
|Olivia the parrot predicts Japan to win Women´s World Cup|
|Lusitans coach blasts Bilic´s ´lack of respect´|
|Sakho eyes more Europa League wins|
|Gareca wants Peru to keep building|
|Chile ´no chance´ if Argentina produce their best - Diaz|
|Ocampos joins Marseille permanently|
|Europa League Review: Cloud-nine Brondby ignite opening round|
|West Ham 3 Lusitans 0: Sakho nets twice at start of Europa League journey|
|Holebas makes Watford move|
|Milan secure Adriano signing|
|Peru v Paraguay: Diaz counts cost of semi-final loss|
|Bastia hit out at reports of extra debt|
|Hernandez has successful surgery|
|Odemwingie signs one-year Stoke extension|
|Uth signs for Hoffenheim|
|Henen seals Everton return|
|Cattermole pens long-term Sunderland deal|
|United States v Guatemala: Klinsmann backs Dempsey ahead of Gold Cup warm-up|
|West Ham working on Jenkinson return - Gold|
|Milan agree deal for Bacca|
|Real buy back Vazquez from Espanyol|
|Richards leaves Swansea for Fulham|
|McShane signs for Reading|
|Giggs tells youngsters to seize US chance|
|Hammond pens Leicester extension|
|Only Schweinsteiger can decide Bayern future - Guardiola|
|Cech plans to play until he´s 40|
|Montoya arrives in Milan ahead of Inter move|
|Hernandez out of Gold Cup|
|US asks Switzerland to extradite seven FIFA officials|
|MLS Preview: Sounders seek momentum switch|
|Mexico 0 Honduras 0: Hernandez injury sours friendly|
|Hernandez taken to hospital|
|Garay in doubt for Copa America final|
|Wambach: USA peaking for World Cup final|
|Bassett ´an absolute hero´ despite own goal - Sampson|
|Japan 2 England 1: Late own goal breaks English hearts|
|Salvo quits as Valencia president|
|Costa not Ribery cover - Bayern director Sammer|
|Chile, Argentina deserve final spots - Mena|
|Ramos keen on United switch - Calderon|
|B36 1 The New Saints 2: Wilde leaves it late to secure advantage|
|Sevilla agree deal for Rami|
|Celtic snap up United teenager Janko|
|Beauvue passes Lyon medical|
|Roma bring in Falque|
|Coates completes permanent Sunderland switch|
|Vallecano to make charity donations from shirt sales|
|Angella commits to Watford|
|Gundogan pens new Dortmund deal|
|Juve reject €80million Barca offer for Pogba, says Marotta|
|Ruiz seals permanent Villarreal move|
|Mourinho respects Cech´s decision to quit Chelsea|
|Claridge excited by potential Pearson successors|
|Miranda completes Inter switch|
|Blind takes over as Netherlands coach|
|Mourinho: Premier League tougher to win than ever|
|Hamburg make Holtby move permanent|
|Southampton terminate Osvaldo contract|
|BREAKING NEWS: Swansea swoop for Eder|
|Abbiati extends Milan stay|
|Cruyff: Barcelona have lost their values|
|Vydra seals Watford move|
|Ambitious Clyne targets trophy haul with Liverpool|
|Claridge: Off-field incidents cost Pearson his job|
|Clyne becomes Liverpool´s sixth close-season signing|
|Imbula leaves Marseille for Porto|
|FIFA chief Blatter challenges critics to prove corruption claims|
|Distin joins Bournemouth|
|Bayern seal Costa deal|
|Arsenal confirm Diaby departure|
|Blatter to miss Women´s World Cup final|
|Bogdan sets sights on being Liverpool number one|
|Danilo eager to get started at Real Madrid|
|Leicester´s Wood joins Leeds|
|Porto confirm Atletico move for Martinez|
|Lloyd: Repetition key to netting penalty|
|Sheffield Wednesday job a ´dream´ for Carvalhal|
|´We played a complete game´ - Messi|
|Diaz upbeat despite heavy Copa loss to Argentina|
|Martino lauds Messi for selfless performance|
|Viviani makes surprise Verona switch|
|Estonian team wins cup match 31-0|
|No meeting with Arsenal has occurred - Vidal´s agent|
|United States 2 Germany 0: Ellis´ team reach World Cup final|
|Argentina 6 Paraguay 1: Messi leads Martino´s men to Copa final|
|UEFA Europa League Review: FK Zeljeznicar and FC Dacia Chisinau open with wins|
|UEFA Champions League Review: FC Pyunik make winning start|