AC Milan halted a seven-game winless slump by clinically ending Celtic's UEFA Champions League campaign with a 3-0 win in Glasgow.
Celtic were backed by the cacophony of noise synonymous with their Champions League nights at home on Tuesday, but slack set-piece defending decisively undermined their efforts in this must-win Group H encounter.
Kaka and Cristian Zapata were the beneficiaries either side of half-time, leaving Mario Balotelli to seal the points on a night when the enigmatic Italy international proved a thorn in the side of the home defence.
Ajax's shock win over Barcelona means Celtic are unable to even secure the consolation of a Europa League place, while Milan must avoid defeat against the Dutch champions at San Siro in a fortnight’s time to secure their passage.
Neil Lennon made four changes to his Celtic starting XI, including a decision to start James Forrest despite the winger being arrested earlier on Tuesday over an alleged sexual assault.
Balotelli led Milan's attack, while Valter Birsa and Riccardo Montolivo came in for Alessandro Matri and Sulley Muntari after Saturday’s 1-1 draw with Genoa.
Derk Boerrigter should have put Celtic ahead on his first Champions League start for the club after just two minutes, but he scuffed a back-post volley after Milan goalkeeper Christian Abbiati made the first of a series of misjudgements from Charlie Mulgrew's corner.
A minute later, Balotelli botched a chance to open the scoring as he dragged wide having escaped the attentions of the home defence.
Milan defender Zapata produced a vital last-ditch tackle when Mulgrew's ninth-minute shot fell to Beram Kayal in front of goal, and the visitors were ahead soon after.
Kaka was left completely unmarked to nod home at close quarters as goalkeeper Fraser Forster elected to stay on his line from Birsa's right-wing corner.
Daniele Bonera then made a timely block after Mulgrew picked out Boerrigter, but Celtic were almost hit on the break immediately as Kaka released Balotelli to drill narrowly over.
Celtic continued to press manfully before the break but their fate was sealed by two key incidents shortly after the resumption.
Centre-back Virgil van Dijk smashed a volley into Abbiati from point-black range when it might have been easier to score in the 47th minute - and his defensive colleagues were once again undone from a set-piece two minutes later.
Birsa's delivery was superb again, and half-time substitute Antonio Nocerino knocked across goal for Zapata to apply the finish.
To compound Celtic's misery, Balotelli sealed the points with an hour played after Van Dijk had headed home from an offside position.
The former Manchester City striker demonstrated his pace, power and poise to hold off Efe Ambrose and finish Montolivo’s lofted pass.
Forrest almost reduced the arrears when he poked wide from Mikael Lustig’s ball with the impressive Nigel de Jong in close attendance.
The game the petered out as Celtic's enthusiasm faded and Massimiliano Allegri's men kept their hopes of reaching the last 16 very much alive.
|Sampdoria not a ´discount store´ - president Ferrero|
|Montolivo: No issue with Mihajlovic|
|Gilardino signs for Palermo|
|Chelsea target ´China´s Sergio Ramos´|
|Striker search like looking for love - Pochettino|
|Hecking ´sick´ of De Bruyne talk|
|Deschamps calls up Martial, leaves out Sakho|
|´The only thing they can is long balls´ - Midtjylland´s skipper slams Southampton|
|UEFA Europa League Review: Reus leads Dortmund rout, AZ complete late comeback|
|Messi should win Ballon d´Or - Bartomeu|
|Koeman rues refereeing decisions after Europa League defeat|
|Tottenham deal for Son not complete, say Leverkusen|
|Tuchel thrilled with aggressive Dortmund display|
|Midtjylland 1 Southampton 0 (2-1 agg): Premier League side crash out|
|Borussia Dortmund 7 Odd 2 (11-5 agg): Reus hat-trick highlights hammering|
|Cudicini tips Mourinho to avoid Porto upset|
|Anything is possible with Neymar´s future - Belletti|
|Burnley bring in Barton|
|Bayern Munich v Bayer Leverkusen: Vidal putting friendships on hold|
|De Bruyne edges closer to City move after further Wolfsburg talks|
|Real Madrid v Real Betis: Benzema back as Real look to hit the goal trail|
|Barcelona v Malaga: Rosales hopes for another upset|
|West Brom hit out at Tottenham´s Berahino pursuit|
|Stoke City v West Brom: Pulis set for Britannia return|
|Tottenham v Everton: Pochettino´s men eye first win|
|Everton reject Stones´ transfer request|
|Messi named UEFA Player of the Year|
|Pocehttino quiet on Berahino bids|
|Real Madrid to meet PSG in Champions League, Barca drawn with Leverkusen|
|Bournemouth v Leicester City: Howe eager to entertain|
|Ranieri coy on Gray link|
|Newcastle United v Arsenal: Wenger hopes for sharper shooting|
|PSG snap up Kurzawa from Monaco|
|Aston Villa v Sunderland: Sinclair aims to replicate cup form|
|Grabban a silly boy - Neil|
|Chelsea v Crystal Palace: Pardew braced to face stronger champions|
|Manchester City v Watford: Flores heads to Etihad with confidence|
|Marseille loan Real Madrid youngster Lucas Silva|
|Howe surprised by Harte´s retirement|
|Liverpool v West Ham: History counts for nothing, says Bilic|
|Bolasie set for Palace comeback|
|De Bruyne to City not a done deal - Allofs|
|Sevilla complete Llorente swoop|
|Wenger supports video technology|
|Milan v Empoli: Zapata sets sights on ´must-win´ fixture|
|Watford boss Flores ´not happy´ with transfer situation|
|Balotelli: I am no longer a kid|
|Bilic has no issue with Valencia|
|Arsenal ´not close´ to any late deals|
|Balotelli finalises return to Milan on loan|
|West Ham confirm Nolan departure|
|Thiago signs new Bayern deal|
|Schmidt saddened as Son nears exit|
|CONCACAF Champions League Review: Sounders lose in Honduras|
|Van Gaal considered early Herrera substitution|
|MLS Review: Fire stun Red Bulls|
|Carroll nears West Ham return|
|Rodriguez hoping for England recall|
|Leverkusen can challenge best - Schmidt|
|Ozil defends United recruit Schweinsteiger|
|Sporting ´better over two legs´ - Jesus|
|Stoilov revels in historic Astana triumph|
|Pioli: Lazio not ready for Champions League|
|UEFA Champions League Review: Rooney nets treble and Astana make history|
|Everton to reject Stones´ transfer request - Martinez|
|Barnsley 3 Everton 5 (aet): Delightful Deulofeu spares blushes for Martinez´s men|
|Van Gaal lauds Rooney character|
|Rooney delighted to be back in the goals|
|Club Brugge 0 Manchester United 4 (1-7 agg): Rooney ends goal drought with hat-trick|
|Juve striker Llorente undergoing Sevilla medical|
|Blanc confirms imminent Kurzawa switch to PSG|
|AFC Champions League Review: Lima gives Al Ahli the edge, Jeonbuk Motors and Gamba Osaka draw|
|Wanyama out of Euro tie with stomach infection|
|Digne joins Roma on loan from PSG|
|Monaco agree deal for Real´s Coentrao|
|Wolves reject third Norwich bid for Afobe|
|Valencia clarifies West Ham criticism of injury treatment|
|O´Neill hands duo Northern Ireland recalls|
|Illarramendi makes Sociedad return|
|Arsenal a player away from dominance - NBA star Deng|
|Godin ´always wanted´ Atletico stay|
|Schalke reject Roma´s Kolasinac bid|
|Injured Allen omitted from Wales squad|
|Bellerin ready for Debuchy battle|
|Valencia lashes out at West Ham treatment|
|Van Dijk hints at Celtic exit|
|Everton legend Gray resigned to Stones exit|
|Negredo: Suffering is in the past|
|Commons and Gordon reject Deila critcism after Celtic defeat|
|Neil remains defiant on Bournemouth target Grabban|
|Happy Milner optimistic about Liverpool chances|
|CONCACAF Champions League Review: DC United, Saprissa preserve perfect records|
|Tomkins eyes West Ham recall|
|Di Maria, Pastore out of Argentina squad|
|Schmidt unfazed by Lazio injuries|
|Pique hits back at Barca critics|
|Hurt Traore a ´marked man´ - Sherwood|
|Wolves reject second bid for Norwich target Afobe|
|Pardew fears ´long term´ Jedinak injury|
|Hughes thrilled with Bojan return|
|Maccabi´s Europe feat ´the high of highs´ for Ben Haim|
|McClaren expecting big things from Thauvin|
|Lucescu calls for Shakhtar improvement in group stage|
|Watford will learn from loss - Flores|
|Nuno revels in Valencia´s Champions League qualification|
|Advocaat unhappy despite win|
|League Cup Review: Preston claim Watford scalp, Luton lose shoot-out to Stoke|
|UEFA Champions League Review: Valencia make history for Spain, Celtic dumped out|