Real Sociedad need a win at Shakhtar Donetsk on Wednesday night to have any chance of prolonging their UEFA Champions League adventure.
The Spanish side are bottom of Group A with two games remaining and they must secure all three points at the Donbass Arena and hope Manchester United beat Bayer Leverkusen to avoid crashing out of Europe's premier club competition.
Jagoba Arrasate's charges picked up their first point by holding United to a 0-0 draw last time out and they will be out for revenge against the Ukrainian champions, who beat them 2-0 in San Sebastian back in September.
Sociedad come into the game on a high after a thrilling 4-3 win over Celta Vigo at the weekend and they occupy fifth place in the Liga table.
Striker Carlos Vela was the star of the show against Celta as he scored all four goals - including two in the space of three minutes late on - to seal a stunning victory.
Arrasate will be concerned by his side's form on their travels, however, as they have only won once on the road in the Spanish top flight this term to go with their 2-0 Champions League play-off win at Lyon in August.
Midfielder Markel Bergara will not feature on Wednesday after picking up his third yellow card in the competition against United.
Shakhtar are two points behind second-placed Leverkusen and three adrift of leaders United ahead of the final two group games - with their last match being at Old Trafford next month.
Mircea Lucescu's side have drawn their two home games in the group, but they will also come into the game on the back of an impressive victory, having beaten Sevastopol 4-0 at the weekend to cement top spot in the Ukrainian Premier League.
Shakhtar will be all but eliminated if they lose and the other game between Leverkusen and United at the BayArena is drawn.
Midfielder Bernard missed the resounding victory at the weekend as he had been away on international duty with Brazil, but could return for this crunch clash.
|20||Douglas Costa||68' 87'|
|Coach: M. Lucescu|
for Bernard 69'
for Luiz Adriano 72'
for Alex Teixeira 75'
|Ronaldinho to leave Atletico Mineiro|
|Lorient capture Ayew|
|Celtic loan Berget, sell Watt|
|Pires signs up for Indian Super League|
|Allegri set for early San Siro reunion in maiden Juve campaign|
|Bakayoko makes Monaco move|
|Bakayoko makes Monaco move|
|Lens granted Ligue 1 place|
|UEFA Champions League Preview: Red-hot Salzburg face Qarabag|
|Parma bring in Cassani from Fiorentina|
|De Vrij set for Lazio|
|BREAKING NEWS: Everton complete Besic signing|
|Kongolo pens Feyenoord extension|
|Redknapp confirms Granero exit|
|Advocaat confirmed as Serbia coach|
|CSL Preview: Henan aim to escape drop zone, Liaoning host Guangzhou RandF|
|Arribas makes Sevilla switch|
|Chambers joins Arsenal|
|Ospina buoyed by Arsenal recruitment|
|Liverpool´s loss is our gain, says Redknapp on Remy|
|Ferdinand: I would still be at United with Giggs in charge|
|Pepe targets Super Cup glory|
|Martinez prioritising striker signing|
|Perez not looking to leave Benfica|
|Klopp itching to work with full Dortmund squad|
|Mourinho: It feels like Drogba never left|
|FIFA asks for FIGC review into alleged racist remark|
|Hull to review Maguire deal|
|Wenger prepared to gamble on Chambers|
|Atletico agree Griezmann deal|
|Irvine planning further striker addition|
|Campbell: Black professionals scared to talk about racism|
|Mata backs Herrera to star in Premier League|
|Injured Rafael returning to Manchester|
|Schmidt demands more from Leverkusen|
|Copa Libertadores Preview: Defensor Sporting banking on home record|
|Remy´s Liverpool move off, confirms Rodgers|
|Inzaghi demands nastiness from Milan|
|MLS Review: Timbers triumph in Montreal, Dallas thwart Vancouver|
|Jovetic ready to lead City line - Pellegrini|
|Lewandowski impresses Ribery, Alaba|
|Colombian Primera A Review: Three clubs remain perfect, Atletico Nacional get off the mark|
|Rodgers: ´We can score goals´ without Suarez|
|Chilean Primera Division Review: Canales brace powers Universidad Chile|
|Atletico Madrid need penalties to edge past Earthquakes|
|Liga MX Review: Monterrey, America stay perfect|
|Paraguayan Primera Division Review: Capiata set pace|
|Brazilian Serie A Review: Cruzeiro win again, Kaka scores|
|Sterling goal sees Liverpool past Olympiacos|
|Peruvian Primera Division Review: Los Caimanes notch maiden win, Inti Gas claim top spot|
|CAF Champions League Review: Zamalek held, Vita Club leave it late|
|Jovetic at the double as Manchester City thrash Milan|
|Monk thrilled by Sigurdsson contribution|
|Lovren signs for Liverpool|
|Mourinho pleased with Olimpija test|
|Vertonghen eager to remain at Spurs|
|Sigurdsson marks Swansea return with a brace|
|Lewandowski, Rode help Bayern retain Telekom Cup|
|Immobile scores and suffers injury in Dortmund win|
|Costa scores on Chelsea debut|
|CAF Confederation Cup Review: Leopards de Dolisie 1 Real Bamako 2|
|Thai Premier League Review: Buriram pull clear, Police edge away from danger|
|Falcao nears Monaco return|
|CSL Review: Harbin Yiteng produce another upset, Evergrande stretch lead|
|Britton and Emnes to miss season-opener|
|Taylor-Fletcher strike sinks Everton|
|J.League Review: Chasing pack close on Urawa Reds, Tokushima Vortis secure rare win|
|Ancelotti expects fresh Bale to be even better|
|Simeone keen on Griezmann|
|Mazzarri refuses to set Inter targets|
|Lazio director targeted by fans|
|Dyche rules out Deeney move|
|Rummenigge: Bayern will never sack Guardiola|
|BREAKING NEWS: Arsenal to bring in Ospina|
|Pochettino quiet on Schneiderlin link|
|Vidic settling into Inter life|
|Van Gaal hints at Zaha United future|
|Di Maria will report for training - Ancelotti|
|Wilshere vows to answer critics|
|Rodgers expecting titles|
|Deila demands Celtic cutting edge|
|Rodgers: We won´t rush Lallana|
|Wenger: We have to be better against top-level teams|
|FIGC presidential candidate uses racist slur|
|MLS Review: Columbus claim second straight win, Toronto falter|
|Villa battle past Dynamo in Houston|
|United more efficient, says Garcia|
|Pedestrian Tottenham edge past Chicago Fire|
|Van Gaal bemoans display|
|CS Sfaxien 1 ES Tunis 0: Troussier era opens with a win|
|Icardi stars from the spot as Inter overcome Real Madrid|
|Arsenal upstaged by Red Bulls|
|Pre-Season Friendly Review: Rooney stars for United, Bayern reach Telekom final|
|In-form Rooney inspires Manchester United win|