Bayer Leverkusen will hope to continue their outstanding home record in the UEFA Champions League group stages against Manchester United.
Sami Hyypia's men welcome the Premier League champions to the BayArena on Wednesday for a crucial Group A clash, as they look for their ninth home win in a row in the initial stages of Europe's premier club competition - a result that would send them top of the pool.
With 10 wins from their first 13 matches, Leverkusen have made their best ever start to a Bundesliga season this term, but their 1-0 win over Hertha Berlin on Saturday was overshadowed by the injury suffered by winger Sidney Sam.
Sam has been in electric form for club and country this season, scoring 11 goals, but he lasted just four minutes against Hertha before being substituted with a thigh problem.
His absence is likely to give attacker Robbie Kruse - recently awarded the Professional Footballers Australia's Player of the Year gong for 2013 - a chance, with the other wing set to be filled by South Korea star Heung-Min Son.
Leverkusen lie second in the group, with seven points from four matches, and they have not lost since a 4-2 defeat at United on matchday one.
Included in Leverkusen's home winning streak in the group stages are triumphs over Real Madrid, Roma and Valencia, while they also came from behind to defeat 2011-12 champions Chelsea 2-1.
However, Hyypia will be without defender Roberto Hilbert (knee) and midfielder Stefan Reinartz (heel) for this game at the BayArena.
United have won their last three Champions League fixtures against Leverkusen, although they were knocked out on away goals by the Germans in the 2001-02 semi-finals.
They are unbeaten in their last 10 matches in all competitions, climbing to sixth in the Premier League after a poor start to the season.
New manager David Moyes has finally found his feet at Old Trafford, but they were denied on Sunday when Kim Bo-Kyung headed an injury-time equaliser to give Cardiff City a last-gasp 2-2 draw in South Wales.
Wayne Rooney scored twice in the previous fixture against Leverkusen, taking his Champions League tally to 29 goals and cementing his place as Britain's all-time leading scorer in the competition.
He will be hopeful of adding to that, but may be without strike partner Robin van Persie again after the Dutchman missed the match at Cardiff with toe and groin issues.
Midfield enforcer Marouane Fellaini is suspended for this match following his late red card against Real Sociedad on matchday four, but Moyes will hope defenders Nemanja Vidic (concussion) and Phil Jones (groin) can return.
Michael Carrick is a certain absentee with an Achilles injury, but forward Danny Welbeck came back from a knee injury when he came off the bench at Cardiff.
|Coach: S. Hyypiä|
for Heung-Min Son 70'
for S. Reinartz 70'
for L. Bender 81'
|Argentina 2 El Salvador 0: Mancuello nets debut goal in straightforward win|
|Kovac not satisfied despite Croatia victory|
|Netherlands 1 Turkey 1: Huntelaar spares Hiddink from historic home loss|
|Ghana 1 Senegal 2: Konate brace downs Black Stars|
|Bulgaria 2 Italy 2: Controversial debutant Eder rescues Conte´s men|
|Morocco 0 Uruguay 1: Cavani spot-kick seals win|
|Al Sadd say talks with Xavi ongoing|
|McClean slams Sunderland´s handling of poppy controversy|
|Ghana 1-2 Senegal: Black Stars continue Afcon hangover|
|Cheltenham player diagnosed with cancer|
|Palace takeover talk premature - Parish|
|Odegaard becomes Euro qualifiers´ youngest starter|
|Job not done yet, Bale warns Wales|
|Israel 0 Wales 3: Brilliant Bale bags brace as Wales go top|
|Dunga backs Neymar to overhaul Pele´s Brazil goal record|
|League Two Review: Hartlepool climb out of drop zone, Cheltenham go bottom|
|El Salvador 0-2 Argentina: Martino's men triumph without Messi|
|League One Review: Canavan leaves it late to deny County|
|Freddy Adu signs with 11th team in as many years|
|Besiktas deny Cech, Danny rumours|
|Puerto Rico v Canada: Haber targets more momentum|
|Miranda not contemplating Atletico exit|
|Austin relaxed over England prospects|
|Manchester United should sign Ibrahimovic - Schmeichel|
|Ibe eyes Liverpool run-in|
|Bertrand called up by England as withdrawal of four players confirmed|
|A-League Review: Risdon nets stunner, Germano tames Roar|
|Panama v Costa Rica: Unbeaten run a secondary concern for Wanchope|
|Italy coach Conte shaken after death threats - FIGC chief|
|Barca fears over Alba eased|
|Schweinsteiger to start Germany qualifier|
|Akinfeev thanks fans after flare incident|
|Injuries offer Kane chance of first England start|
|Russian Football Union to protest following Montenegro abandonment|
|October comeback the target for injured Foster|
|Van der Vaart looks set to leave Hamburg|
|Bale focused on Wales - Coleman|
|Kluivert helps Curacao to victory|
|Hamstrung Alba returns to Barcelona|
|Macedonia v Australia: Confident visitors eye victory|
|Akinfeev to return to Moscow with Russia squad|
|Brnovic: Montenegro have no chance of qualifying|
|Russia had to resume after Akinfeev incident - Capello|
|Terim: Robben absence important|
|Brazil - Chile Preview: Winning is 'our only option' - Dunga|
|France - Denmark Preview: Olsen hits out at 'disrespectful' hosts|
|Morata keen to keep working|
|Canada 1 Guatemala 0: Haber heads Floro´s men to win|
|Difficult to find a place for Kane in starting XI - Hodgson|
|Difficult to find a place for Kane in starting XI - Hodgson|
|Montenegro-Russia abandoned after scuffle|
|Euro 2016 Qualifying Review: Montenegro-Russia abandoned, Spain and England win|
|Accrington Stanley 0 Newport County 2: Visitors up to sixth|
|Kane delighted with ´dream´ start|
|England 4 Lithuania 0: Kane enjoys dream debut|
|Spain 1 Ukraine 0: Morata settles tight contest|
|Akinfeev struck by flare as Montenegro-Russia game suspended after 30 seconds|
|Brazil v Chile: Winning is ´our only option´ - Dunga|
|Northern Ireland v Finland: Controversial fixture met with religious protests|
|Scotland v Gibraltar: Wilson out to dent countrymen´s hopes|
|Republic of Ireland v Poland: Pressure is on, says O´Neill|
|Georgia v Germany: Schneider warns world champions|
|PSV agree permament Guardado deal|
|France v Denmark: Olsen hits out at training facilities|
|Pienaar to return to Everton training|
|Hughes eyes silverware at Stoke after signing new deal|
|Portugal v Serbia: Carvalho vows to attack|
|Dynamo Kiev stadium partially closed after racism probe|
|Hull City fined £30,000 for misconduct|
|Balotelli must work hard for Italy return – Bonucci|
|Marchisio suffers knee ligament injury|
|Hughes agrees new Stoke City deal until 2018|
|Martinez hopeful over injured Everton trio|
|South Korea 1-1 Uzbekistan: Kuziboyev's debut strike denies hosts|
|South Korea 1 Uzbekistan 1: Kuziboyev´s debut strike denies hosts|
|Japan 2 Tunisia 0: Kagawa and Honda shine as Halilhodzic starts with a win|
|South Africa v Nigeria: Mashaba wary of bitter opponents|
|Japan 2-0 Tunisia: Kagawa & Honda shine in Halilhodzic's first game|
|Parma captain Lucarelli welcomes FIGC reforms|
|South Africa - Nigeria Preview: Mashaba wary of bitter opponents|
|Di Francesco ignoring Milan rumours|
|Melbourne Victory 2 Central Coast Mariners 1: Finkler leads fightback|
|Bale would be ´perfect´ for United - Scholes|
|Badstuber and Bellarabi out of Georgia clash|
|Rooney KOs boxing celebration|
|Allen thrilled with Welsh ´hunger´|
|Kovacic to miss Euro 2016 qualifier|
|Costa Rica 0 Paraguay 0: Dour draw marks Diaz debut|
|Reid ruled out of South Korea friendly|
|Deschamps talks up France despite defeat|
|Rooney chasing England goalscoring record|
|Brazil ´superior´ admit French veterans|
|Reeves sidelined for Finland clash|
|Confidence critical for rampaging Brazil - Dunga|