Borussia Dortmund's poor run of form will give Napoli confidence ahead of their trip to Germany for Tuesday's UEFA Champions League clash.
Dortmund have lost three matches in a row – something that has not happened since February 2010 – and have slipped to third in the Bundesliga as a result.
A 1-0 home defeat to Arsenal in Group F was followed by 2-1 and 3-0 league losses to Wolfsburg and Bayern Munich in domestic action, leaving Jurgen Klopp's men off the pace in the German top flight and at risk of missing out on the last 16 in Europe's premier club competition.
Club captain Sebastian Kehl (ankle) and defender Lukasz Piszczek (hip and groin) were selected on the bench against Bayern but Dortmund continue to be plagued by injuries to key players.
First-choice centre-back pairing Neven Subotic and Mats Hummels are long-term absentees, while left-back Marcel Schmelzer (calf) and midfielder Ilkay Gundogan (back) are also absent.
Subotic is likely to miss the rest of the season after suffering knee ligament damage at Wolfsburg, while Hummels tore ligaments in his right heel when on international duty with Germany.
As a result, Klopp moved for free agent Manuel Friedrich, a former Germany international who left Bayer Leverkusen at the end of last season and made his debut in Saturday's loss to Bayern.
Dortmund – who sit third in Group F with two wins from four matches – will hope Robert Lewandowski breaks a five-match goal drought for club and country against Rafael Benitez's men.
The previous encounter between the two sides saw Napoli post a 2-1 home win thanks to strikes from Gonzalo Higuain and Lorenzo Insigne.
Successive Champions League triumphs against Marseille have Napoli well-placed to reach the round of 16, with nine points from their four matches.
They need just a draw in Germany to qualify from the group but head into the game on the back of two Serie A defeats on the bounce.
Marek Hamsik moved to equal fifth on the club's all-time appearances list after coming off the bench in Saturday's 1-0 home loss to Parma but he limped off just nine minutes later with a foot injury that rules him out of this encounter.
Defenders Camilo Zuniga and Giandomenico Mesto will also be sidelined for the visitors with knee injuries.
|Coach: J. Klopp|
for J. Błaszczykowski 68'
for M. Reus 81'
for R. Lewandowski 89'
|Lallana: I was trying too hard|
|Walker juggles music, football careers in Sweden|
|Song to face ´brother from another mother´ Fabregas|
|Adriano announces Le Havre deal|
|Pardew braced for Old Trafford test|
|Lescott unfazed by City reunion|
|Tskhadadze appointed Georgia coach|
|United to finish top three - Ferdinand|
|Allardyce: Stamford Bridge stalemate saved my job|
|Southampton need three January signings, says Watson|
|Liverpool can make Champions League, says fanzine editor|
|Walsh: Hull clash crucial for Leicester|
|Toure, Aubameyang and Enyeama make shortlist for African gong|
|Docherty backs Chelsea to win two-horse race|
|Liverpool could benefit from Hyypia influence - Scales|
|Saudi Arabia name Asian Cup squad|
|Forty-year-old Cahill no problem for Postecoglou|
|Wenger criticism baffles Redknapp|
|Leicester must strengthen in window - Walsh|
|United not title contenders - Docherty|
|Koeman: Southampton youngsters will get a chance|
|Dyche empathises with Liverpool striker crisis|
|Cagliari turn to Zola|
|Rooney thanks Van Gaal for Christmas break|
|Cruzeiro offer Paulinho Tottenham exit chance|
|Carlisle´s wife grateful to Burnley|
|Katebe called up to Zambia AFCON squad|
|Cape Verde name AFCON squad|
|Finke names much-changed Cameroon squad|
|Grant omits World Cup troublemakers for AFCON|
|Blackpool striker Ranger goes AWOL|
|Allardyce relishing Mourinho meeting|
|Ashley fails to increase Rangers stake|
|Crystal Palace v Southampton: Koeman calls for focus|
|Warnock targeting striker in January|
|Chelsea v West Ham: Adrian vows visitors will attack|
|Heskey signs short-term deal at Bolton|
|Everton v Stoke City: Martinez eyes strong form|
|Juninho defends David Luiz|
|Burnley v Liverpool: Dyche defends Rodgers ahead of Turf Moor test|
|Arsenal v QPR: Wenger eyes festive momentum|
|Liverpool are growing in confidence, says Rodgers|
|Redknapp: Austin future could depend on survival|
|Martinez wants Everton consistency|
|Barca want Neymar until 2020, says agent|
|Jones undeterred by pressure of Liverpool starting role|
|Allardyce ´knows how to beat managers´ - Carroll|
|Jones playing for a new contract|
|China select Evergrande spine for Asian Cup|
|A-League Preview: Koren tips City to build|
|Khedira keen to fight for Real spot|