An injury-hit Barcelona's 20-match unbeaten record this season will be tested at Ajax in Group H of the UEFA Champions League on Tuesday.
Barcelona have not lost a competitive match since manager Gerardo Martino took over, and with three wins and one draw in their four group matches, the Spanish champions only need to draw in Amsterdam to secure first place and a berth in the last 16.
They strolled to a 4-0 La Liga win over Granada on Saturday, with first-half penalties from Andres Iniesta and Cesc Fabregas setting them on their way.
Alexis Sanchez and Pedro wrapped up the points with strikes after the break as Barca remained top of the table.
It will be a slightly weakened side that makes the trip to the Dutch capital, though, with Lionel Messi (thigh) and goalkeeper Victor Valdes (calf) ruled out for the rest of the group stage.
Dani Alves sustained a calf injury on international duty and missed the win over Granada, left-back Jordi Alba (hamstring) has not played since September and midfielder Jonathan dos Santos (knee) could be out until April.
In addition, Isaac Cuenca has not played this season following knee surgery, Ibrahim Afellay is yet to return from a thigh operation and just to compound Barca's woes, Alexis is suspended.
The Chilean, who has scored 11 goals in his last 12 matches for club and country, has picked up three bookings in the group stages.
This fixture will be Barcelona's 250th in the history of the Champions League, while a draw would be their 100th in UEFA competition.
Barcelona - who have a pass completion rate of 87 per cent, the best in the competition - won the reverse fixture 4-0 at Camp Nou in September, with Messi scoring a hat-trick.
That defeat was Ajax's joint heaviest in the Champions League but they boosted spirits with a 1-0 home win over Celtic earlier this month that keeps their hopes of reaching the round of 16 alive.
Ajax have four points from as many matches and could go second if results go their way, but they could also be eliminated if they lose and Milan win at Celtic.
The Eredivisie champions, who have lost their last nine matches against Spanish opposition, climbed to second thanks to a 3-0 home win over Heracles on Saturday.
Niklas Moisander returned from a knee injury in that match but Kolbeinn Sigthorsson (ankle) and Siem de Jong (hamstring) missed out after picking up injuries on international duty.
Striker Bojan, who is on loan at Ajax from Barcelona, has not played since tearing his hamstring in September.
|2||R. van Rhijn||59'|
|Coach: F. de Boer|
for N. Boilesen 34'
for L. Schöne 51'
for D. Hoesen 84'
|Peseiro to leave Porto|
|France 3 Cameroon 2: Payet stunner snatches victory|
|Laxalt for Rodriguez in Uruguay´s Copa squad|
|Guingamp unveil Kombouare as new head coach|
|Real Madrid confirm Achilles problem for Navas|
|Wilmots´ woes worsen as Belgium lose Lombaerts, Boyata|
|Marotta: Juventus optimistic on Dani Alves deal|
|Berlusconi: I courted Guardiola at Barcelona|
|Berlusconi: Donnarumma not for sale, even for €80m|
|Ginola back at home following heart surgery|
|Departing City boss Pellegrini could quit management|
|Ayestaran prepared to fight to keep Gomes at Valencia|
|Sagna hopes to remain at City under Guardiola|
|France 3-2 Cameroon: Payet nets dramatic late winner for Euro 2016 hosts|
|Roma complete permanent Rudiger deal|
|Senderos left out of final Switzerland squad for Euro 2016|
|AFC Wimbledon 2 Plymouth Argyle 0: Dons reach the third tier|
|Spain v South Korea: Pedro wants goalscoring momentum|
|Reus demands Dortmund transfers|
|Poland v Netherlands: Lewandowski out to make the most of set pieces|
|Low still waiting on Germany fitness news|
|Juanfran promises Champions League success in heartfelt letter to fans|
|Skriniar joins Skrtel, Hamsik in Slovakia squad|
|Scholl: Gotze and Lewandowski dealings strange|
|Terry: Chelsea must learn from mistakes and fight for trophies again|
|Belgium v Finland: Hazard backs squad to cope without Kompany|
|Injury comeback on track, says Germany´s Khedira|
|Victor Sanchez sacked by Depor|
|Rashford signs Manchester United renewal|
|Sturridge resumes England training|
|Pellegrini rues decision to go public with Guardiola appointment|
|Luxembourg v Nigeria: Yusuf set for latest audition|
|Icardi, Perisic not for sale at any price - Inter|
|Carvajal to miss Euro 2016, replaced by Bellerin|
|Terry certain of Mourinho success at Manchester United|
|Pirlo not bitter towards Conte over Euro 2016 snub|
|Dortmund rule out Sokratis exit amid Atletico Madrid links|
|Barcelona revert to tradition with new kit|
|Robben and Ribery in line for Bayern renewals|
|King backs Wales to ´do a Leicester´ at Euro 2016|
|Deschamps: Zidane´s Champions League win is amazing|
|Pulido rescued by Mexican authorities|
|Alaves secure La Liga promotion|
|Gabriel´s childhood dream becomes a reality|
|Mexico v Chile: Vidal set for return|
|Boateng left ´sad´ after politician´s controversial comments|
|Mooy undecided on future|
|Gotze not concentrated on club future|
|Panama 0 Brazil 2: Jonas breaks goalscoring drought, Gabriel nets on debut|
|Postecoglou pleased with additions ahead of Greece clashes|
|Panama 0-2 Brazil: Jonas breaks goalscoring drought, Gabriel nets on debut|
|Ter Stegen laments ´unlucky´ error in Germany defeat|
|Santos hoping for Portugal improvement ahead of Euro 2016|
|Ronaldo dismisses critics after Champions League win|
|Uruguayan side complete Leicester-style championship win|
|New York City 2 Orlando City 2: Molino salvages late point|
|Colombia 3 Haiti 1: Cuadrado helps Pekerman´s side to win|
|Strachan hits out at wayward passing|
|Conte focusing on positives after Scotland victory|
|Colombia 3-1 Haiti: Cuadrado helps Pekerman's side to win|
|Portugal 3 Norway 0: Quaresma, Guerreiro light up Porto|
|Italy 1 Scotland 0: Pelle halts winless run|
|Bellerin in line to replace Carvajal - Del Bosque|
|Nolito dreaming of Euro 2016 after Spain double|
|Olympiacos striker Pulido kidnapped in Mexico - reports|
|Low concerned by Germany´s defensive performance|
|Portugal 3-0 Norway: No Ronaldo, no problem for dominant hosts|
|Deschamps will not consider Sakho recall|
|Germany 1 Slovakia 3: World champions continue to struggle|
|Italy 1-0 Scotland: Pelle strike settles tense friendly|
|Spain 3 Bosnia-Herzegovina 1: Nolito, Pedro on target|
|Martial set to miss France friendly through injury|
|Everton standards not what they should be - Coleman|
|Barnsley 3 Millwall 1: Hammill scorcher helps seal Championship return|
|Spain 3-1 Bosnia: Nolito fires La Roja to success|
|Emerson warns Morata against Real Madrid return|
|Germany 1-3 Slovakia: Hosts shocked in rain-affected friendly|
|Tiago has ´no doubt´ over Simeone´s Atletico future|
|Ben Arfa wants to match Messi, Ronaldo|
|Portugal v Norway Preview: Quaresma challenges hosts to prove Euro 2016 ambition|
|Republic of Ireland v Belarus: Coleman inspired by Leicester heroics|
|Bayern defend Boateng after politician´s insult|
|Too risky for England to start Stones at Euro 2016 - Campbell|
|Republic of Ireland v Belarus: Coleman inspired by Leicester heroics|
|Champions League Final: Could the Madrid derby rival El Clasico?|
|Mourinho gives Manchester United the X Factor they need, says Lampard|
|World Cup Qualifying Review: Tahiti thrash Samoa|
|Ballack: Schweinsteiger indispensable for Germany|
|Dortmund dismiss Aubameyang exit talk|
|Mourinho is really irritating, says Keane|
|Isco: I´ll stay if Real Madrid want me|
|Zieler close to Leicester move as Hannover confirm medical|
|Messi on the mend, say Argentina|
|´Deschamps should be flattered - Ryan Gosling is a Mormon´ – Cantona explains France boss criticism|
|Xhaka proud to complete ´dream´ Arsenal move|
|Conte concerned by De Rossi injury|
|Pepe hails Zidane influence after ´tough six months´ under Benitez|
|Hull City´s top-flight return comes at a cost for fans|
|Koeman: United don´t deserve FA Cup trophy after sacking Van Gaal|
|Ramos hails Zidane for turning Madrid around|
|Nobody expected this trophy – Arbeloa|
|MLS Review: Drogba scores late, Wright-Phillips nets treble|
|Benzema wants Madrid stay after Champions League win|
|Koke: I think Simeone will stay at Atletico|
|United States 4 Bolivia 0: Zardes scores brace as Pulisic opens account|
|Champions League final: A bomb scare, Clarence Seedorf and Ronaldo strips off again|
|United States 4-0 Bolivia: Zardes scores brace as Pulisic opens account|
|Saul: Atletico don´t deserve second heartbreak|
|Real Madrid players revel in Champions League success|
|Davies: Tottenham joked Pochettino was joining United|
|Gabi: I am convinced Atletico will win the Champions League|
|Mexico 1 Paraguay 0: Guardado extends unbeaten streak|
|Simeone to ´think about´ Atletico future|
|Zidane: I dreamed this would happen after getting Real Madrid job|
|Ronaldo ´had a vision´ he would score San Siro winner|
|James wants Real Madrid stay despite Champions League final snub|
|Real Madrid success an amazing journey, says Bale|
|Simeone rues Atletico ´failure´|
|Sterling tips Rashford for long England career|
|Navas hails Champions League triumph as ´dream come true´|
|Champions League trophy belongs to Real Madrid - Modric|
|Perez hails Zidane after dramatic Champions League win|
|Bale the main man for Madrid, and the rest of the Champions League final player ratings|
|Ronaldo: Real Madrid experience made the difference|
|Ronaldo gamble eventually pays off for Madrid|
|Griezmann´s penalty miss & Ronaldo´s nerves of steel - The key moments that decided the Champions Le|