Spain lost at the scene of their 2010 FIFA World Cup final triumph on Tuesday after a shock 1-0 defeat to South Africa.
Vicente del Bosque's men returned to Soccer City in Johannesburg for the first time since Spain beat Netherlands 1-0 in the final of the World Cup three years ago.
However, it proved a bittersweet occasion as striker Bernard Parker scored the only goal of the game in the friendly with a delicate finish after being played through by Thabo Matlaba.
There was late controversy, though, as Spain made a seventh substitution - the most permitted in a friendly is six - as goalkeeper Pepe Reina replaced the injured Victor Valdes nine minutes from time.
Germany claimed victory as rivalries with England were renewed, Per Mertesacker's second-half header inspiring the visitors to a 1-0 success as Joachim Low's men condemned the hosts to consecutive defeats at Wembley for the first time since 1977.
Netherlands extended their unbeaten run to 17 games with a 0-0 draw against Colombia, despite Jeremain Lens' dismissal in a bad-tempered affair at the Amsterdam Arena.
Belgium have been touted as outsiders for next year's FIFA World Cup, but they are still yet to beat Japan in their history after falling to a 3-2 home loss to Alberto Zaccheroni's men.
The hosts did take the lead through Kevin Mirallas before Yoichiro Kakitani's header and a strike from Keisuke Honda turned the game on its head.
Mainz attacker Shinji Okazaki added to Japan's lead and the visitors held on for a deserved win, despite Toby Alderweireld's late header.
Gibraltar marked their historic debut appearance on the international scene with a credible 0-0 draw with Slovakia.
Fyodor Smolov and Dmitriy Tarasov were on target as Russia came from behind to beat South Korea 2-1, while Marc Janko scored the only goal in Austria's 1-0 victory over United States.
Burak Yilmaz scored in the 89th minute to give Turkey a 2-1 win over Belarus and Republic of Ireland manager Martin O'Neill remains undefeated following his side's goalless stalemate with Poland.
Valter Birsa's second-half strike gave Slovenia a 1-0 win over Canada, while Scotland beat Norway by the same scoreline thanks to a deflected effort from Celtic midfielder Scott Brown.
Elsewhere, Malta overcame Faroe Islands 3-2, Liechtenstein lost 3-0 to Estonia and Kyrgyzstan drew 0-0 with Azerbaijan.
for D. Claasen 46'
for B. Khumalo 46'
for A. Jali 50'
for O. Manyisa 63'
for B. Parker 90+3'
|Kroos set for Real switch|
|MLS Preview: Sporting KC eye top spot, Red Bulls visit Union|
|Seattle Sounders 2 Portland Timbers 0: Conference leaders leave it late|
|2014 FIFA World Cup: Tweets of the tournament|
|2014 FIFA World Cup: Best goals|
|2014 FIFA World Cup: Tournament in numbers|
|2014 FIFA World Cup: Gotze glory rounds off captivating spectacle|
|2014 FIFA World Cup: To Russia with love?|
|World Cup win is unbelievable, says Gotze|
|Downing talks up Valencia arrival|
|Kramer: ´I can´t remember very much´|
|Peru Primera Division Review: Inti Gas go top, Universitario lose|
|Klose to decide on Germany future|
|Ecuador Primera A Review: Emelec poised for championship|
|Devastated Messi: Golden Ball not important|
|Messi comparison inspired Gotze, says Low|
|Hummels: I´m on another planet|
|Messi named player of the tournament|
|Sabella proud of players, defends Messi|
|Adebayor contracts malaria, out of US tour|
|Lahm ecstatic after World Cup triumph|
|Newcastle complete Cabella deal|
|Mascherano endures World Cup pain|
|2014 FIFA World Cup Final: Player Ratings|
|2014 FIFA World Cup Final: Where the final was won and lost|
|2014 FIFA World Cup Final: New Germany ready to dominate|
|2014 FIFA World Cup Final: Germany 1 Argentina 0 (after extra time)|
|BREAKING NEWS: Germany win World Cup|
|Rousseff thanks Brazil despite World Cup woe|
|Fred ´finished´ with Brazil|
|Manchester City lose to Dundee in pre-season opener|
|Rami keen to restore Milan glories|
|Thai Premier League Review: Muang Thong win again, BEC Tero Sasana pay penalty|
|In-demand Lovren joins Southampton on tour|
|Adidas to stick with Suarez|
|Cesar accepts Brazil career all but over|
|Rodriguez signs new Fiorentina deal|
|UEFA Champions League Preview: Celtic begin campaign, Steaua in Norway|
|K.League Review: Steelers maintain lead as top four all win|
|Suso eager for Liverpool stay|
|McDonald allays West Ham injury fears|
|Basanta urges Argentina to enjoy the moment|
|Schweinsteiger: Germany have big-match experience|
|Vidal relaxed over future|
|Bartomeu drooling over Barca strikeforce|
|Gerrard should remain captain, says Beckham|
|Cafu throws support behind Scolari|
|Sabella warns Argentina|
|MLS Review: Henry, Defoe star, as late goals rain down|
|Klinsmann: Germany are favourites|
|Robben rejects Van Gaal´s United proposal|
|Blind hopes Dutch youngsters stick together|
|Thiago Silva frustrated by failure|
|Adrian leaves Atletico for Porto|
|Van Gaal proud after Dutch win|
|Scolari leaving future up to CBF|
|Mixed emotions for Robben|
|FIFA World Cup: Brazil 0 Netherlands 3|
|Sabella remains unsure of Di Maria fitness|
|Abdennour pleased with friendly workout|
|Halilhodzic to take charge at Trabzonspor|
|Fenerbahce delighted to finally sign Diego|
|Low and Germany ready for finale|
|Lyon agree Rose deal|
|Neymar´s World Cup delights Bartomeu|
|De Laurentiis: Higuain going nowhere|
|Beckham lauds ´amazing´ Messi|
|PSG beat Videoton in seven-goal thriller|
|Horta makes Malaga switch|
|Southampton seal deal for Pelle|
|Barcelona ´convinced´ of reduction in Suarez ban|
|West Ham held by League Two Stevenage|
|Bianchi makes move to England|
|West Ham must be more clinical, says Allardyce|
|Germany experience will count - Lehmann|
|Berahino and Dorrans strike in Albion win|
|Ince settling quickly at Hull|
|Swansea in talks with Napoli over Michu|
|Dodo eyes Champions League with Inter|
|FIFA World Cup Preview: Germany v Argentina|
|Huddlestone out to hit the ground running|
|Pogba not bound for Chelsea - agent|
|Barry feeling fresh with Everton|
|Arteta plays down transfer talk|
|PSV complete De Jong deal|
|Colback excited for busy pre-season|
|Milan and Orlando in talks over Robinho|
|West Brom bring in Pocognoli|
|Maradona: Messi will define World Cup final|
|Rami seals Milan move|
|Kuyt eager to secure third place|
|Rodriguez talks up Real Madrid move|
|Bebe welcomes Benfica link|
|Koeman admits unsettled Lovren could leave|
|FIFA World Cup Final Preview: Argentina face old foes Germany with Brazil´s party in tatters|
|FIFA World Cup Final Preview: Messi aims to cement legacy|
|FIFA World Cup Final Preview: Sabella on the brink of greatness|
|FIFA World Cup Final Preview: Muller seeks to augment outstanding finals record|
|FIFA World Cup Final Preview: Low´s hard work pays off|
|FIFA World Cup Final Preview: The coaches to have tasted glory|
|FIFA World Cup Final Preview: The five most iconic finals|
|FIFA World Cup Final Preview: The five most iconic finals|
|FIFA World Cup Final Preview: Germany´s route to the final|
|FIFA World Cup Final Preview: Brazil 2014 produces moments to remember|
|SJ Earthquakes 1 DC United 2: Johnson, Silva score as Eastern Conference leaders extend advantage|
|Otamendi unfazed by price tag|
|Sam targeting top three with Schalke|
|Rodriguez out for revenge|
|Bruno Alves could leave Fenerbahce|
|Thiago Silva endured sleepless nights|
|Final on enemy soil ´special´, says Zabaleta|
|Arteta: Sanchez signing highlights Arsenal´s ambition|
|Mertesacker demands repeat performance|
|Scolari gets federation backing|
|Balotelli poses with shotgun|
|Lizarazu lauds Argentina´s craftiness|