Nacional regained second spot in the Uruguay Primera Division after they snapped a losing streak at Cerro Largo, while River Plate drew.
Ivan Alonso scored a hat-trick for Rodolfo Arruabarrena's men, in what was a spiteful clash at Cerro's Estadio Municipal Arquitecto Antonio Eleuterio Ubilla.
Alonso opened his account for the match on the half-hour mark and doubled it 11 minutes later as the visitors to Melo led 2-0 at the break.
Enzo Borges got the home side on the board five minutes after the restart, but any hope of a comeback was swiftly ruled out seven minutes later when Alonso wrapped up his hat-trick to move to nine goals for the season - taking him second in the golden boot race.
Cerro Largo then went haywire as Guillermo Moretti and Alejandro Acosta were both dismissed in the final 26 minutes, while Nacional also lost a man - Juan Diaz - after he received two cautions.
Substitute Alexander Medina added Nacional's fourth goal in the dying stages, as they moved to 24 points - two behind league leaders Danubio, and one ahead of third-placed River Plate.
River Plate coughed up a two-goal lead late at home to Sud America, as they were kept to a 2-2 draw.
Sud America continued their unbeaten run in stunning fashion, going undefeated in four games after Angel Luna and Adrian Argacha both struck in the final three minutes to deny the hosts in Montevideo.
Earlier, Michael Santos and Alexander Rosso scored three minutes apart to fire River Plate to a comfortable lead just prior to the half-hour mark.
But they would not be able to make it consecutive victories, as they fell three points behind Danubio.
The league leaders dealt with a struggling Racing 2-0 at the Parque Osvaldo Roberto in the nation's capital, as Jonatan Alvez and Liber Quinones scored second-half goals.
El Tanque Sisley bounced back from their last-start home loss to Cerro with a 1-0 win on the road at Defensor Sporting.
Santiago Lamanna scored the winner for El Tanque Sisley, who kept a clean sheet against a Defensor side that put five goals past Nacional last time out.
Liverpool continued their unbeaten streak, making it seven games without defeat after fighting back twice to earn a 2-2 draw at home to Juventud de Las Piedras.
Facundo Barcelo converted from the spot both times for Liverpool - with the latter coming in the 84th minute to equalise for the second time.
Wanderers made it three straight victories with a 1-0 result over Rentistas - which took the winners to sixth on the table with 17 points.
Penarol picked up their second win in three outings with a 2-1 home success over Fenix, while Miramar Misiones broke their duck this season with a 2-1 road win over Cerro.
Miramar Misiones remain rooted to the foot of the table with seven points from 11 matches, with Juventud and Fenix (both eight) now in their sights.
|G. Moretti||21' 64'|
|Coach: J. Rodríguez|
for H. Fener 50'
for J. Blanco 61'
for R. Echandía 68'
|Mourinho can match Guardiola, insists Ferguson|
|Ferguson hails Klopp: Liverpool are strong title contenders now|
|Bayern optimistic over Lewandowski renewal|
|Zubizarreta appointment confirmed by Marseille|
|Clichy: Things will click into place for Manchester City|
|Chiellini: Juventus wanted to send a message|
|Gabigol´s time will come - De Boer|
|Ronaldo: Messi and I are not friends - but we respect each other|
|Earthquake halts play in Serie A game between Pescara and Atalanta|
|Mourinho charged over Taylor comments|
|Ronaldo: I need my haters|
|Badstuber hopeful injury woes behind him|
|Kroos did not want to be rested, insists Zidane|
|Rojo was phenomenal - Mourinho|
|Seven arrests made after West Ham - Chelsea fan clashes|
|Florenzi injury blow for Roma|
|MLS Review: Galaxy, Toronto into semis|
|Beister: Victory move surprised people|
|Bilic: Cup run will help in Premier League|
|Pjaca out for up to three weeks|
|Trophies still the focus for Guardiola|
|Mignolet wants ´fair´ Karius battle|
|Ancelotti impressed by motivated Bayern|
|West Ham ´unreservedly condemn´ crowd trouble|
|Allegri praises strike duo after win over Sampdoria|
|De Boer praises two-goal Icardi after vital win|
|Chelsea were ´unlucky´ with missed chances, insists Conte|
|Mourinho: I´ve never had fans like these|
|Nacho´s goal better than my Champions League final volley - Zidane|
|Borussia Dortmund 1 Union Berlin 1 (aet, 3-0 pens): Weidenfeller shootout heroics seal progress|
|Bilic: Crowd trouble distracts from great West Ham win|
|Kompany told me he couldn´t play anymore - Guardiola|
|Liverpool and Manchester United handed home quarter-finals|
|Inter 2 Torino 1: Icardi double alleviates pressure on De Boer|
|Manchester United 1 Manchester City 0: Mata extends Guardiola´s winless run|
|West Ham 2 Chelsea 1: Crowd trouble tarnishes Hammers´ route to quarter-finals|
|Cultural Leonesa 1 Real Madrid 7: Morata and Asensio star in BBC´s absence|
|Bayern Munich 3 Augsburg 1: Green´s first goal sends holders through|
|Juventus 4 Sampdoria 1: Rapid start sets champions on their way|
|Crafty Suarez is world´s best striker - Godin|
|Mancini: Balotelli has wasted years but can bounce back|
|Rami rejected ´risky´ PSG move|
|Neymar would have cost PSG €430m, claims father|
|Sacchi warns Bayern players over Ancelotti temper|
|Valencia ´pleased´ with RFEF bottle ruling|
|Mourinho apologises to Utd fans for Chelsea thrashing|
|Barcelona lash out at ´totally reprehensible´ RFEF comments|
|Jacob leaves Marseille amid rumours of Zubizarreta appointment|
|Lavezzi added to Argentina squad as Dybala drops out|
|Del Bosque: Mourinho had a point on Conte|
|N´Zonzi in talks over Sevilla extension|
|Allardyce successor ´will not be a mercenary´ - Glenn|
|Aubameyang like a rocket, Lewandowski perfect - Riedle|
|RFEF fines Valencia, warns Barca over bottle incident|
|Wenger tells Iwobi to improve his finishing|
|Barcelona without Mathieu for three weeks|
|Kimmich draws inspiration from Xavi|
|Vazquez signs new Madrid deal|
|Higuain the best striker in the world - Nedved|
|Wolfsburg regret De Bruyne, Perisic sales|
|Parejo slams Neymar for ´inciting´ Valencia fans|
|Gundogan predicts ´very lively´ Manchester derby|
|Luis Enrique satisfied with Supercopa workout|
|Messi could join Newell´s after World Cup - Maxi Rodriguez|
|Ibrahimovic wants United to be the boss of City|
|Schmidt on the bus as Lotte book ticket for next round|
|Pogba still adapting to Premier League, says Mourinho|
|Southgate hails influence of demoted Rooney|
|Lille ready to heap more pressure on PSG as Corchia dreams big|
|I´m among top 20 LaLiga coaches, jokes Luis Enrique|
|Brattan earns Socceroos call-up|
|Pochettino pleased with Janssen|
|Klopp never questioned Sturridge quality|
|Barcelona downed by Espanyol in Supercopa|
|Heavy Milan defeat ´just a bump in the road´ - Montella|
|Pochettino wanted Liverpool debutant sent off|
|Klopp happy to entertain as Liverpool youngsters earn their spurs|
|Leverkusen dumped out by 10-man minnows|
|Wenger praises Oxlade-Chamberlain work ethic|
|Wenger praises Oxlade-Chamberlain work ethic|
|Tuchel unaffected by Real Madrid rumours|
|I would like to pick Toure, believe me - Guardiola|
|Genoa 3 AC Milan 0: Unbeaten run comes crashing to an end as Paletta sees red|
|Liverpool 2 Tottenham 1: Sturridge at the double to book quarter-final spot|
|Arsenal 2 Reading 0: Oxlade-Chamberlain brace secures safe passage|
|Football world mourns Carlos Alberto|
|81 per cent win ratio and more goals than Bayern Munich - Two years of Messi, Suarez and Neymar|
|Ridgewell reportedly arrested for drink driving|
|Verratti not leaving PSG - agent|
|Costa competition benefitting Batshuayi, says Conte|
|Pele hails ´friend and brother´ Carlos Alberto|
|Bailly confirms two-month lay-off|
|How Carlos Alberto established his legacy as one of the greats|
|Allegri hints at Marchisio return|
|Lewandowski has not renewed with Bayern - agent|
|Carlos Alberto: Capita´s World Cup triumph in numbers|
|Hull´s Snodgrass out for a month|
|Keita reveals Arsenal, Manchester City, Liverpool snub|
|Mikel not giving up on Chelsea career|
|Former Brazil captain Carlos Alberto dies|
|Guardiola wants to help ´special player´ Aguero|
|Roma welcome back Strootman, Rudiger for Sassuolo clash|
|Wolves confirm Zenga dismissal|
|Bruce lauds Rooney as a world ´great´|
|Raiola made €27m on Pogba move, reveals Juventus director|
|Dortmund injury woes worsen with Aubameyang|
|De Bruyne out of Manchester derby|
|Conte: I always show respect to opponents|
|FIFA fines RFEF over Madrid, Atletico breaches|
|Pedro backs Conte amid Mourinho spat|
|Big clubs would fight for Edwards if he was Brazilian - Pochettino|
|They boo Ronaldo, they booed me as well - Zidane|
|De Boer fed up of sacking talk|
|Neuer: Bayern have no room for error|
|Bilic praises Conte´s ´aggressive´ demeanour|
|Di Maria will bounce back - Motta|
|EFL opens investigation into Watford over ´forged´ bank letter|
|Hummels admits RB Leipzig a serious threat for Bayern|
|Pedro reveals Barcelona talks|
|De Bruyne: I have no problem with Mourinho|
|Casillas: I have not retired from Spain duty|
|Raul backs under-fire Ronaldo for Ballon d´Or glory|
|Mourinho and United must lower expectations - Xavi|
|Hands off! Milan CEO insists Donnarumma will stay|
|Glory coach Lowe accepts ban|
|Scolari extends contract with Guangzhou Evergrande|
|Guardiola eliminated City doubts - De Bruyne|
|Klopp lauds Ings for ´perfect´ response|
|Wenger: Perez needs to take chance|
|Boys to men: Mourinho challenges United players|
|Kompany committed to bargain with City medics|
|´Insipid´ Hazard overlooked for Ballon d´Or|