Nacional regained second spot in the Uruguay Primera Division after they snapped a losing streak at Cerro Largo, while River Plate drew.
Ivan Alonso scored a hat-trick for Rodolfo Arruabarrena's men, in what was a spiteful clash at Cerro's Estadio Municipal Arquitecto Antonio Eleuterio Ubilla.
Alonso opened his account for the match on the half-hour mark and doubled it 11 minutes later as the visitors to Melo led 2-0 at the break.
Enzo Borges got the home side on the board five minutes after the restart, but any hope of a comeback was swiftly ruled out seven minutes later when Alonso wrapped up his hat-trick to move to nine goals for the season - taking him second in the golden boot race.
Cerro Largo then went haywire as Guillermo Moretti and Alejandro Acosta were both dismissed in the final 26 minutes, while Nacional also lost a man - Juan Diaz - after he received two cautions.
Substitute Alexander Medina added Nacional's fourth goal in the dying stages, as they moved to 24 points - two behind league leaders Danubio, and one ahead of third-placed River Plate.
River Plate coughed up a two-goal lead late at home to Sud America, as they were kept to a 2-2 draw.
Sud America continued their unbeaten run in stunning fashion, going undefeated in four games after Angel Luna and Adrian Argacha both struck in the final three minutes to deny the hosts in Montevideo.
Earlier, Michael Santos and Alexander Rosso scored three minutes apart to fire River Plate to a comfortable lead just prior to the half-hour mark.
But they would not be able to make it consecutive victories, as they fell three points behind Danubio.
The league leaders dealt with a struggling Racing 2-0 at the Parque Osvaldo Roberto in the nation's capital, as Jonatan Alvez and Liber Quinones scored second-half goals.
El Tanque Sisley bounced back from their last-start home loss to Cerro with a 1-0 win on the road at Defensor Sporting.
Santiago Lamanna scored the winner for El Tanque Sisley, who kept a clean sheet against a Defensor side that put five goals past Nacional last time out.
Liverpool continued their unbeaten streak, making it seven games without defeat after fighting back twice to earn a 2-2 draw at home to Juventud de Las Piedras.
Facundo Barcelo converted from the spot both times for Liverpool - with the latter coming in the 84th minute to equalise for the second time.
Wanderers made it three straight victories with a 1-0 result over Rentistas - which took the winners to sixth on the table with 17 points.
Penarol picked up their second win in three outings with a 2-1 home success over Fenix, while Miramar Misiones broke their duck this season with a 2-1 road win over Cerro.
Miramar Misiones remain rooted to the foot of the table with seven points from 11 matches, with Juventud and Fenix (both eight) now in their sights.
|G. Moretti||21' 64'|
|Coach: J. Rodríguez|
for H. Fener 50'
for J. Blanco 61'
for R. Echandía 68'
|Gardner calls for fans´ support|
|Zidane: Benzema must score|
|Scholes: Liverpool are Champions League dark horses|
|Gerrard hopes for prolific Balotelli|
|Gervinho pens new Roma deal|
|Rodgers praises vice-captain Henderson|
|Argentine Primera Division Review: Independiente goalkeeper bags brace|
|Costa Rican Primera Division Review: Cartagines back to winning ways|
|Ronaldo to United a possibility, says Neville|
|Liga del Futbol Profesional Boliviano Review: Bolivar go top, Blooming slip up|
|Souness throws support behind Pardew|
|Allardyce targets defensive improvement|
|Bruce: Hernandez worth the wait|
|Ecuadorian Primera A Review: Barcelona win El Clasico del Astillero|
|Davies: Draw a fair result|
|Noble rues West Ham´s close shave|
|Klopp cautious with Kagawa|
|Eibar 0 Deportivo La Coruna 1: Dominguez earns Fernandez first win|
|Hull City 2 West Ham 2: Debutants star in KC drama|
|Verona 2 Palermo 1: Pisano own goal seals home win|
|Turkish Super Lig Review: Fener, Gala and Besiktas all held|
|Roma v CSKA Moscow: Garcia ready to recall attacking stars|
|Van Basten to return to AZ following leave of absence|
|Olympiacos will be toughest tie - Simeone|
|Porto v BATE: Sandro in line for return as Porto seek strong start|
|Calhanoglu pledges to attack off-colour Monaco|
|Malmo have advantage over Juventus - Hareide|
|Chambers´ tonsillitis adds to Arsenal defensive woes|
|Hasi: No expectations for Anderlecht|
|Verratti extends PSG contract|
|Bayern Munich v Manchester City: Kompany urges belief|
|Prandelli calls on fans to voice their backing|
|Michel wary of Atletico prowess|
|Double fitness boost for Everton|
|Barcelona v APOEL: Pedro expecting tough test|
|Vidal and Pirlo to miss Malmo clash|
|Maribor v Sporting Lisbon: Slovenians end 15-year wait|
|Athletic Bilbao v Shakhtar Donetsk: Muniain eyes home comforts|
|Rodgers ready to embrace Champions League challenge|
|Milan confirm injuries to Lopez and Alex|
|Ajax v Paris Saint-Germain: Away form not a concern, says Van der Wiel|
|Experience the key for Monaco boss Jardim|
|Anelka joins Mumbai|
|Chelsea v Schalke: Costa aims to maintain prolific form|
|Ancelotti seeks response against Basel|
|Zaha not giving up on United and England future|
|Garcia to miss Blackpool game with chest pains|
|Lambert keen to keep Villa grounded|
|Adebayor wants ruthless streak|
|Lahm not missing Kroos|
|Begovic unconcerned by Stoke inconsistency|
|United duo lavish praise on Di Maria|
|Rami targets starting berth|
|Wilshere prefers advanced role|
|Calderon: Ronaldo disillusioned at Real|
|Ferdinand: Moyes´ tactics were embarrassing|
|I never meant to disrespect Southampton - Schneiderlin|
|I never meant to disrespect Southampton - Schneiderlin|
|Howard: Lukaku wants to be world´s best|
|Bielsa remaining tight-lipped over Labrune talks|
|Mourinho salutes Costa character|
|Bruce makes plea to Hull fans|
|Foster slams ´pathetic´ Brunt abuse|
|Donadoni rues errors in Milan loss|
|Seoul v Western Sydney Wanderers: A-League side eye away win|
|Colombian Primera A Review: Once Caldas go top|
|Venezuelan Primera Division Review: Deportivo Tachira continue unbeaten run|
|Copa Sudamericana Preview: Boca Juniors, River Plate hold narrow leads|
|Uruguayan Primera Division Review: Racing go clear at top|
|Chilean Primera Division Review: President, coach clash doesn´t derail Colo Colo|
|Peruvian Primera Division Review: Melgar, Universitario remain undefeated|
|Brazilian Serie A Review: Sao Paulo beat leaders|
|Paraguayan Division Profesional Review: Nacional Asuncion win again|
|San Jose Earthquakes 1 Los Angeles Galaxy 1: Keane´s penalty miss proves costly|
|Milan progression encourages Inzaghi|
|Ligue 1 Review: Marseille revival continues as Lille stay unbeaten|
|La Liga Review: Valencia continue resurgence, Sevilla ignore goalkeeper crisis|
|Menez thrilled with Milan victory|
|Primeira Liga Review: Porto held at Guimaraes, Boavista claim first win|
|Serie A Review: Goals flow as Inter and Milan both win|
|Parma 4 Milan 5: Visitors triumph in nine-goal thriller|
|Galatasaray v Anderlecht: Unfancied pair meet in Turkey|
|Di Francesco: I would have gladly made 11 changes|
|Liga MX Review: America held by strugglers Universidad, Santos close in on leaders|
|Van Gaal focused on United trajectory|
|Borussia Dortmund v Arsenal: Familiar opponents renew rivalry|
|Championship Preview: Adams talks up Norwich, Wolves head to unbeaten Charlton|
|Bundesliga Review: Hamburg beaten again, Augsburg claim first points|
|Eredivisie Review: Cambuur humble rivals Groningen, Vitesse finally win|
|League Two Preview: Flitcroft urges Bury caution, Burton out to extend lead|
|Benfica v Zenit St. Petersburg: Battle of the high-fliers|
|Redknapp expected heavy United defeat|
|United can do much better, says Van Gaal|
|Benitez at a loss to explain Napoli defeat|
|Manchester United 4 QPR 0: Di Maria steals show on Falcao debut|
|League One Preview: Cotterill demands focus, Dickov bids to ease pressure|
|Monaco v Bayer Leverkusen: Hosts eye positive amid awful start|
|Mazzarri praises ´ideal´ Inter|
|Al Qadsia v Persipura: Kuwaitis seek place in third final|
|Liverpool v Ludogorets: Five-time winners back in the Champions League|
|Real Madrid v Basel: Break from La Liga woes for Ancelotti´s men|
|Inter 7 Sassuolo 0: Icardi hits hat-trick in rout|
|Nottingham Forest 1 Derby County 1: Scrambled equaliser earns visitors a point|
|CSL Review: Henan drop into bottom two after last-gasp equaliser|
|Juventus v Malmo: Allegri´s men aiming to crack Europe|
|Olympiacos v Atletico Madrid: Simeone´s men on crest of a wave|
|K. League Review: Top two earn narrow victories, Sangju Sangmu end winless run|
|Badstuber requires surgery on thigh injury|
|Godin: Our mentality remains|
|Bruce slams ´disrespectful´ Newcastle speculation|
|Pogba confirms Juve talks|
|Gotze expecting improvement at Bayern|
|Mancini interested in Portugal role|
|I was never close to United move - Muller|
|Welbeck impresses Wenger with debut display|
|Mourinho wary of Euro group rivals|
|Rio Ferdinand will never forgive ´biggest idiot´ Terry|
|MLS Review: New England win again, New York held|
|Erbil v Kitchee: Belencoso the key for Molina´s men|
|Al Hilal v Al Ain: Dalic happy with preparation|
|CONCACAF Champions League Preview: In-form Red Bulls travel to Canada|
|Casillas accepts fans´ criticism|
|Primeira Liga Review: Sporting held again, Rio Ave back to summit|
|La Liga Review: Atletico claim bragging rights, Neymar inspires Barca|