Germany head to San Siro on Friday hoping to bring an end to their dismal recent record against Italy.
The Germans - who will be managed by Joachim Low for the 100th time - last tasted victory in this fixture back in 1995 and have since gone on to draw two and lose four of the subsequent six fixtures, only one of which was played in Italy.
Furthermore, Germany have never beaten Italy at a major tournament, and continued that trend at Euro 2012, when the Azzurri recorded a 2-1 semi-final victory.
Italy were also responsible for Germany's last-four exit from the 2006 FIFA World Cup - winning 2-0 after extra time before going on to lift the trophy.
The statistics are made all the more remarkable by the fact that Germany currently sit second in the world rankings - six places above their opponents this week.
But centurion Low - who has led Germany to the final of Euro 2008 as well as the last four of the 2010 World Cup and Euro 2012 - hopes facing his country's bogey team will prove to be the perfect preparation for the 2014 World Cup, a tournament both teams reached by winning their qualifying groups.
"Italy are tactically world class, and the national team still plays at a high level," he said. "The Italians are characterised by their cleverness and efficiency.
"To play against this team was our desire, because we can only evolve if we face strong opponents."
Italy coach Cesare Prandelli, meanwhile, believes his side's friendlies against Germany and Nigeria next week can help narrow down his squad for next year's tournament.
"There are places available," he said. "Many players are motivated, they want to prove that they can be a part of such a group. I have in my mind 35 players so nothing is definite.
"I have a precise idea of what type of football I want the team to play.
"Seeing as I am not able to work with the team a lot on the pitch, I've had to use official games to understand this. During the games, there will be various interpretations but our reference module will be that of four midfielders."
|Coach: C. Prandelli|
for P. Osvaldo 53'
for A. Barzagli 71'
for A. Pirlo 82'
|West Ham 3 Lusitans 0: Sakho nets twice at start of Europa League journey|
|Holebas makes Watford move|
|Milan secure Adriano signing|
|Peru v Paraguay: Diaz counts cost of semi-final loss|
|Bastia hit out at reports of extra debt|
|Hernandez has successful surgery|
|Odemwingie signs one-year Stoke extension|
|Uth signs for Hoffenheim|
|Henen seals Everton return|
|Cattermole pens long-term Sunderland deal|
|United States v Guatemala: Klinsmann backs Dempsey ahead of Gold Cup warm-up|
|West Ham working on Jenkinson return - Gold|
|Milan agree deal for Bacca|
|Real buy back Vazquez from Espanyol|
|Richards leaves Swansea for Fulham|
|McShane signs for Reading|
|Giggs tells youngsters to seize US chance|
|Hammond pens Leicester extension|
|Only Schweinsteiger can decide Bayern future - Guardiola|
|Cech plans to play until he´s 40|
|Montoya arrives in Milan ahead of Inter move|
|Hernandez out of Gold Cup|
|US asks Switzerland to extradite seven FIFA officials|
|MLS Preview: Sounders seek momentum switch|
|Mexico 0 Honduras 0: Hernandez injury sours friendly|
|Hernandez taken to hospital|
|Garay in doubt for Copa America final|
|Wambach: USA peaking for World Cup final|
|Bassett ´an absolute hero´ despite own goal - Sampson|
|Japan 2 England 1: Late own goal breaks English hearts|
|Salvo quits as Valencia president|
|Costa not Ribery cover - Bayern director Sammer|
|Chile, Argentina deserve final spots - Mena|
|Ramos keen on United switch - Calderon|
|B36 1 The New Saints 2: Wilde leaves it late to secure advantage|
|Sevilla agree deal for Rami|
|Celtic snap up United teenager Janko|
|Beauvue passes Lyon medical|
|Roma bring in Falque|
|Coates completes permanent Sunderland switch|
|Vallecano to make charity donations from shirt sales|
|Angella commits to Watford|
|Gundogan pens new Dortmund deal|
|Juve reject €80million Barca offer for Pogba, says Marotta|
|Ruiz seals permanent Villarreal move|
|Mourinho respects Cech´s decision to quit Chelsea|
|Claridge excited by potential Pearson successors|
|Miranda completes Inter switch|
|Blind takes over as Netherlands coach|
|Mourinho: Premier League tougher to win than ever|
|Hamburg make Holtby move permanent|
|Southampton terminate Osvaldo contract|
|BREAKING NEWS: Swansea swoop for Eder|
|Abbiati extends Milan stay|
|Cruyff: Barcelona have lost their values|
|Vydra seals Watford move|
|Ambitious Clyne targets trophy haul with Liverpool|
|Claridge: Off-field incidents cost Pearson his job|
|Clyne becomes Liverpool´s sixth close-season signing|
|Imbula leaves Marseille for Porto|
|FIFA chief Blatter challenges critics to prove corruption claims|
|Distin joins Bournemouth|
|Bayern seal Costa deal|
|Arsenal confirm Diaby departure|
|Blatter to miss Women´s World Cup final|
|Bogdan sets sights on being Liverpool number one|
|Danilo eager to get started at Real Madrid|
|Leicester´s Wood joins Leeds|
|Porto confirm Atletico move for Martinez|
|Lloyd: Repetition key to netting penalty|
|Sheffield Wednesday job a ´dream´ for Carvalhal|
|´We played a complete game´ - Messi|
|Diaz upbeat despite heavy Copa loss to Argentina|
|Martino lauds Messi for selfless performance|
|Viviani makes surprise Verona switch|
|Estonian team wins cup match 31-0|
|No meeting with Arsenal has occurred - Vidal´s agent|
|United States 2 Germany 0: Ellis´ team reach World Cup final|
|Argentina 6 Paraguay 1: Messi leads Martino´s men to Copa final|
|UEFA Europa League Review: FK Zeljeznicar and FC Dacia Chisinau open with wins|
|UEFA Champions League Review: FC Pyunik make winning start|