Arsenal face a stern test of their title credentials as they target their first away win over Manchester United in seven years.
Arsene Wenger's men claimed a five-point lead at the Premier League's summit after the 2-0 home victory over Liverpool, but a trip to Old Trafford arguably represents a greater threat to their supremacy.
Not since September 2006 have Arsenal come away from United with a win - a nine-match run across all competitions - as Emmanuel Adebayor netted the winner on that occasion.
The nadir came in 2011, when the hosts dished out an 8-2 top-flight drubbing to their shell-shocked visitors.
But Wenger's charges are made of tougher stuff this season and will take huge confidence from their excellent 1-0 victory against Borussia Dortmund in the UEFA Champions League in midweek.
If Arsenal can claim a maximum haul on Sunday, they will open up an 11-point gap over the defending champions.
Part of their success has been down to the form of midfielder Aaron Ramsey, who has contributed six goals and three assists in his last seven Premier League appearances.
"I think I have shown how much I rate him in the past," Wenger said. "When he was hugely criticised I always played him. That shows you how much I admire him and how much I think he is a great player."
Wenger expects to welcome Mathieu Flamini back from a groin injury, but Jack Wilshere (ankle) is not likely to feature.
Long-term absentees Theo Walcott (pelvis), Lukas Podolski (hamstring), Alex Oxlade-Chamberlain and Abou Diaby (both knee) remain sidelined.
United have endured an inconsistent start to the campaign, but three wins from their last four league matches have propelled Moyes' men into top-four contention.
Their latest triumph came in a 3-1 victory at Fulham on Saturday, with first-half strikes from Antonio Valencia, Robin van Persie and Wayne Rooney doing the damage.
Rooney will be particularly confident ahead of the match. He has notched 10 top-flight goals against Arsenal, including his first league effort, first for United and his 100th Premier League strike.
Moyes, whose side are unbeaten in eight matches in all competitions, will hope to have Michael Carrick (Achilles) available, while Jonny Evans should shake off a back complaint. Striker Danny Welbeck will not be in contention as he continues his recovery from a knee injury.
|20||R. van Persie||27'|
|Coach: D. Moyes|
for N. Vidić 46'
for S. Kagawa 78'
for R. van Persie 85'
|Newcastle stay perfect in NZ|
|Van Gaal prepared to wait for Strootman|
|West Brom overcome Sacramento|
|Colorado Rapids 3 Chivas USA 0: Hosts rise to third in the West|
|Gameiro brace adds to West Ham woes|
|Villas-Boas: Rodriguez best suited to no.10 role|
|Cazorla: I´m happy at Arsenal|
|Reina respects Liverpool contract|
|Lampard could move to Melbourne on loan|
|Galliani: Balotelli ´99.9 per cent´ staying|
|Own goal helps Palace win in Philadelphia|
|Mourinho: Shaw deal would have ´killed´ Chelsea|
|Al Ahli Benghazi 0 ES Setif 2: Visitors on verge of semi-final spot|
|Julio Cesar returns to QPR|
|Rooney wants to lead United|
|Lallana to miss up to six weeks with knee injury|
|Isgrove maintains Koeman´s perfect start|
|Lens announce Ligue 1 appeal success|
|Pekerman talks due in August|
|PSG sanction ´harsh´, claims FFF chief|
|Garcia: Strootman going nowhere|
|Van Aanholt departs Chelsea for Sunderland|
|Benfica sign Manchester United flop Bebe|
|Campbell makes Palace move|
|Reed signs new deal at Southampton|
|Juve stunned in Allegri´s first match|
|AFA fined over Falklands banner|
|Robinho likely to move, claims agent|
|Drogba completes Chelsea return|
|Kiyotake moves to Hannover|
|Marotta: Juventus eyeing striking additions|
|Bakayoko set for Monaco switch|
|J.League Preview: Vortis out to improve dismal fortunes against Ardija|
|Juve complete Pereyra deal|
|Ranieri named Greece head coach|
|Fiorentina agree Basanta deal|
|Di Natale backs Pereyra´s Juve move|
|Iniesta: Suarez has talent to restore Barca glory|
|Cerci in charge of his future, says Cairo|
|West Ham target new striker|
|Pardew hopeful over De Jong|
|Rodgers expects new Gerrard deal|
|Jones: United embracing Van Gaal methods|
|Henry: Time had come to sell Suarez|
|Brunt eyes new West Brom deal|
|Arsenal´s World Cup winners to miss league opener|
|Modric hails Rodriguez, Kroos signings|
|Cech does not want bench role|
|Inzaghi blames fatigue for Milan loss|
|Real´s time to shine, says Ancelotti|
|Real Salt Lake 3 Montreal Impact 1: Garcia stars in Utah|
|Downing: Carroll injury a ´big blow´|
|Irvine: I have not seen Ideye play live|
|Olympiacos triumph in Toronto|
|Giggs likens Van Gaal to Ferguson|
|Copa do Brasil Review: Corinthians among trio on the verge of progression|
|Blanc: World Cup stars will move on|
|Pinto steps down as Costa Rica coach|
|Mourinho planning Drogba swoop|
|UEFA Europa League Review: Rosenborg complete comeback to see off Sligo|
|Mathieu out to enjoy Barcelona move|
|Mandzukic not Diego Costa´s replacement|
|Eliseu returns to Portugal with Benfica|
|Sanabria makes Roma switch|
|Carroll to miss start of season|
|Vidal: I´m not going to Manchester|
|Xavi staying at Barcelona|
|Hannover complete Gulselam signing|
|Astori loaned to Roma, Cagliari confirm|
|Nigeria to talk with Keshi over return|
|Gamberini makes Chievo move|
|Besic poised to complete Everton move|
|Marseille move Montpellier fixture from Stade Velodrome|
|CSL Preview: Harbin eye Luneng scalp, Guangzhou face Hena|
|Guardiola preaches patience with Lewandowski|
|Lampard joins New York City|
|Blanc coy on Di Maria speculation|
|CAF Confederation Cup Preview: ASEC coach confident, Al Ahly seek qualification|
|Chelsea loan Piazon to Frankfurt|
|Pochettino has high hopes for Lamela|
|Aguirre appointed as Japan coach|
|Swansea swoop for Montero|
|Pozuelo makes Vallecano switch|
|Fred back at Shakhtar, Ismaily to follow|
|CFF investigate Fofana accusations|
|Suarez could make sensational Clasico debut|
|Ribery in line for return, says Guardiola|
|Reus could resume training in two or three weeks - Klopp|
|Roma need another defender, says Garcia|
|Everton on verge of new signings|
|Rodrigo hails Nuno after Valencia switch|
|Delph eager for new Villa deal|
|Ljajic not seeking Roma exit|
|Talks held as players strike in Ecuador|
|Crouch excited by Bojan capture|
|Lambert expects swift recovery for Cole|
|West Ham duo fail to travel|
|United to play 3-4-3, says Van Gaal|
|Lallana, Markovic set to feature against Olympiacos|
|Real want to win every trophy, says Bale|
|San Jose Earthquakes 5 Chicago Fire 1: Hosts break winless streak|
|Chelsea have "outstanding squad" - Costa|
|United make winning start under Van Gaal|
|Rodgers plays down Borini injury concerns|
|Atletico Mineiro 4 Lanus 3 (agg 5-3): Own goals gift Brazilians the win|
|Dunga names Brazil assistants|
|Man City show class in Kansas|
|Villa too good for Dallas|
|Santos cannot meet Robinho´s demands, says vice-president|
|Mourinho happy with goalkeeper situation|
|Borini hurt as Liverpool lose to Roma|
|Palace held to draw by Crew|
|Tottenham down Toronto after Lamela brace|
|San Lorenzo 5 Bolivar 0: Hosts close in on Copa Libertadores final|
|Sunderland forward Scocco joins Newell´s|
|Rodgers: We won´t overpay in transfer market|
|Maccabi Haifa friendly abandoned after pitch invasion|
|USA dynamo Beasley joins Houston|