Ponte Preta have stunned Velez Sarsfield to advance to the Copa Sudamericana semi-finals as Libertad also progressed on Thursday.
Struggling in the Brazil Serie A, Ponte Preta claimed a 2-0 win in Buenos Aires after the first leg of their quarter-final finished 0-0.
Elias and Fernando Bob scored second-half goals for Jorginho's men, who defended resolutely after half-time at the Estadio Jose Amalfitani.
Ponte Preta will face Sao Paulo in their semi-final, while Libertad meet Lanus for a place in the decider.
Involved in a relegation battle domestically, Ponte Preta secured a surprise win at Velez Sarsfield.
The hosts had looked the more likely to score before Elias struck on 49 minutes after a fast counter-attack.
Elias exchanged passes with Rildo on the break before placing a smart finish past Sebastian Sosa in a one-on-one.
Velez Sarsfield put the pressure on and had several opportunities from corners, only for the visitors to seal victory in the second minute of additional time.
Fernando Bob was released on the break and had his initial shot saved by Sosa but was on hand to nod into an open net.
Adrianinho, an unused substituted, was red-carded for Ponte Preta after the sealer.
Libertad completed a 2-1 aggregate win over Itagui despite suffering a 1-0 loss in Colombia on Thursday.
Gustavo Bolivar scored the only goal of the game on 19 minutes but the hosts were unable to find a second on a wet Estadio Polideportivo Sur pitch.
|Coach: R. Gareca|
for H. Canteros 67'
for A. Allione 72'
for E. Rescaldani 76'
|Southampton need three January signings, says Watson|
|Liverpool can make Champions League, says fanzine editor|
|Walsh: Hull clash crucial for Leicester|
|Toure, Aubameyang and Enyeama make shortlist for African gong|
|Docherty backs Chelsea to win two-horse race|
|Liverpool could benefit from Hyypia influence - Scales|
|Saudi Arabia name Asian Cup squad|
|Forty-year-old Cahill no problem for Postecoglou|
|Wenger criticism baffles Redknapp|
|Leicester must strengthen in window - Walsh|
|United not title contenders - Docherty|
|Koeman: Southampton youngsters will get a chance|
|Dyche empathises with Liverpool striker crisis|
|Cagliari turn to Zola|
|Rooney thanks Van Gaal for Christmas break|
|Cruzeiro offer Paulinho Tottenham exit chance|
|Carlisle´s wife grateful to Burnley|
|Katebe called up to Zambia AFCON squad|
|Cape Verde name AFCON squad|
|Finke names much-changed Cameroon squad|
|Grant omits World Cup troublemakers for AFCON|
|Blackpool striker Ranger goes AWOL|
|Allardyce relishing Mourinho meeting|
|Ashley fails to increase Rangers stake|
|Crystal Palace v Southampton: Koeman calls for focus|
|Warnock targeting striker in January|
|Chelsea v West Ham: Adrian vows visitors will attack|
|Heskey signs short-term deal at Bolton|
|Everton v Stoke City: Martinez eyes strong form|
|Juninho defends David Luiz|
|Burnley v Liverpool: Dyche defends Rodgers ahead of Turf Moor test|
|Arsenal v QPR: Wenger eyes festive momentum|
|Liverpool are growing in confidence, says Rodgers|
|Redknapp: Austin future could depend on survival|
|Martinez wants Everton consistency|
|Barca want Neymar until 2020, says agent|
|Jones undeterred by pressure of Liverpool starting role|
|Allardyce ´knows how to beat managers´ - Carroll|
|Jones playing for a new contract|
|China select Evergrande spine for Asian Cup|
|A-League Preview: Koren tips City to build|
|Khedira keen to fight for Real spot|