Jermain Defoe became Tottenham's all-time leading scorer in Europe as they beat Sheriff 2-1 to reach the last 32 of the UEFA Europa League.
The striker, who equalled Martin Chivers' record in the home win over the same opponents, scored a penalty to move on to 23 goals in continental competition to earn a place in the club's record books.
Manager Andre Villas-Boas side went into the game knowing victory would see them through to the next stage as they seek their first European trophy since the UEFA Cup triumph in 1984.
Tottenham won the previous encounter between the two sides 2-0 and they had little difficulty in making it a double against the Moldovan outfit.
Erik Lamela gave the hosts the lead with a smart low finish 15 minutes into the second half, the Argentinian scoring his first goal for the club, before Defoe's historic strike from the spot.
Ismail Isa did pull one back for the visitors but it proved inconsequential as Tottenham comfortably held on.
Etienne Capoue made his first appearance since September for Tottenham after recovering from an ankle injury, while Brad Friedel came in for goalkeeper Hugo Lloris, who was rested after being knocked unconscious in the 0-0 draw with Everton last Sunday.
Tottenham looked to dominate proceedings early on, but they struggled to create chances, although Capoue should have done better when he dragged an effort wide after 10 minutes.
Sheriff looked to play on the counter-attack for the most part and they almost took a shock lead as Bulgarian striker Isa's deflected effort smacked against the right-hand post following a quick breakaway.
The hosts continued to dictate play in the closing stages of the half, Defoe failing to connect with Gylfi Sigurdsson's right-wing cross just before the break.
Sheriff defended well throughout, but they had their goalkeeper Vjekoslav Tomic to thank for keeping them on level terms as he produced a stunning save to prevent Christian Eriksen's fierce drive from finding the net.
However, Villas-Boas men did finally break the deadlock on the hour mark as Lamela turned smartly to fire home on the half-volley after Eriksen's pass had deflected into this path.
And victory looked to be all but confirmed seven minutes later, Defore etching his name into the history books with an emphatic penalty following Djbril Paye's clumsy challenge on Lamela.
Sheriff refused to lie down, though, forward Isa reacting quickest to a rebound at the near post after Friedel had saved well from Cadu.
A nervy finish was never on the cards, however, as Tottenham cruised to a deserved win.
|La Liga Review: Valencia go clear of Sevilla, crisis-stricken Elche safe|
|CAF Champions League Review: ES Tunis dumped out by Al Merreikh|
|Masterful Mourinho has Premier League and Chelsea singing his tune|
|Nantes 0 Paris Saint-Germain 2: Cavani nets again as Ibrahimovic returns|
|Napoli 3 Milan 0: Late treble saves hosts|
|Primeira Liga Review: Porto edge past strugglers Vitoria|
|Bundesliga Review: Hamburg claim last-gasp winner, Gladbach close in on Wolfsburg|
|Pochettino: Hart heroics the difference|
|Ligue 1 Review: Monaco remain on course for third, Lille cruise past Lens|
|Pellegrini silent over City future|
|Rome derby not on Lazio´s radar, says Pioli|
|Pardew laments penalty calls in Palace´s loss to champions|
|Serie A Review: Roma move back into second, Di Natale overtakes Baggio|
|Tottenham 0 Manchester City 1: Aguero heaps more misery on Spurs|
|Mourinho appears to take dig at old nemesis Guardiola|
|Mancini frustrated by resilient Chievo|
|Drogba coy over future after title triumph|
|Chelsea title win will not lead to domination - Mourinho|
|Inter 0 Chievo 0: More frustration for Mancini|
|Terry: I´ve proved Benitez wrong|
|BREAKING NEWS: Chelsea secure Premier League title|
|Chelsea 1 Crystal Palace 0: Title heads back to Stamford Bridge|
|League One Review: MK Dons promoted, as Orient, Notts County and Crawley go down|
|Dortmund striker Ramos set to miss Copa America|
|Williamson denies getting sent off on purpose|
|Eintracht Frankfurt´s Kittel suffers injury blow|
|Juventus v Real Madrid: Serie A kings set for Real test|
|United still control top-four destiny - Young|
|Record finish beyond Stoke - Hughes|
|Wellington Phoenix 0 Melbourne City 2: Surprise win sets up semi-final derby|
|Vidal already focused on Real|
|MLS Review: Revs hand Red Bulls first loss|
|AFC Champions League Preview: Wanderers facing elimination|
|Lyon stepped up despite pressure - Fournier|
|Gerrard anticipating emotional Anfield finale|
|´I´ve always wanted to score a free-kick past Neuer´ - Calhanoglu|
|Negredo: Pellegrini lost faith in me|
|Buffon had title doubts after Conte departure|
|Luis Enrique: I was worried during 8-0 win|
|Wilshere will return to his best - Wenger|
|Rodgers unconcerned by banner|
|Mourinho doesn´t want guard of honour|
|Deportivo La Coruna 1 Villarreal 1: Hosts come from behind|
|Juve canter to title success as Allegri wins over doubters|
|Primeira Liga Review: Benfica smash Gil Vicente, Sporting confirm top-three finish|
|Sassuolo 0 Palermo 0: Poor finishing results in goalless stalemate|
|Guardiola praises Bayern youngsters after Leverkusen defeat|
|Arabian Gulf League Review: Al Shabab secure continental football|
|Real focused on Juventus clash - Ancelotti|
|Bundesliga Review: Champions lose at Leverkusen, Huntelaar ends goal drought|
|CAF Champions League Review: Al Ahly fall short again, Smouha eliminate AC Leopards|
|Decisions not to blame for Bilbao stalemate - Simeone|
|Bonucci hails Scudetto with a difference|
|Ligue 1 Review: Grenier on target in Lyon win|
|Hull City v Arsenal: Bruce inspired by ´remarkable´ Wenger|
|Pulis: We got the luck we needed at Old Trafford|
|Cordoba thrashing a boost ahead of Bayern - Luis Enrique|
|Sevilla 2 Real Madrid 3: Awesome Ronaldo nets hat-trick|
|Allegri reflects on turbulent journey to glory with Juve|
|Klopp: Dortmund suffered from fatigue at Hoffenheim|
|We knew West Brom would park the bus - Van Gaal|
|Ramsey knows QPR on the brink|
|Dyche ´amazed´ by Duff red in Burnley loss|
|Manchester United 0 West Brom 1: Van Persie misses penalty as Van Gaal loses again|
|Bayer Leverkusen 2 Bayern Munich 0: Distracted champions defeated|
|Koeman frustrated by Southampton performance|
|Rodgers hails ´unique´ Gerrard after Kop winner|
|Everton suffered from United win - Martinez|
|Sunderland safety in own hands - Advocaat|
|Atletico Madrid 0 Athletic Bilbao 0: Simeone´s men rue disallowed goals|
|Oliveira ankle injury to be assessed - Monk|
|Sampdoria 0 Juventus 1: Vidal steers Juve to fourth consecutive title|
|Delph the best midfielder in England - Sherwood|
|Duff red was harsh, says West Ham boss Allardyce|
|Stoke allowed game to ´drift away´ - Hughes|
|Monk delighted with second-half display|
|Scottish Premiership Review: Muirhead winner sees Celtic crowned champions|
|Gerrard: I changed my mind on penalty|
|League Two Review: Burton secure title, Bury sneak into third|
|Pearson: We´re not safe yet|
|Liverpool 2 QPR 1: Gerrard from agony to ecstasy to leave Rangers on the brink|
|Swansea City 2 Stoke City 0: Montero nets first goal|
|Cordoba 0 Barcelona 8: Suarez nets hat-trick as hosts are relegated|
|Williamson got sent off on purpose - Carver|
|Aston Villa 3 Everton 2: Benteke double moves Villa closer to safety|
|Sunderland 2 Southampton 1: Gomez on the spot to boost survival hopes|
|West Ham 1 Burnley 0: Duff sees red as visitors pay the penalty|
|Hoffenheim 1 Borussia Dortmund 1: Honours even for Euro hopefuls|
|Leicester City 3 Newcastle United 0: Ulloa brace sinks dismal visitors|
|Championship Review: Bournemouth snatch title, Brentford and Ipswich heading for the play-offs, Blac|
|Blackpool fans lead to final Championship game being abandoned|
|Bielsa urges Marseille fight|
|Top-four was United´s primary objective - Herrera|
|Rio Ferdinand´s wife dies following cancer battle|
|Mourinho to move on quickly from title success|
|MLS Review: Dallas dismantle Dynamo, Earthquakes held by RSL|
|Liverpool open contract talks with Jones|
|Rodgers: Sterling going nowhere|
|Burnley want Dyche stay - Mee|
|Pochettino: I have final say on transfers|
|Vitoria Guimaraes 2 Estoril 0: Valente double secures routine win|
|Gaya close to agreeing new deal|
|Van Gaal expects Di Maria to stay at Old Trafford|