Jermain Defoe became Tottenham's all-time leading scorer in Europe as they beat Sheriff 2-1 to reach the last 32 of the UEFA Europa League.
The striker, who equalled Martin Chivers' record in the home win over the same opponents, scored a penalty to move on to 23 goals in continental competition to earn a place in the club's record books.
Manager Andre Villas-Boas side went into the game knowing victory would see them through to the next stage as they seek their first European trophy since the UEFA Cup triumph in 1984.
Tottenham won the previous encounter between the two sides 2-0 and they had little difficulty in making it a double against the Moldovan outfit.
Erik Lamela gave the hosts the lead with a smart low finish 15 minutes into the second half, the Argentinian scoring his first goal for the club, before Defoe's historic strike from the spot.
Ismail Isa did pull one back for the visitors but it proved inconsequential as Tottenham comfortably held on.
Etienne Capoue made his first appearance since September for Tottenham after recovering from an ankle injury, while Brad Friedel came in for goalkeeper Hugo Lloris, who was rested after being knocked unconscious in the 0-0 draw with Everton last Sunday.
Tottenham looked to dominate proceedings early on, but they struggled to create chances, although Capoue should have done better when he dragged an effort wide after 10 minutes.
Sheriff looked to play on the counter-attack for the most part and they almost took a shock lead as Bulgarian striker Isa's deflected effort smacked against the right-hand post following a quick breakaway.
The hosts continued to dictate play in the closing stages of the half, Defoe failing to connect with Gylfi Sigurdsson's right-wing cross just before the break.
Sheriff defended well throughout, but they had their goalkeeper Vjekoslav Tomic to thank for keeping them on level terms as he produced a stunning save to prevent Christian Eriksen's fierce drive from finding the net.
However, Villas-Boas men did finally break the deadlock on the hour mark as Lamela turned smartly to fire home on the half-volley after Eriksen's pass had deflected into this path.
And victory looked to be all but confirmed seven minutes later, Defore etching his name into the history books with an emphatic penalty following Djbril Paye's clumsy challenge on Lamela.
Sheriff refused to lie down, though, forward Isa reacting quickest to a rebound at the near post after Friedel had saved well from Cadu.
A nervy finish was never on the cards, however, as Tottenham cruised to a deserved win.
|Pogba lauds legendary Rooney after England retirement|
|That´s what he´s capable of – Zidane praises Ronaldo after Fiorentina stunner|
|PSG asked for Nice midfielder Seri to f*** Barca – agent|
|I think WTF? It´s your job – Klopp tells players to deliver|
|Neymar on same level as Messi and Ronaldo – Dupraz|
|Surely there´s better? – Riise questions Lovren|
|Real Madrid 2 Fiorentina 1: Banned Ronaldo nets stunner in Trofeo Santiago Bernabeu|
|Gay players in Premier League would get respect - Pogba|
|Nagelsmann slams Hoffenheim´s Anfield collapse|
|Klopp delights in Liverpool´s perfect storm|
|Champions League Review: Can bags brace as Liverpool qualify|
|Champions League is where Liverpool belong - Henderson|
|Wolves, Forest provide EFL Cup shocks as Burnley claim derby bragging rights|
|Liverpool 4 Hoffenheim 2 (6-3 agg): Can at the double in Reds´ Champions League romp|
|De Boer unsure of Zaha return date|
|Messi and Pogba launch UEFA initiative|
|Koeman respects Rooney´s England retirement|
|Carragher endorses Rooney´s England retirement|
|Sanchez: Spurs move is huge step forward|
|Hometown hero Rooney right to call time on England days|
|Evans would shine for Man City, says Northern Ireland coach O´Neill|
|FIFA takes control of Cameroon´s FA|
|Clucas completes Swansea move|
|Talent means nothing to me – Mertesacker outlines academy ethos|
|Emery embracing Neymar whirlwind as PSG aim to conquer the world|
|No words needed - Juventus midfielder Marchisio rejects transfer speculation|
|Favre critical of Balotelli performance after jewellery shenanigans|
|Atletico star Griezmann lands two-game ban for ref outburst|
|A magnificent international career - Lineker and Owen lead Rooney tributes|
|West Brom tie Dawson to new contract|
|Record at 17 to striking down Scotland – Rooney´s top five England performances|
|Huddersfield snap up Sabiri|
|Gazzaniga joins Tottenham on five-year deal|
|England still need him - Eriksson urges Rooney retirement rethink|
|53 goals, but just one at the World Cup - Wayne Rooney´s England career in Opta stats|
|Kawasaki Frontale 3 Urawa Reds 1: Kobayashi double puts hosts in control|
|Wayne Rooney retires from England international duty|
|FIFA investigating Neymar complaint over unpaid Barcelona loyalty bonus|
|Liverpool great Souness ´would snap Barcelona´s hand off´ for massive Coutinho fee|
|Walker-Peters signs new Tottenham contract after impressive debut|
|Sarri eyes Manchester United after Napoli reach Champions League groups|
|Ronaldo to play 90 minutes in Santiago Bernabeu Trophy clash|
|Seri denies Barcelona move has been agreed|
|Barcelona confirm hacking after Di Maria ´announcement´|
|Ancelotti: Bayern academy a good answer to Neymar move|
|Jedinak out of Socceroos´ crucial World Cup qualifiers|
|Rooney ready for England recall, says Jagielka|
|Barcelona a dream for everyone – Insigne|
|Champions League return a statement for Liverpool - Klopp|
|Watford early EFL Cup casualties as Bristol City take the sting out of 10-man Hornets|
|´Surprised´ PSG deny wrongdoing as Barcelona take action against Neymar|
|Champions League Review: Callejon and Insigne secure Napoli´s place at the expense of Nice|
|Neymar back in Barcelona and trolling Pique, with Messi´s help|
|FIFA condemns Fancy Bears´ leak over TUEs at 2010 World Cup|
|Southampton strengthen defence with £15m Hoedt from Lazio|
|Klopp and Coutinho´s relationship ´100 per cent´ okay|
|They will never overthrow me - Ronaldo responds to ban appeal rejection|
|AFC Champions League Review: Hulk stars in Guangzhou thrashing, Persepolis fight back against Al-Ahl|
|Mixed emotions for Rodgers and Brown as Celtic advance after ´game of basketball´|
|Ronaldo´s five-match ban upheld as latest appeal fails|
|Matuidi dreaming of Champions League glory at Juventus|
|Astana 4 Celtic 3 (4-8 agg): Rodgers´ men weather second-half storm to reach Champions League group|
|It´s a maybe - Bilic waiting on Carvalho deal|
|AC Milan apologise to Fiorentina over Mirabelli´s Kalinic joke|
|Cancelo joins Inter on loan from Valencia|
|Rojo returns to Manchester United training after four-month lay-off|
|Barcelona take legal action against Neymar for alleged breach of contract|
|Weigl back in Dortmund training as recovery from broken ankle continues|
|Fancy Bears group names players granted TUEs for World Cup 2010|
|Thiago and Martinez return to Bayern Munich training|
|Rooney´s England career is over - Hurst|
|Icardi: Argentina have the best attack in the world|
|Monaco ultras fire warning to Mbappe amid talk of PSG move|
|Mane more important to Liverpool than Barcelona target Coutinho, claims Carragher|
|Arsenal midfielder Wilshere challenges reporter after red card|
|Marseille president admits interest in Moussa Dembele|
|Kalinic capture continues AC Milan overhaul|
|Hoffenheim play better football than Liverpool – Demirbay|
|Rooney trolls ´familiar faces´ after scoring landmark goal against Manchester City|
|Messi is unsure about Barcelona future, claims Benedito|
|Giggs expects Manchester United to be hard to stop under Mourinho|
|Courtois takes swipe at Tottenham fans after Chelsea win at Wembley|
|Referee abandons match in China to catch flight|
|Fassone: No more signings planned for Milan|
|Messi´s buyout clause? Someone could pay it – Guardiola|
|Koeman lauds ´clever´ Rooney after 200th Premier League goal|
|Burnley boss Dyche tells Wood to be like Neymar|
|Mbappe to PSG will ruin Ligue 1, warns Aulas|
|Rooney revels in 200th Premier League goal as Everton hold City|
|West Brom´s Robson-Kanu loses red card appeal|
|Costa would fit in at Marseille – Eyraud|
|One of the proudest days of my life - Pep Guardiola delighted with City effort in Everton draw|