Southampton host Hull City on Saturday knowing victory would lift them back into the top four of the Premier League.
If other results go their way, Mauricio Pochettino's charges could even find themselves second - a scenario that illustrates the club's remarkable start to the 2013-14 campaign.
With just one defeat to their name this season - a record shared only by Everton and table-topping Arsenal - Southampton have established themselves as contenders for a European berth.
The south coast club had to settle for a point last time out, Jay Rodriguez's goal earning a 1-1 draw at the Britannia Stadium after Stoke City goalkeeper Asmir Begovic had sensationally opened the scoring from almost 100 yards 13 seconds into the game.
Rodriguez has since gained a first call-up to the England squad and will link up with Southampton team-mates Adam Lallana and Rickie Lambert for friendlies against Chile and Germany.
Hull's efforts this season should also not be overlooked.
Steve Bruce's men are currently the highest-placed of the promoted sides, with a 1-0 victory over nine-man Sunderland last weekend lifting them to 10th.
Fixtures between these sides have not been short of goals in recent years, the last five meetings producing a total of 20.
Southampton have had the better of the tie historically and won both encounters when the sides last shared a division - the Championship - back in 2011-12.
Hull boss Bruce is full of praise for this season's surprise package in the Premier League.
"I have to say, Southampton have been a breath of fresh air when you look at the young players they've got," he said.
"Only a few years ago the club was in administration, but fair play to them all - they've done a wonderful job.
"To get 19 points from 10 games is a wonderful achievement and it's as hard a game as we'll have. This will be another big, big test for us."
The hosts could welcome back record signing Pablo Daniel Osvaldo, who has been absent for three matches with a nerve problem, but Guly Do Prado (knee) remains sidelined.
Hull striker Sone Aluko was ruled out for eight to 10 weeks on Thursday after suffering an Achilles tear in the warm-up ahead of the clash with Sunderland.
The 24-year-old missed the second half of last season with a similar injury and a scan has indicated he is set for another lengthy spell on the sidelines.
James Chester (hamstring) and Allan McGregor (thigh) are also set to miss out for Hull.
In other injury news, referee Howard Webb has had to pull out of the tie and will be replaced by Phil Dowd.
|4||M. Schneiderlin||16' 79'|
|Coach: M. Pochettino|
for V. Wanyama 63'
for R. Lambert 76'
for A. Lallana 84'
|MLS Review: Wright-Phillips double inspires Red Bulls to New York derby rout|
|James seeks more game time at Madrid|
|Rooney: I want to be a manager|
|Mignolet welcomes Karius challenge in Liverpool number one battle|
|Batshuayi buoyed by winning vibes at Chelsea|
|Moyes and Sunderland players diverted after plane fault|
|´Loved´ Varane targets long Madrid stay|
|Kostic set for Hamburg medical|
|Leicester crying over Kante sale - Ranieri|
|Schurrle the perfect Mkhitaryan replacement - Tuchel|
|West Ham face anxious wait on Cresswell injury|
|Mourinho will accept criticism from United legends|
|Bertolacci desperate for fresh start after underwhelming first season at Milan|
|Hoops hand Toure one-year deal|
|Origi ready to fight for Liverpool spot|
|Emery wants PSG stay for ´fantastic´ Matuidi|
|No Barcelona offer for Vietto - Cerezo|
|Burnley apologise for racist abuse from supporter|
|Guardiola will not rush Kompany comeback|
|Of course I´ll shake Guardiola´s hand, snaps riled Mourinho|
|Watzke: No more signings for Dortmund|
|Roma expect Manolas to snub Premier League move|
|Adriano set to leave Barcelona for Besiktas|
|Manchester United in worst possible situation - Mourinho|
|Sporting would have to sell stadium to afford Van Persie - Jesus|
|Jonas´ agent confirms Barcelona approach|
|No problem with Mourinho, insists Guardiola ahead of derby in China|
|Toronto´s hat-trick hero Giovinco: I´m back|
|Drogba revels in ´special night´, dedicates hat-trick to family|
|MLS Review: Hat-tricks for Drogba and Giovinco as stars shine|
|Whelan backs Liverpool for top-four finish|
|Pellegrini still waiting for right offer|
|Ronaldo deserves to win Ballon d´Or - Vazquez|
|Phelan wants Hull job|
|Alaba saddened by Gotze exit|
|Morgan: Vardy right to re-sign|
|Maradona ´hurting´ as Higuain closes on Juventus move|
|Moyes watches Sunderland win, Ibe opens account in six-goal Bournemouth thriller|
|Messi cuts short holiday for Barcelona training camp|
|Ranieri still confident of keeping Mahrez|
|Toure to complete Celtic move on Sunday, says Rodgers|
|Vietto sends Simeone a reminder amid Barcelona links|
|Celtic 1 Leicester City 1 (5-6 on penalties): Mahrez magic the highlight as Ranieri´s side triumph i|
|Ribery, Alaba on target in Bayern win|
|Neymar hails Micale ahead of Olympic tilt|
|Ronaldo wants Real Madrid renewal|
|Ochoa joins Granada from Malaga|
|Heidel quashes Meyer to Liverpool as ´nonsense´|
|Scholes challenges Allardyce to change England mentality|
|Tenerife star Crosas investigated for killing endangered shark|
|De Gea: Manchester United can win title under Mourinho|
|Marseille replace Batshuayi with brother Leya Iseka|
|Cristiano Ronaldo: Best season of my career|
|Scholes: Pogba is not worth £100million|
|Gotze has not forgotten how to play football - Riedle|
|Delph learning more than ever under Guardiola|
|Jovetic ´not worried´ about Juventus|
|Allardyce wants Euro 2016 woes to fire his England|
|Giggs not in a rush to take manager´s job|
|Lopetegui: If not for Spain I would be Wolves boss|
|Shaw one of best left-backs in world - Herrera|
|Injured Sanchez to miss Arsenal tour|
|Melbourne Victory 1 Juventus 1 (Melbourne win 4-3 on pens): Thomas inspires Victory as Juve pay pena|
|Janssen: Ajax and PSV were never going to pay as much as Tottenham|
|Bayern to make Munich shooting tributes|
|Wenger wishes luck to old foe Allardyce|
|United defender Varela joins Frankfurt on loan|
|Sunderland appoint Moyes as Allardyce replacement|
|Javi Martinez devastated by Munich shootings|
|Rooney: I´m desperate to play for Mourinho, just like under Ferguson|
|Godin: Champions League the dream, but LaLiga the focus|
|Klopp hails Wijnaldum´s ´football smartness´|
|Klavan ready to fight for starting spot after completing ´dream´ Liverpool move|
|Real Salt Lake 1 San Jose Earthquakes 1: Mulholland salvages point|
|Madeira airport to be named after Cristiano Ronaldo|
|Villar, Ceferin and Van Praag announce UEFA presidential bid|
|Witsel has offers from England and Italy|
|Tuchel will bring out Gotze´s best - Watzke|
|Swansea confirm interest in Liverpool´s Allen|
|Arsenal´s Coquelin: LeBron v Curry is like Messi v Ronaldo|
|Rooney backs Allardyce appointment|
|Bayern and Ancelotti respond to Munich attacks|
|West Brom friendly cancelled over violence concerns|