Chelsea boss Jose Mourinho will seek an immediate response from his side when Schalke visit Stamford Bridge on Wednesday.
The UEFA Champions League Group E clash gives Chelsea – the 2011-12 champions – a chance to bounce back from a disappointing 2-0 defeat at Newcastle United on Saturday.
Mourinho was furious with the effort from his players after the Premier League match, branding their performance 'too soft' as late goals from Yoan Gouffran and Loic Remy saw Newcastle triumph.
The Portuguese has promised to make changes for the visit of Schalke as Chelsea go in search of their 100th win in UEFA competition.
"I will make changes. Not 11 changes because that would be too much, but changes for sure," Mourinho told Chelsea's official website.
"I don't know my best team because we have this kind of performance (against Newcastle)."
Chelsea top Group E with six points from three matches, having bounced back well from a shock 2-1 home defeat to FC Basel in September.
That result represented Chelsea's first loss in 30 home group-stage fixtures, but the club have since recorded two comfortable victories on the road, including a 3-0 win at Schalke last month.
Fernando Torres scored twice in Gelsenkirchen before Eden Hazard added polish to the scoreline with a late goal.
Marco van Ginkel (knee) is the only injury absentee for Chelsea, who sit second in the Premier League - five points behind table-toppers Arsenal.
Schalke enter the match on the back of a 2-0 win at Hertha Berlin on Saturday, a result that lifted them to sixth in the Bundesliga table.
Adam Szalai and young star Julian Draxler scored the goals for Schalke, who are now unbeaten in their last seven away matches, with six of those finishing in wins.
Schalke enjoyed success on their previous visit to the English capital, defeating Arsenal 2-0 in October last year.
They sit second in Group E, behind Chelsea on goal difference alone, and will be eager to atone for events in the reverse fixture, which saw the club suffer their worst home loss in the Champions League.
Schalke fans are excited about the development of Max Meyer, who became the youngest player in Bundesliga history to score in three successive games last month aged 18 years and 38 days.
Klaas-Jan Huntelaar will be missing, however, after suffering a recurrence of his knee injury in training last month.
The Netherlands forward scored four goals in last season's Champions League, but will not play again this year.
Jefferson Farfan (groin), Marco Hoger (knee) and Chinedu Obasi (tibia) will also miss the trip to Chelsea, while Greek defender Kyriakos Papadopoulos (knee) is a doubt.
Papadopoulos played 90 minutes for Schalke's reserves on Saturday but the 21-year-old has not played a first-team game this season.
|12||J. Obi Mikel|
|29||S. Eto'o||31' 54'|
|Coach: José Mourinho|
for S. Eto'o 77'
for A. Schürrle 78'
for Oscar 81'
|UEFA Europa League Preview: Brondby and Slovan to protect handsome leads|
|Bentaleb pens new long-term deal at Tottenham|
|Barca agree Turan deal|
|FIFA bans Mayne-Nicholls|
|United States v Honduras: Klinsmann demands improvement ahead of Gold Cup opener|
|CONCACAF institutes extensive reforms in wake of FIFA corruption scandal|
|Mauri completes Milan move|
|City sign Turkey striker|
|Women´s World Cup final draws huge US TV ratings|
|My first Chelsea team better than current crop - Drogba|
|Bertrand set for lay-off after knee surgery|
|New five-year Juve deal for Marchisio|
|Allegri extends Juve contract|
|Koeman reiterates Alderweireld interest|
|Valencia bag Bakkali|
|New York City FC complete Pirlo capture|
|Panama v Haiti: Collat ready to challenge the best of CONCACAF|
|UEFA Champions League Preview: Harrison eyes TNS progression|
|FIFA sanctions Yemen for fielding ineligible player|
|Toulouse rubbish Ben Yedder exit reports|
|Mourinho ´knows what he´s doing´ with Falcao signing|
|Watford shell out club-record fee for Capoue|
|Braafheid signs Lazio extension|
|Nani finalises Fenerbahce move|
|Liverpool confirm O´Driscoll appointment|
|Liverpool have to start better - Lucas|
|USA simply too good - Sasaki|
|Portland Timbers 1 San Jose Earthquakes 0: Jewsbury wins it in stoppage time|
|No move yet for Van Persie|
|Lloyd wins Golden Ball, Silver Boot awards|
|Mascherano: I never grabbed Banega|
|Dunga requested Brazil not appeal Neymar´s suspension|
|United States 5 Japan 2: Lloyd stars with hat-trick|
|Fiorentina deny Inter criticism|
|Nani relishing Fenerbahce opportunity|
|Newcastle hold talks over Northampton youngster|
|Cuadrado´s agent plays down Chelsea exit rumours|
|Liverpool´s Alberto set for Deportivo loan|
|Leverkusen suffer surprise defeat, Stuttgart hit six|
|Inter ´dismayed´ at Fiorentina vice-president´s Salah Twitter outburst|
|Blaszczykowski ruled out of Dortmund´s Asia tour|
|Gerrard gets the beers in for LA Galaxy fans|
|De Gea coy over Real links|
|Former Brazil star Carlos handed Delhi reins|
|Ciftci will not push through Celtic switch – agent|
|In-demand Mitrovic considering Roma offer|
|Lehmann calls on Cech to ´get over´ Chelsea|
|Marlos double sinks Monaco|
|Mauritius 0 South Africa 2 (agg 0-5): Bafana set up Angola qualifier|
|Keane relishing Gerrard arrival|
|Palace confirm Cabaye interest|
|Hamburg bring in Spahic after head-butt ban|
|Blatter hits out at France and Germany over World Cup votes|
|Sanchez: World Cup exit spurred Chile to Copa glory|
|Jojic makes Cologne switch, Santana move falls through|
|Carrillo keen to get going at Monaco|
|Micronesia thrashed 38-0 as Fiji triumph in Olympic qualifier|
|Schalke stunned by ´machine´ Caicara|
|MLS Review: Keane shines at Gerrard´s Galaxy unveiling|
|Counter-attacking the key for Japan|
|Jimenez happy at Atletico|
|Gerrard predicts ´successful future´ with Galaxy|
|Iniesta can´t see Real selling Ramos|
|Keshi sacked as Nigeria coach|
|Three finals, three defeats for Messi, Mascherano|
|Nani close to Fenerbahce move|
|Sampaoli revels in ´unbelievable joy´|
|Bravo: Copa victory a dream|
|Martino: Argentina should have won|
|Chile 0 Argentina 0 (4-1 on penalties): Hosts end trophy drought|
|Germany 0 England 1 (after extra time): England make World Cup history|