Chris Coleman should not have to contend with too many injuries for the visit of Croatia, but two key men will definitely miss out.
A red card against Scotland means Aaron Ramsey will be unavailable, while Joe Allen (shoulder) is expected to miss the remainder of the season.
However, Coleman does have some good news as Gareth Bale and David Vaughan are both available.
Igor Stimac will likely make changes to the side that beat Serbia, with veterans Ivica Olic and Josip Simunic both appearing against Sinisa Mihajlovic's side, while the latter is also carrying a knock.
Defender Simunic has been given the all-clear to play, but Stimac may not risk the 35-year-old and instead pick Domagoj Vida, while Olic's replacement will most likely be Nikica Jelavic.
Elsewhere, Niko Kranjcar (knee) is expected to miss out meaning that Josip Radosevic could take his place, or Mateo Kovacic may play in a slightly different role.
If Wales pick up a win on Tuesday, they will be four points behind Croatia with four matches to play.
After the win over Scotland, a victory against the Croatians would see Wales complete back-to-back competitive wins for the first time since Gary Speed's final two matches in charge.
The last time the two sides met, Igor Stimac's side came out on top with a 2-0 win.
Croatia dominated proceedings when they faced Wales in October, maintaining 76 per cent of possession.
Tuesday's match will be only the second time these sides have played each other in competitive competition.
Josip Simunic, Stipe Pletikosa and Darijo Srna could all win their 102nd caps against Wales.
Of the current squad, only Eduardo da Silva with 26 goals has scored more times for Croatia than right-back Srna (pictured), who has 20. The Shakhtar Donetsk man is 11/2 with BetVictor to score at any time in this match.
Sixty per cent of Wales' goals in this qualification campaign have come in the final 15 minutes of matches. Croatia, however, have not scored at all in that section of matches.
|Coach: C. Coleman|
for H. Robson-Kanu 64'
for J. Williams 83'
|Pastore: I´m like God in Paris|
|Injured Lanzini out of Olympics|
|Allegri unperturbed by Higuain fee|
|Menezes replaces Bento at Cruzeiro|
|Sporting rejected major bids from Inter and Liverpool for Joao Mario, claims father|
|Pochettino pleased by Tottenham despite Juventus defeat|
|Eriksson: Allardyce the right man for England|
|Mourinho makes United train after stepping off plane from China|
|Hazard can still match Messi, says Pedro|
|Pjanic shows there is life at Juve, with or without Pogba|
|Juventus 2 Tottenham 1: Benatia bags win for Serie A champions|
|Dembele: I am not the Bundesliga´s next superstar|
|Lyon claim €35m Arsenal offer for Lacazette rejected|
|Donnarumma dreaming of Milan captaincy as he eyes long-term stay|
|Robson: Ibrahimovic can match Van Persie´s first year at United|
|Rooney should remain England captain - Eriksson|
|Emery wants new striker at PSG|
|Santos accept Juventus bid for Gabriel|
|Eriksson expects Sweden to try and tempt Ibrahimovic out of retirement|
|Spurs signing Janssen almost quit|
|Leicester stay best for Mahrez - Ranieri|
|Allardyce to take Mourinho cue on Rooney|
|Ings ready to outdo big-money signings|
|Henderson optimistic over Liverpool campaign|
|Allardyce hardened to the challenge of England post|
|Barcelona announce record revenues for 2015-16|
|Moyes enjoys Sunderland win as Palace beat Colchester|
|Stoke complete Allen signing|
|Roma coach Spalletti warns suitors off Manolas|
|Cresswell out for up to four months with knee injury|
|Burnley fan banned by club for racist abuse|
|Dad won´t let me play at the Olympics - Larsson Sr pulls rank|
|Kostic joins Hamburg on five-year deal|
|Tevez: I´d turn down Chelsea and Napoli to stay at Boca|
|Mayoral inspired by Benzema for Wolfsburg stint|
|Allardyce straight into competitive action with England|
|Liverpool, Sevilla fined for Europa League final incidents|
|Barcelona seal Guillemenot signing as part of new Servette deal|
|Niersbach handed one-year ban over World Cup corruption|
|Chelsea and Everton ´still interested´ as Koulibaly eyes Napoli exit|
|´Still working hard´ - Balotelli trains with Liverpool kids|
|Winter breaks, long-ball football and the World Cup: Allardyce in his own words|
|Inter warn Napoli Icardi is not for sale|
|Zanetti wants Simeone back at Inter|
|Stoke snap up Sobhi|
|PSG tougher under Emery - Lucas Moura|
|Totti not ready for retirement - Pallotta|
|Confident Allardyce reveals plan for England success|
|Pochettino to discard three Tottenham players|
|Allardyce: Rooney must wait for captaincy decision|
|Aubameyang: I will only leave Dortmund for Real Madrid|
|Allegri silences questions on Pogba|
|Bruce stands by decision to quit Hull City|
|Pochettino: Not the right time for Argentina job|
|Inter yet to approach De Boer with Mancini exit rumoured|
|Ancelotti trusts me more than Guardiola - Ribery|
|Wijnaldum rejected Everton for Klopp|
|Pre-season Manchester derby cancelled|
|Coutinho excited by ´fast´ Liverpool recruits|
|Cristiano Ronaldo and Conor McGregor step into the ring together|
|Mancini coy on reports linking Icardi to Napoli|
|Nolito reveals why he chose Man City over Barcelona|
|Inter 1 Paris Saint-Germain 3: Icardi absence in defeat fuels Napoli talk|
|MLS Review: Wright-Phillips double inspires Red Bulls to New York derby rout|
|James seeks more game time at Madrid|
|Rooney: I want to be a manager|
|Mignolet welcomes Karius challenge in Liverpool number one battle|
|Batshuayi buoyed by winning vibes at Chelsea|
|Moyes and Sunderland players diverted after plane fault|
|´Loved´ Varane targets long Madrid stay|
|Kostic set for Hamburg medical|
|Leicester crying over Kante sale - Ranieri|
|Schurrle the perfect Mkhitaryan replacement - Tuchel|
|West Ham face anxious wait on Cresswell injury|
|Mourinho will accept criticism from United legends|
|Bertolacci desperate for fresh start after underwhelming first season at Milan|
|Hoops hand Toure one-year deal|
|Origi ready to fight for Liverpool spot|
|Emery wants PSG stay for ´fantastic´ Matuidi|
|No Barcelona offer for Vietto - Cerezo|
|Burnley apologise for racist abuse from supporter|
|Guardiola will not rush Kompany comeback|
|Of course I´ll shake Guardiola´s hand, snaps riled Mourinho|
|Watzke: No more signings for Dortmund|
|Roma expect Manolas to snub Premier League move|
|Adriano set to leave Barcelona for Besiktas|
|Manchester United in worst possible situation - Mourinho|
|Sporting would have to sell stadium to afford Van Persie - Jesus|
|Jonas´ agent confirms Barcelona approach|
|No problem with Mourinho, insists Guardiola ahead of derby in China|
|Toronto´s hat-trick hero Giovinco: I´m back|
|Drogba revels in ´special night´, dedicates hat-trick to family|
|MLS Review: Hat-tricks for Drogba and Giovinco as stars shine|
|Whelan backs Liverpool for top-four finish|
|Pellegrini still waiting for right offer|
|Ronaldo deserves to win Ballon d´Or - Vazquez|
|Phelan wants Hull job|
|Alaba saddened by Gotze exit|
|Morgan: Vardy right to re-sign|
|Maradona ´hurting´ as Higuain closes on Juventus move|