Louis van Gaal will be without Newcastle United goalkeeper Tim Krul due to physical problems, while Klaas-Jan Huntelaar is being plagued by a knee injury and is unavailable, too.
Roma shot-stopper Maarten Stekelenburg could return between the sticks again after missing Oranje's previous two games, while Van Gaal is likely to opt for a four-man defence consisting of promising youngsters who ply their trade in the Eredivisie.
Skipper Wesley Sneijder makes his comeback in midfield, with Robin van Persie leading the line in what promises to be a youthful-looking team.
Meanwhile, Estonia boss Tarmo Ruutli will have to make do without the likes of Taavi Rahn and Gert Kams due to injury.
Ruutli plans to field an experienced starting XI in Amsterdam, with talismanic striker Andres Oper expected to start as Estonia's lone front-man, with Joel Lindpere offering support from midfield.
Netherlands are one of only two European teams that have yet to lose points in the qualification campaign for the 2014 World Cup, Russia being the other side.
Van Persie (pictured, right) needs only two more goals to equal the legendary Johan Cruyff's record of 33 international strikes for Holland.
Feyenoord midfielder Tonny Vilhena was crowned European champion at Under-17 level less than a year ago, and could now make his debut at senior level.
Estonia have locked horns with Holland on two occasions so far, losing both at home and away in the qualification campaign for the 2002 World Cup.
The guests' all-time leading goalscorer Oper plied his trade in the Eredivisie from 2005 until 2009 at Roda before leaving for Shanghai Shenhua, only to return to Netherlands one year later at ADO Den Haag.
Estonia are one of 21 Uefa members who have never featured at a European Championship or a World Cup.
|3||S. de Vrij|
|4||B. Martins Indi|
|6||J. de Guzmán|
|9||R. van Persie||72'|
|Coach: L. van Gaal|
for W. Sneijder 36'
for J. Lens 73'
for J. de Guzmán 86'
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