England and San Marino have met three times previously, with the Three Lions winning every meeting with an aggregate score of 18 goals to one.
San Marino have not scored a goal in competitive football since 2004.
San Marino are currently joint bottom of Fifa's international rankings, level with Bhutan and Turks and Caicos Islands.
Joe Hart is the only player to have featured in every minute of England's 2014 World Cup Qualifying campaign.
The last time England played away from Wembley they were on the receiving end of a four-goal Zlatan Ibrahimvich haul that resulted in Roy Hodgson's first defeat as Three Lions manager.
In terms of percentage of games won, Hodgson (61.5%) has edged ahead of Sir Alf Ramsay (61.1%) yet is in second-place in the all time list behind Fabio Capello (66.7%).
The estimated population of San Marino is 32,404 - enough to fill just over a third of Wembley.
Steven Gerrard (pictured right) is one strike away from joining World Cup legend Martin Peters on 20 goals for his country. He is 9/2 to score the first goal in the game with William Hill.
0 - 1
12' Alessandro Della Valle (OG)
0 - 2
0 - 3
0 - 4
0 - 5
0 - 6
54' W. Rooney
0 - 7
0 - 8
|5||Alessandro Della Valle||12'|
|Coach: G. Mazza|
for E. Cibelli 65'
for A. Selva 75'
for F. Bollini 81'
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