New York Red Bulls will look to rein in MLS Eastern Conference leaders Montreal Impact when they face Philadelpia Union on Sunday.
The clash at PPL Park is set to be one of the stand-out fixtures of the weekend, as second take on third with both bidding to close the gap on the Impact.
Mike Petke's Red Bulls play for the first time since they lost 4-2 away at New England Revolution on June 12 and, after going without a win since May 29, they will be looking to get their title tilt back on track against the Union.
New York will once again rely heavily on top scorer Thierry Henry to get them the three points, with the Frenchman two ahead of Tim Cahill in the Red Bulls' goal standings on six strikes for the season.
However, their opponents will be seething after losing 3-1 to strugglers DC United, who notched up their only win of the season last time out.
Western Conference side FC Dallas top their table by just one point and they will be looking to gain some breathing space when they host Sporting Kansas City on Saturday.
They will also be boosted as Blas Perez is expected to return following international duty with Panama, while fellow striker Kenny Cooper, who was part of Manchester United's youth set-up, is also set for a comeback after a family emergency.
Schellas Hyndman's side have won four of their last five games but need another victory to keep their distance from Real Salt Lake and Portland Timbers - who are both just one point adrift - at the top of the table.
Both Salt Lake and Portland will teams play lower-placed opponents, with the former taking on Seattle Sounders on Saturday and the latter coming up against Colorado Rapids the next day.
Salt Lake finished second in their division last year before ending the season fifth overall, and have gone unbeaten at home for six games in a row this time around, meaning they are hot favourites for a win this weekend.
Portland Timbers will also have high hopes, as Colorado have failed to win a game since May 25.
The bottom of the table clashes will see Chivas USA and DC United attempt to move up their tables, with Chivas now eight points away from San Jose Earthquakes in the Western Conference.
The fledgling team will face LA Galaxy at the StubHub centre on Sunday, and they will be hoping the Galaxy continue their recent run of poor form, whcih has seen them go four games without a win, including a 5-0 loss to New England.
DC United will want to overcome the Earthquakes at home in the early kick-off on Saturday, but last year's overall winners are not in the best form themselves, and also need to move up the table.
The fixture is another big one for the Earthquakes, with interim coach Mark Watson's wanting to follow up their win in his first game oin charge with another three points.
The final two fixtures of the weekend will see Columbus Crew travel to Chicago Fire on Saturday. Colombus won 2-1 in the reverse fixture in January.
Houston Dynamo, who are fourth in the Eastern Conference, will come up against Toronto FC at the BBVA Compass Stadium on Saturday and will be looking to bounce back after losing 2-0 to Montreal on Wednesday.
|11||S. Le Toux|
|6||C. Casey||7' 63'|
|Coach: J. Hackworth|
for D. Cruz 35'
for C. Casey 74'
for B. Carroll 90+1'
|Rooney praises England aggression|
|Southgate tips Kane for return to U21s|
|Mexico v Paraguay: Goals in order for Copa America aspirants|
|Peru v Venezuela: Sanvicente wants Venezuelan response|
|Carvalho confident of playing Juventus|
|Neymar demands protection after Medel stamp|
|MLS Review: RSL, Fire secure breakthrough wins|
|Firmino firmly on radar - Dunga|
|O´Neill delighted with second-half display|
|First-half dominance pleases Deschamps|
|Muller criticises Germany profligacy|
|Euro 2016 Qualifying Review: Portugal go top, Gibraltar make history in defeat|
|Liverpool the only English club I could play for - Suarez|
|France 2 Denmark 0: Lacazette off the mark in routine victory|
|Republic of Ireland 1 Poland 1: Long rescues vital point|
|Portugal 2 Serbia 1: Coentrao puts hosts top of Group I|
|Strachan hails ´terrific´ Gibraltar|
|Lafferty back playing with a smile on his face - O´Neill|
|Toure to reveal Ivory Coast future over coming days|
|Georgia 0 Germany 2: Reus and Muller on target for world champions|
|Northern Ireland 2 Finland 1: Lafferty inspires fourth qualifying success|
|Scotland 6 Gibraltar 1: Casciaro´s historic moment outshone by Fletcher´s hat-trick|
|France 2-0 Denmark: Lacazette and Giroud on target|
|Firmino hopeful of Copa America spot|
|Hummels considering options at Dortmund|
|Suarez goalless on Anfield return, but Balotelli nets stunner|
|Casciaro scores first competitive goal for Gibraltar|
|Fleetwood Town 1 Preston North End 1: Ball stunner claims share of derby spoils|
|Italy v England: Judge me on results, says Conte|
|Colombia v Kuwait: Falcao seeking another strong showing|
|Brazil 1 Chile 0: Firmino settles scrappy affair|
|Luxembourg v Turkey: Let´s kick on, urges Terim|
|South Africa 1 Nigeria 1: Zungu strikes late to earn draw|
|Smalling wants long-term United stay|
|South Africa 1-1 Nigeria: Last-gasp Zungu goal cancels out Musa strike|
|Italy call up Santon and Abate for England friendly|
|Switzerland v United States: Klinsmann eyes learning curve|
|Netherlands v Spain: Hiddink has players´ support, says Wijnaldum|
|A-League Review: Sydney end Wellington run, Adelaide suffer injury blows in Jets win|
|Henderson eyes long-term Liverpool future|
|I have nothing to prove - Bale|
|Brazil 1-0 Chile: Firmino gives Selecao battling victory|
|South Korea v New Zealand: All Whites looking to future|
|Japan v Uzbekistan: Hosts eye another win under Halilhodzic|
|MLS Review: Kaka nets in Orlando draw|
|Mexico 1 Ecuador 0: Hernandez, Corona help Herrera´s men to victory|
|Deschamps calls for France response|
|Dunga unfazed by pressure|
|Montenegro fan turns himself in after flare incident|
|Injured Messi not ready - Martino|
|Hodgson: Rooney not close to Charlton|
|Terim proud of Turkey|
|Hiddink happy with point|
|Euro 2016 Qualifying Review: Netherlands and Italy stage late escapes|
|Debutant Eder delighted with Azzurri bow|
|Argentina 2 El Salvador 0: Mancuello nets debut goal in straightforward win|
|Kovac not satisfied despite Croatia victory|
|Netherlands 1 Turkey 1: Huntelaar spares Hiddink from historic home loss|
|Ghana 1 Senegal 2: Konate brace downs Black Stars|
|Bulgaria 2 Italy 2: Controversial debutant Eder rescues Conte´s men|
|Morocco 0 Uruguay 1: Cavani spot-kick seals win|
|Al Sadd say talks with Xavi ongoing|
|McClean slams Sunderland´s handling of poppy controversy|
|Ghana 1-2 Senegal: Black Stars continue Afcon hangover|
|Cheltenham player diagnosed with cancer|
|Palace takeover talk premature - Parish|
|Odegaard becomes Euro qualifiers´ youngest starter|
|Job not done yet, Bale warns Wales|
|Israel 0 Wales 3: Brilliant Bale bags brace as Wales go top|
|Dunga backs Neymar to overhaul Pele´s Brazil goal record|
|League Two Review: Hartlepool climb out of drop zone, Cheltenham go bottom|
|El Salvador 0-2 Argentina: Martino's men triumph without Messi|
|League One Review: Canavan leaves it late to deny County|
|Freddy Adu signs with 11th team in as many years|
|Besiktas deny Cech, Danny rumours|
|Puerto Rico v Canada: Haber targets more momentum|
|Miranda not contemplating Atletico exit|
|Austin relaxed over England prospects|
|Manchester United should sign Ibrahimovic - Schmeichel|
|Ibe eyes Liverpool run-in|
|Bertrand called up by England as withdrawal of four players confirmed|
|A-League Review: Risdon nets stunner, Germano tames Roar|
|Panama v Costa Rica: Unbeaten run a secondary concern for Wanchope|
|Italy coach Conte shaken after death threats - FIGC chief|
|Barca fears over Alba eased|
|Schweinsteiger to start Germany qualifier|
|Akinfeev thanks fans after flare incident|
|Injuries offer Kane chance of first England start|
|Russian Football Union to protest following Montenegro abandonment|
|October comeback the target for injured Foster|
|Van der Vaart looks set to leave Hamburg|
|Bale focused on Wales - Coleman|
|Kluivert helps Curacao to victory|
|Hamstrung Alba returns to Barcelona|
|Macedonia v Australia: Confident visitors eye victory|
|Akinfeev to return to Moscow with Russia squad|
|Brnovic: Montenegro have no chance of qualifying|
|Russia had to resume after Akinfeev incident - Capello|
|Terim: Robben absence important|
|Brazil - Chile Preview: Winning is 'our only option' - Dunga|
|France - Denmark Preview: Olsen hits out at 'disrespectful' hosts|
|Morata keen to keep working|
|Canada 1 Guatemala 0: Haber heads Floro´s men to win|
|Difficult to find a place for Kane in starting XI - Hodgson|
|Difficult to find a place for Kane in starting XI - Hodgson|