Malmo and Rosenborg were among the high-profile names to progess beyond the first round of UEFA Europa League qualifying on Thursday.
Swedish giants Malmo had been held to a goalless draw away at Drogheda in the teams' first-leg encounter, but scored in the dying moments of the first and second halves to defeat their Irish opponents 2-0.
Rosenborg, meanwhile, faced Crusaders from Northern Ireland, but secured an infinitely more comfortable 9-3 aggregate victory with a 7-2 win on the night at home.
The Norwegian club had goals from six different scorers to thank for their success, with John Chibuike the only man to net more than once.
Though those two were the undoubted favourites going into their ties, Prestatyn Town were clear underdogs ahead of their second meeting with Liepajas Metalurgs of Latvia.
And the Welsh side's chances looked even slimmer as they fell 3-1 behind on aggregate following an early goal from Valerijs Afanasjevs.
However, Ross Stephens struck with 13 minutes of normal time remaining to give the visitors hope before Neil Gibson grabbed a goal in the 91st minute - and Prestatyn would go on to complete a shock 4-3 win on penalties.
Crowds in Riga and Skopje were also treated to the drama of a shootout on Thursday, as Skonto beat Tiraspol 4-2 following a 1-1 aggregate draw and Turnovo saw off Suduva 5-4 on spot-kicks after their tie ended 4-4.
Elsewhere in Europe, several teams saw their hopes dashed by the away goals rule.
Ventspils saw off Airbus UK despite the sides sharing a 0-0 draw, Mladost Podgorica's 1-0 win over Videoton helped them progress, and Vaduz, Dacia and Kukes beat Chikhura, Teuta and Flora respectively by the same means.
In other results, Irtysh, Xazar Lankaran and Pyunik secured their places in the draw for the next round with wins over Levski, Sliema and Teteks.
There were also a number of thrashings meted out in the first round, with Hungarian side Budapest Honved racking up the most impressive of those.
They beat Celik Niksic 9-0 to take a place in the second round while Gefle defeated Trans 5-1, Dinamo Minsk eased to a 5-0 win over Kruoja, and Botev Plovdiv smashed Astana 5-0.
Arguably the most intriguing contest of the round came in the form of Zilina's 3-3 draw at home against Torpedo Kutaisi.
The Slovakian hosts lost their lead twice during a thrilling fixture, but could take comfort from the fact that their place in the hat was secured by a 6-3 aggregate win in the end.
Many sides were not as fortunate, however, with Gandzasar, Bala, La Fiorita and Inter Turku going out at the hands of Aktobe, Levadia, Valletta and Vikingur.
Elsewhere, Breidablik, Milsami, Qarabag, Zrinjski, Tromso, Inter Baku, IBV and Astra clinched places in the next round, with Dudelange, Metalurg Skopje, UE Santa Coloma, Celje, Mariehamn, HB, Domzale going out as a result.
And in the day's later fixtures, Vojvodina, KR, Zalgiris and Sarajevo progressed at the expense of Hibernians, Glentoran, St Patrick's and Libertas.
|Championship Review: Coleman loses first Sunderland game, Fulham win nine-goal thriller|
|City fans get first sight of local star they crave in Phil Foden|
|Gunes wants more after historic Besiktas Champions League qualification|
|Extra rest helped Rose shine in Dortmund – Pochettino|
|Allegri plays down Dybala-Messi comparisons|
|Zidane: We knew Ronaldo, Benzema goals would come|
|It feels like we lost - Klopp frustrated at Liverpool´s second-half collapse|
|It depends on Foden - Guardiola puts ball in teenager´s court|
|Postecoglou leaves Australia post|
|Ronaldo overtakes Messi in Champions League goalscoring race|
|Manchester City 1 Feyenoord 0: Sterling strikes late as top spot is clinched|
|Sevilla 3 Liverpool 3: Klopp´s side fail to survive Spanish inquisition|
|Borussia Dortmund 1 Tottenham 2: Son grabs winner as Spurs seal top spot|
|Napoli 3 Shakhtar Donetsk 0: Insigne stunner helps keep knockout hopes alive|
|APOEL 0 Real Madrid 6: Record-breaking Ronaldo and Benzema send holders through in style|
|Monaco 1 RB Leipzig 4: Werner brace dumps Ligue 1 champions out|
|Ronaldo breaks record for Champions League goals in a calendar year|
|I wanted to cry with Buffon - Rakitic sympathy for Italy great|
|Defiant Smalling responds to ´surprise´ England omission|
|Neuer ´on schedule´ but Heynckes won´t rush Bayern star|
|Messi contract saga not swaying Barcelona boss Valverde|
|Spartak Moscow 1 Maribor 1: Stoppage-time equaliser gives Russians everything to do at Anfield|
|Besiktas 1 Porto 1: Talisca leveller sends hosts through|
|Mkhitaryan questions leave Mourinho riled|
|Jones out of Basel, Brighton games but Mourinho hopeful on Bailly|
|Conte unhappy with Chelsea´s fixture congestion|
|Pepe tells Ronaldo: Come to Besiktas!|
|Clement expects Abraham to shake off back injury for Bournemouth clash|
|Oddo replaces sacked Del Neri at Udinese|
|Bartomeu hints at January Barcelona signings|
|Emery defends ´responsible´ Neymar from lifestyle criticism|
|Del Neri sacked by Udinese|
|Everton striker Niasse facing two-match ban after FA diving charge|
|Lampard excited by English clubs in Champions League|
|Thiago and Coman back for Bayern´s trip to Anderlecht|
|Dybala hails Messi as ´our Maradona´, wants to play with Neymar|
|Sherwood talks up Spurs as potential Champions League winners|
|Borussia Dortmund on the brink as Real Madrid eye progress - Champions League in Opta numbers|
|Hughton hopeful on video assistance after Brighton denied penalty|
|Klopp staying calm over Salah form|
|Griezmann: I don´t regret staying at Atletico|
|Guardiola dismisses Champions League favourites tag|
|Brighton and Hove Albion 2 Stoke City 2: Gross, Izquierdo extend home unbeaten run|
|Rose in contention to face Dortmund as Pochettino denies ´issue´ with defender|
|Benzema knows he can give more – Zidane|
|I´ve fulfilled my dreams already – Klopp has no plans to coach Barcelona|
|Aubameyang will face Tottenham, Bosz confirms|
|Klopp expects Matip to face Chelsea, Lallana return getting ´nearer´|
|Berizzo looking to former Red Aspas to provide lessons for Sevilla|
|Mangala ready to pounce, but realistic on Man City playing time|
|Mendy injury means Aguero or Jesus for Guardiola|
|Guardiola sends ´big hug´ to ´amazing, so gentle´ Pulis|
|Tavecchio quits as head of FIGC, claims board have refused to resign|
|Benedetto facing Argentina World Cup KO with cruciate injury|
|Shape up! Heynckes reveals demand to Bayern star Vidal|
|Ramos sits out Madrid trip to APOEL|
|West Brom sack Pulis after wretched run|
|Lloris wants Spurs to forget title and focus on top four|
|Pogba no Gerrard yet, says Benitez|
|Guardiola will ´kill´ City stars if they get complacent|
|Ibrahimovic: My injury was worse than people know|
|Icardi like a ´raptor pouncing on its prey´, says Spalletti|