La Liga champions Barcelona will start the defence of their crown with a home clash against Levante on August 18.
Tito Vilanova's men dominated last season, ending the term 15 points ahead of nearest challengers Real Madrid as they clinched their 22nd domestic title.
They will start their quest for their 23rd at the Camp Nou, with new Brazilian signing Neymar poised to make his league debut against a Levante team which finished 11th last season.
Real begin life under Carlo Ancelotti against Real Betis at the Bernabeu, where Isco could make his bow for the club.
Copa del Rey winners Atletico Madrid travel to Sevilla, while Real Sociedad face Getafe at the Anoeta and two clubs with UEFA Champions League ambitions meet when Valencia welcome Malaga to the Estadio Mestalla.
Newly promoted Almeria and Villarreal face off in Andalusia, and Elche begin their first top-flight campaign for 24 years at Rayo Vallecano.
Celta Vigo, who ensured survival on the final day of last term, start at home to Espanyol, while Basque duo Osasuna and Athletic Bilbao take on Granada and Real Valladolid respectively.
The first Clasico of the season takes place on October 26/27 when Real travel to Camp Nou, with the reverse fixture coming on March 22/23.
Ancelotti's men meet city rivals Atletico for the first time on September 28/29, and will travel to Estadio Vicente Calderon for the return game on March 1/2.
Valencia take on local rivals Villarreal on October 26/27 and March 22/23, and meet fellow neighbours Levante on January 4/5 and May 10/11.
Sevilla and Betis will fight for local bragging rights on November 23/24 and April 12/13, while Bilbao face biggest rivals Real Sociedad on January 4/5 and May 10/11.
The final round of fixtures takes place on May 18. Barcelona face a tough final encounter against Atletico, and Real welcome Espanyol to the Bernabeu.
Sociedad host Villarreal, Malaga take on Levante and Valencia meet Celta Vigo in three games that could well have implications on the battle for European football, as well as the fight to beat the drop.
Elche's survival hopes could rest on their last-day trip to Sevilla, while Almeria finish at home against Bilbao.
Elsewhere, Betis travel to Osasuna, Madrid sides Vallecano and Getafe meet and Valladolid will host Granada.
|High hopes for Paraguay - Diaz|
|Gareca: More to come from Peru|
|Gerrard had European offers|
|Argentina out to spoil Chile´s party - Martino|
|Sampaoli: Chile won´t change style|
|Di Maria will come good at United - Rojo|
|Peru 2 Paraguay 0: Gareca´s men finish third at Copa|
|United States 4 Guatemala 0: Klinsmann´s men win comfortably|
|´I’d prefer no-one to know my name´ - Bassett|
|Matthews completes Sunderland move|
|Podolski set for Galatasaray medical|
|Gundogan inspires Dortmund victory|
|Inter confirm Montoya capture|
|Murillo joins Inter, as Kuzmanovic and Obi depart|
|Falcao signing not a risk, says former Chelsea star|
|Deeney agrees new Watford deal|
|Confidence and service the key to Falcao success at Chelsea|
|No bids for ´Chelsea target´ Baba, claim Augsburg|
|Derby swoop for Ince|
|Fiorentina consider legal action over Salah ´no-show´|
|Chelsea the team to beat in the Premier League, says Neville|
|Storari exits Juve for Cagliari|
|UEFA removes FFP restrictions on Man City and PSG|
|West Brom hope for new owners within the month|
|Chelsea agree loan deal for Falcao|
|Kuyt eyes trophies on Feyenoord return|
|Chile v Argentina: History beckons ahead of Copa America final|
|Wallace extends Monaco loan|
|Mihajlovic wants to instill fear factor at Milan|
|Mignolet improving at Liverpool - Grobbelaar|
|Mumbai City name Anelka player-manager|
|Olivia the parrot predicts Japan to win Women´s World Cup|
|Lusitans coach blasts Bilic´s ´lack of respect´|
|Sakho eyes more Europa League wins|
|Gareca wants Peru to keep building|
|Chile ´no chance´ if Argentina produce their best - Diaz|
|Ocampos joins Marseille permanently|
|Europa League Review: Cloud-nine Brondby ignite opening round|
|West Ham 3 Lusitans 0: Sakho nets twice at start of Europa League journey|
|Holebas makes Watford move|
|Milan secure Adriano signing|
|Peru v Paraguay: Diaz counts cost of semi-final loss|
|Bastia hit out at reports of extra debt|
|Hernandez has successful surgery|
|Odemwingie signs one-year Stoke extension|
|Uth signs for Hoffenheim|
|Henen seals Everton return|
|Cattermole pens long-term Sunderland deal|
|United States v Guatemala: Klinsmann backs Dempsey ahead of Gold Cup warm-up|
|West Ham working on Jenkinson return - Gold|
|Milan agree deal for Bacca|
|Real buy back Vazquez from Espanyol|
|Richards leaves Swansea for Fulham|
|McShane signs for Reading|
|Giggs tells youngsters to seize US chance|
|Hammond pens Leicester extension|
|Only Schweinsteiger can decide Bayern future - Guardiola|
|Cech plans to play until he´s 40|
|Montoya arrives in Milan ahead of Inter move|
|Hernandez out of Gold Cup|
|US asks Switzerland to extradite seven FIFA officials|
|MLS Preview: Sounders seek momentum switch|
|Mexico 0 Honduras 0: Hernandez injury sours friendly|
|Hernandez taken to hospital|
|Garay in doubt for Copa America final|
|Wambach: USA peaking for World Cup final|
|Bassett ´an absolute hero´ despite own goal - Sampson|
|Japan 2 England 1: Late own goal breaks English hearts|
|Salvo quits as Valencia president|
|Costa not Ribery cover - Bayern director Sammer|