Montreal Impact will look to bounce back from their surprise 4-3 defeat to Colorado Rapids when they face Toronto FC in MLS on Thursday.
It was the Eastern Conference leaders' fourth loss of the regular season and they will need to return to winning ways if they are to maintain the pace at the top of the standings, with second place New York Red Bulls just a point behind, although they have played three games more.
MLS joint top-scorer Marco Di Vaio has scored 10 goals in 15 games so far this term, but has netted only once in his last four outings, with Montreal having failed to secure back-to-back wins since May.
Red Bulls take on the Rapids, who had not won in five matches prior to their 4-3 victory against Montreal, with New York having won just one of their five trips to Dick's Sporting Goods Park since its opening in 2007.
Elsewhere in the Western Conference, leaders Real Salt Lake host Philadelphia with Jason Kreis' men looking to make it five wins on the bounce and maintain their three-point lead over third-placed FC Dallas.
Schellas Hyndman takes his Texan side to basement outfit Chivas USA on Friday who are without a win in 11 league games.
Each Conference's respective fourth-placed teams will meet on Thursday at Sporting Park as Sporting Kansas City welcome Vancouver Whitecaps while the Eastern Conference's bottom club DC United can move level with ninth-place Toronto.
United travel to CenturyLink Field desperate for three points, having won just once in seven games, but will need to improve upfront against Seattle Sounders, having scored just eight times in the campaign so far.
The final game of the round takes place at the Stubhub Center on Friday as the Western Conference's fifth-placed side LA Galaxy entertain Columbus Crew, who are on a torrid run of form, having won just once in six games.
USA youth international Jose Villarreal will be available for selection after his return from the FIFA Under-20 World Cup and is determined to force his way into the Bruce Arena's plans.
"(My mindset is to) get back in training, work hard, and if I do well during training and show well, I'll get my minutes," he told the MLS official website.
"It doesn't matter if I get five or 35 or a whole 90. I've just got to be able to have a solid performance."
|Coach: R. Nelsen|
for L. Silva 75'
for D. Russell 77'
for R. Lambe 84'
|UEFA Champions League Review: Ajax crash out after home defeat|
|Blackpool handed suspended deduction|
|Bayern Munich 3 Milan 0: Guardiola and De Jong lock horns in tunnel|
|Akpom, Ojo and Solanke on the move|
|McClaren: No Newcastle bid for Austin|
|Real Madrid 2 Tottenham 0: Bale on target against former club|
|Mangala vows to improve on debut campaign|
|Tomlin completes Bournemouth switch|
|Astra v West Ham: Page hungry for first-team action|
|Di Maria arrives in Qatar for PSG medical|
|Vitesse v Southampton: Caulker prepared to wait for his chance|
|UEFA rejects Fenerbahce´s Fred appeal|
|Watford show support for assaulted fan as police charge six|
|Ibrahimovic to miss PSG opener|
|Klopp suited to Bayern job - Watzke|
|Eredivisie season-opener postponed due to police strike|
|Dortmund v Wolfsberger: Tuchel set for home bow|
|Griezmann at the double in Atletico win|
|Japan v South Korea: Halilhodzic calls for ´pride´|
|Mourinho enjoying improved relationship with Abramovich|
|Gradel agrees Bournemouth return|
|Inter switch an ´easy decision´ for Miranda|
|Bojan eyes early comeback|
|Vitesse hopeful over Solanke loan deal|
|Pedro will decide his own future - Luis Enrique|
|Iniesta handed Barcelona armband|
|Kukesi punished after Europa League abandonment|
|Leno hints at Leverkusen exit|
|Benitez explains Ronaldo absence|
|Pochettino backs Kane to be among world´s best|
|Messi not ruled out of Mexico friendly - Martino|
|China v North Korea: Kim´s side look for another win|
|River Plate v Tigres UANL: Copa Libertadores final evenly poised|
|Real target Ceballos focused on Betis - Mel|
|Torres: I´d give my life to win La Liga with Atletico|
|Platini can lead FIFA change - Fernandez|
|Mel: Betis won´t be signing Osvaldo|
|Ferrero defends Samp boss Zenga|
|Pochettino expects Spurs improvement|
|Bale ideal for United - Robson|
|Ferdinand: Di Maria will regret United failure|
|Benitez pleased with goalkeepers as De Gea transfer saga continues|
|Guardiola tips fit Schweinsteiger to shine|
|Confident Oxlade-Chamberlain hits back at Keane|
|Ferdinand: Stones would be ´a lunatic´ to join Chelsea|
|Qarabag v Celtic: Gordon wants positivity from Scottish champions|
|Higuain rejects extension from Napoli|
|Zamora returns to Brighton|
|West Ham can cope without Valencia - Gold|
|Wickham loses on Palace debut|
|Guardiola: No problem with Matthaus and Effenberg comments|
|Cartabia excited by Deportivo loan|
|Lyon confirm Rafael deal|
|Hysaj agrees deal to follow Sarri to Napoli|
|Rafael says his goodbyes to Manchester United|
|Dos Santos ready to get going with Galaxy|
|Pochettino rejects Soldado exit talk|
|Metatarsal misery for Mulumbu|
|Benitez: Benzema and Bale going nowhere|
|Mihajlovic: Ibrahimovic would make Milan title contenders|
|Hughes not taking any risks with Bojan|
|Guardiola relishing Audi Cup test|
|Di Maria ´taking a step up´ - Silva|
|Leicester bring in defender Benalouane|
|Deulofeu doubtful for Premier League opener|
|West Ham striker Valencia out for three months|
|UEFA: Qarabag-Celtic to go ahead|
|Palace seal Wickham swoop|
|Ronaldo and Benzema to miss Audi Cup|
|Marotta: Juventus could lose Pogba|
|Kante completes Leicester switch|
|Khedira ruled out for two months|
|FA accepts Mourinho criticism of Wembley surface|
|Robben rubbishes injury talk|
|Marchisio expects Milan title challenge|
|Rafael set for Lyon move|
|Celtic ´seeking reassurances´ over Qarabag pitch|
|Wenger beating Mourinho does not affect Chelsea - Zouma|
|Rooney moved by Everton welcome|
|Mancini not worried by lack of Inter goals|
|Coloccini wants to finish career at Newcastle - McClaren|
|Ramsey: Pressure to win trophies is nothing new|
|Terry: Wembley defeat could be a ´blessing in disguise´|
|Blatter not running for IOC re-election|
|Bendtner: Wolfsburg can challenge Bayern for Bundesliga honours|
|Liverpool relishing Britannia return, says Henderson|
|Everton big enough to keep Stones - Martinez|
|MLS Review: Fire stun Dallas as goals dry up|
|New Atletico signings excite Raul Garcia|
|Cahill expects Arsenal title challenge|
|Jovetic happy with Inter debut|
|Luis Enrique: Barca defence must improve|
|Yanev calls for calm after ugly scenes in friendly|
|Coppa Italia Review: Cittadella romp to victory, Brescia rely on penalties|