Netherlands coach Louis van Gaal will have to make do without the services of players such as Michel Vorm, Nigel de Jong, Erik Pieters and Luciano Narsingh due to injury.
Additionally, experienced players like Maarten Stekelenburg, John Heitinga, Rafael van der Vaart, Wesley Sneijder and Arjen Robben were all left out for various reasons.
Van Gaal is therefore expected to field a relatively inexperienced starting XI, with Daley Blind and Ola John set to make their Oranje debuts from the off.
Cesare Prandelli was dealt a bit of a blow on Monday when Juventus forward Sebastian Giovinco was forced to pull out of the squad due to a thigh problem.
Furthermore, Giorgio Chiellini, Federico Balzaretti, Christian Maggio and Claudio Marchisio are unavailable due to injury as well.
Netherlands and Italy have met 17 times so far, with the Dutch coming out victorious on only three occasions.
Jonathan de Guzman (pictured right) can become the second Canada-born player to make his Holland debut after John van 't Schip in 1986.
Robin van Persie needs only two more goals for the 2010 World Cup finalists to equal the legendary Johan Cruyff's tally of 33.
Italy recorded a 3-1 win over Oranje the last time these teams locked horns in the Amsterdam ArenA back in 2005, but had to settle for a 3-0 loss and a scoreless draw on the two occasions after that.
Captain Gianluigi Buffon is currently 13 caps short of record-holder Fabio Cannavaro, who represented the Azzurri 136 times.
Salvatore Sirigu, Marco Verratti (both Paris Saint-Germain) and Davide Santon (Newcastle United) are the only three players in the Italy squad who ply their trade abroad.
|S. de Vrij|
|B. Martins Indi|
|R. van Persie|
|Coach: L. van Gaal|
for R. van Persie 46'
for J. Clasie 46'
for O. John 60'
for D. Janmaat 85'
for A. Candreva 46'
for A. Pirlo 46'
for D. De Rossi 61'
for M. Balotelli 61'
for S. El Shaarawy 71'
for A. Barzagli 74'
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