Forwards Jermain Defoe (ankle) and Daniel Sturridge (thigh) are out of contention for England, with Theo Walcott or Danny Welbeck likely to push for a place alongside Wayne Rooney in attack.
Michael Carrick (hip) has also been ruled out of the squad, meaning Jack Wilshere may make his long-awaited return to the starting XI after featuring as a substitute against Sweden in November.
Ashley Cole is in line to receive his 100th international cap if he is selected ahead of the in-form Leighton Baines, while Gareth Barry misses out despite his fine performances for Manchester City.
Real Madrid forward Kaka has missed the cut for Brazil, but Luis Fabiano and Ronaldinho have both been included by Luiz Felipe Scolari, as well as QPR goalkeeper Julio Cesar.
Chelsea defender David Luiz is set to miss out on the game as he is suffering from a calf strain.
England have won only three of their 23 games with Brazil, losing 11 and drawing nine.
The Three Lions' winless run against the Selecao stretches back eight games - the last win came under Bobby Robson in 1990.
England won that game 1-0 courtesy of a goal from Gary Lineker.
Despite the poor run against Scolari's side, Brazil have only won two of their past 10 games at Wembley.
England have scored in all but one of their 31 games at the new Wembley.
Of their last 18 games, Brazil have won 15 and lost just twice.
The last tie between the sides saw Brazil run out 1-0 winners in Doha in 2009.
Neymar (pictured, right) will be the visitors' main threat with eight goals in his last six international appearances.
|Coach: R. Hodgson|
for T. Cleverley 46'
for A. Cole 46'
for D. Welbeck 61'
for T. Walcott 76'
|Samaras attracting Lazio interest|
|Premier League Preview: Liverpool v Cardiff City|
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|Iniesta signs new Barca contract|
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|A-League: Central Coast 1 Wellington 0|
|Spain end top of FIFA rankings for sixth year running|
|Allardyce disappointed to draw Manchester City|
|Pascoe hails ´unbelievable´ Suarez|
|Vorm knee surgery brought forward|
|Blanc hails Cavani brace|
|Michu wants Aspas to join Swansea City|
|Hoeness plays down Bayern treble suggestions|
|Dzeko confident he can fill Aguero void|
|Moyes: No loan offers for Zaha|
|Kiessling calls for Leverkusen response|
|Matuidi: Cavani on par with Ibrahimovic|
|Yeboah set to join Borussia Monchengladbach|
|Rooney a ´chance´ to face West Ham|
|FIFA Club World Cup Preview: Bayern Munich v Raja Casablanca|
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|Coupe de La Ligue Wrap: Cavani leads PSG to dramatic win|
|Copa del Rey Wrap: Real Madrid through as Sevilla crash out|
|Tottenham job appeals to Sherwood|
|Sherwood gutted after defeat|
|Hughes: United worthy winners|
|Moyes pleased to see United weather storm|
|Allardyce hails West Ham fight|
|Coppa Italia: Juventus 3 Avellino 0|
|Manchester clubs kept apart in League Cup semi draw|
|League Cup: Tottenham 1 West Ham 2|
|League Cup: Stoke City 0 Manchester United 2|
|FIFA Club World Cup: Raja Casablanca 3 Atletico Mineiro 1|
|Sheffield Wednesday, Wigan abandoned due to heavy rain|
|United face anxious Rooney wait over injury|
|Messi making good progress|
|Ramos ban overturned|
|Osvaldo charged by FA|
|In-demand Ince offered new Blackpool deal|
|Molde confirm Solskjaer approaches|
|Kramer keen to continue home record|
|Rodgers: Henderson has potential to get even better|
|Ruiz on Anderlecht´s radar|
|Swansea, Hull fined by FA over player behaviour|
|Leeds keen on re-signing Gradel|
|Leverkusen announce Ryu deal|
|Ribery named Bundesliga Player of the Year|
|Moyes: No Zaha interest|
|Barcelona, Real Madrid in European Commission investigation|
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|Chelsea set for Guarin bid, agent claims|
|Lewandowski has Dortmund goal concerns|
|Pogba, Pirlo will not sign before Christmas, says Marotta|
|Guardiola convinced to join Bayern after ´meat´ and greet|
|Martinez: Everton seen as a ´perfect´ loan destination|
|Anderlecht ´perfect´ for Defour, says Van Holsbeeck|
|Watford appoint Sannino|
|Sakho feels ´lucky´ to play with Suarez|
|Lippi: Too many teams competing in Club World Cup|
|Moyes ´told Welbeck to learn from Rooney´|
|I would kill myself over match-fixing, says Gattuso|
|Hughes dismisses calls for Januzaj protection|
|Aguero ´could miss up to two months´|
|Guardiola lauds Ballon d´Or nominee Ribery|
|Liverpool open Suarez contract talks|
|Copa del Rey Wrap: Barcelona, Levante cruise through|
|A-League Preview: Derby date beckons for winless Heart|
|Pearson upbeat despite Leicester defeat|
|Poyet urges Sunderland to build on Chelsea win|
|Mourinho rues missed chances|
|Pellegrini proud of professional Manchester City|
|Bayern on another level, says Beckenbauer|
|League Cup: Sunderland 2 Chelsea 1 (aet)|
|League Cup: Leicester City 1 Manchester City 3|
|FIFA Club World Cup: Guangzhou Evergrande 0 Bayern Munich 3|
|Zenit and Olympiacos punished with partial stadium closures|
|Sherwood wants positive reaction|
|Ancelotti expected La Liga title fight|
|Moffat charged over betting allegations|
|Wilson appointed at Barnsley|
|Wilshere charged by FA|
|Gattuso determined to clear his name|
|Moyes slams sacking culture|
|Mackay refuses to resign despite owner criticism|
|Redknapp reluctant to take Taarabt back|
|Amat pleased with development|
|Hughes optimistic of League Cup progression|
|Perez: No bids for Di Maria|
|FIFPro demand transfer system overhaul|
|Edwards sacked by Perth Glory|
|Allardyce not fearing the sack|
|Howson commits to Norwich|
|Tevez resigned to Argentina snub|
|SFA uphold Butcher´s one-match ban|
|Zapata rules out United switch|
|European Ombudsman calls for action on Spanish tax complaint|
|Albrighton eyes new Villa deal|
|Bale to miss Copa del Rey clash with ´small injury´|
|Pardew will bide his time in January|
|Kreuzer confident of Hamburg improvement|
|Van der Sar: Moyes can turn United around|
|Maradona backs Ronaldo for Ballon d´Or|
|Tottenham warned off Klinsmann|
|Costa Rica Primera Division: Alajuelense 0 Herediano 0|
|Lyon wary of Chornomorets Odesa|
|Guardiola talks up Lippi, Evergrande|
|Chile Primera Division Wrap: Chile, Deportes Iquique reach final|
|Garcia laments defensive mistakes|
|La Liga: Real Valladolid 3 Celta Vigo 0|