Valencia began life without fired coach Miroslav Djukic by scraping into the Copa del Rey last 16 with a 1-0 victory over Gimnastic.
Having been held to a goalless draw on the road in the first leg, Valencia will have been feeling more than confident about sealing their progression on home turf against third-tier opposition.
However, that proved to be easier said than done, as the hosts - under the temporary charge of Nico Estevez - struggled to break down their visitors at a sparsely populated Mestalla.
Paco Alcacer handed the Liga side the advantage in the 37th minute, before a foul on Pablo Piatti in the area late on offered substitute Helder Postiga the opportunity to double Valencia's lead from the spot.
But it proved to be an opportunity wasted as Tomeu Nadal got down well to keep out the strike and restrict Valencia, who will now take on Atletico Madrid, to a one-goal victory.
At San Mames, Athletic Bilbao stormed to a 4-0 victory over 10-man Celta Vigo to sail into a last-16 meeting with Real Betis, prevailing 4-1 on aggregate.
Iker Muniain put the hosts in front after 21 minutes, smashing home from the edge of the penalty area after a delightful flick by Aritz Aduriz.
Markel Susaeta doubled that advantage a minute short of the break, with Hugo Mallo dismissed early in the second half, before a second Muniain strike and one for Aduriz put the result beyond all doubt.
Elsewhere, Espanyol imposed their superiority as they overcame Segunda Division Real Jaen 2-0 to seal a 4-2 aggregate victory.
Simao opened the scoring for the hosts in the 12th minute, before Sidnei's strike five minutes from time secured a showdown with second-tier Alcoron.
Real Valladolid's Javi Guerra played the part of both hero and villain as his side crashed out 3-1 to Rayo Vallecano.
Following a goalless first leg, Guerra drew first blood by sending the visitors into a 28th-minute lead at Estadio del Rayo Vallecano, before Adrian drew the hosts level four minutes later.
Guerra was shown a straight red card three minutes into the second half and Valladolid failed to recover from that setback.
Adrian put the hosts ahead in the 87th minute with his second of the match, before Alberto Bueno made absolutely certain of the win in stoppage time.
Rayo will meet Levante in the next round.
|Coach: Nico Estévez|
for É. Banega 69'
for F. Cartabia 70'
for Juan Bernat 78'
|Juanfran targets new-year push|
|Long slams Southampton critics|
|Guidetti out, Griffiths in hints Deila|
|Spurs forward Kane targets 20 goals|
|Lyon fitness key to Bordeaux thrashing - Fournier|
|Santa Fe 1 Medellin 1 (agg 3-2): Hosts win Clausura title|
|Emelec 3 Barcelona 0 (4-1 agg): Bolanos brace seals title defence|
|Pioli: Lazio did not switch off|
|No Park in South Korea´s Asian Cup squad|
|Gignac: Marseille lead ´a huge boost´|
|Simeone applauds Griezmann´s hat-trick|
|Redknapp vows to keep QPR sharpshooter Austin|
|Santiago Wanderers 1 Palestino 6 (agg 2-9): 36-year drought ends for visitors|
|Juan Aurich 2 Sporting Cristal 3 (aet, agg 4-5): Chavez hands visitors Peruvian title|
|Liga del Futbol Profesional Boliviano Review: Bolivar win title|
|Mancini plays down Lennon transfer rumours|
|Ligue 1 Review: Marseille end 2014 top of the table, Lyon leapfrog PSG|
|Kovacic has mixed emotions after Inter draw|
|Serie A Review: Lazio go third despite Inter rally, Sampdoria held|
|La Liga Review: Griezmann the man for Atleti, Villarreal gain fifth straight win|
|Primeira Liga Review: Benfica win six straight|
|Athletic Bilbao 1 Atletico Madrid 4: Griezmann hat-trick seals comeback win|
|Inter 2 Lazio 2: Hosts rally to claim draw|
|McCoist makes Rangers exit|
|Sturridge on course for January return - Rodgers|
|Liverpool getting back on track, says Rodgers|
|Wenger bemoans failure to defend set-pieces|
|Bundesliga Review: Hoffenheim enjoy big win, Freiburg falter late on|
|Zorc: Dortmund to stick with Klopp|
|Liverpool 2 Arsenal 2: Bandaged Skrtel rescues a draw|
|I have no problem with Payet, insists Bielsa|
|Eredivisie Review: Ajax leave it late, Vitesse finally win|
|Pardew rues over-zealous Newcastle approach|
|Benitez hopeful ahead of Supercoppa|
|I nearly took Johnson off - Poyet|
|Johnson revels in derby late show|
|Juventus must maintain focus, warns Allegri|
|Newcastle United 0 Sunderland 1: Johnson settles derby|
|Carlos leaves Sivasspor post|
|Dundee United 2 Celtic 1: Ciftci inspires surprise win|
|Mourinho against use of independent panels|
|Hartlepool not interested in signing Evans|
|Reed delighted with first Southampton start|
|Bremen agree Oztunali loan|
|Irvine backs Ideye to end goal drought|
|Carrick backs Falcao to kick on|
|Dortmund will come back stronger, vows Klopp|
|Bojan senior slams Barcelona|
|Eredvisie title not won yet - Depay|
|Sterling eager to catch Arsenal cold|
|Monk: Ki will be sorely missed|
|Bruce looking to recall Hull duo from loan spells|
|Allardyce: Pearson deserves time|
|Sydney 0 Wellington Phoenix 2: Burns at the double|
|Real Madrid 2 San Lorenzo 0: Spanish giants complete triumphant 2014|
|McCoist: Departures sucking life out of Rangers|
|Hargreaves urges Sterling to stay put|
|Herediano 1 Deportivo Saprissa 1 (agg 3-5): Draw hands visitors consecutive titles|
|Tribulietx basks in Auckland City´s heroics|
|San Lorenzo´s Bauza applauds Ancelotti|
|Wenger: Sanchez a Footballer of the Year candidate|
|Chelsea like United´s treble-winning team - Hargreaves|
|Ancelotti: Copa del Rey victory inspired Real´s stunning run|
|La Liga Review: Catalan clubs triumph|
|Milan on right track - Inzaghi|
|Estoril 1 Vitoria Guimaraes 0: Kleber checks visitors´ momentum|
|Eredivisie Review: PSV in Eagles demolition, AZ downed at home|
|Garcia fumes at missed handball|
|Serie A Review: 10-man Milan frustrate Roma, Cesena rescue point|
|Roma 0 Milan 0: Hosts denied despite Armero red|
|Ligue 1 Review: PSG held at home, Monaco claim fourth win in a row|
|Bundesliga Review: Bremen off bottom with Dortmund win, Augsburg beat Gladbach|
|Blanc frustrated after drab stalemate|
|League Two Review: Moore´s Hartlepool tenure begins with draw|
|Championship Review: Blackpool hit for six, Middlesbrough slip up|
|Luis Enrique enjoying Pedro´s resurgence|
|Scottish Premiership Review: Aberdeen move to second, St Mirren misery continues|
|Koeman delighted with clinical Southampton|
|Pochettino tips in-form Kane for England call-up|
|Dortmund are ´idiots´ - Klopp|
|Allardyce hails ´outstanding´ Downing|
|Young admitted fault after Agbonlahor dismissal, says Lambert|
|Pearson not concerned with speculation|
|Bruce: Hull simply not good enough|
|Everton must improve - Martinez|
|Irvine rues sloppy defending|
|Cruz Azul 1 Auckland City 1 (2-4 on pens): Plucky New Zealanders claim third|
|Austin an example for young strikers - Redknapp|
|Dyche takes pride in White Hart Lane defeat|
|Arabian Gulf League Review: Al Shabab strike late to sink Al Dhafra, top two win|
|Swansea win vindicated changes, says Monk|
|Van Gaal frustrated by dropped points at Villa|
|Paris Saint-Germain 0 Montpellier 0: Champions frustrated by Courbis´ men|
|League One Review: Wilson gains landmark win as Bristol City and Swindon falter|
|Hull City 0 Swansea City 1: Monk´s men celebrate rare away win|
|Southampton 3 Everton 0: Koeman´s side back to winning ways|
|Aston Villa 1 Manchester United 1: Visitors held despite Agbonlahor dismissal|
|QPR 3 West Brom 2: Austin treble lifts hosts out of drop zone|
|Barcelona 5 Cordoba 0: Suarez opens Liga account in emphatic win|
|Tottenham 2 Burnley 1: Lamela stunner wins it for Spurs|
|West Ham 2 Leicester City 0: Carroll, Downing seal the points|
|Werder Bremen 2 Borussia Dortmund 1: Hosts off the bottom by adding to Klopp´s woes|
|Kerala Blasters 0 Atletico de Kolkata 1: Last-gasp Rafique seals inaugural title|
|Warnock fumes over disallowed goal|
|Pellegrini hails Silva quality|
|Betis announce Mel return|
|Huntelaar signs Schalke extension|
|Juventus v Napoli: Allegri backs Tevez to make difference|
|Stoke City v Chelsea: Mourinho calls for adaptability|
|Manchester City 3 Crystal Palace 0: Silva strikes twice as champions go joint-top|
|A-League Review: City snatch Melbourne derby honours, Glory pull further clear|
|Mancini: Inter can finish third|
|Sterling revels in Golden Boy award|
|Pellegrini: You never win a title in December|
|Rodgers bemoans Sanchez snub|
|Ayew confident Marseille can beat title rivals|
|Mercier: San Lorenzo won´t roll over to Real Madrid|
|Lukaku: I´m still 21|
|Mainz bemoan ´tragic´ loss to Bayern|
|Rojo ruled out for Villa trip|
|Lopetegui thrilled with Porto response|